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SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 480470, updated on 5-Mar-2024

Summary

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Official Symbol
SMURF2provided by VGNC
Official Full Name
SMAD specific E3 ubiquitin protein ligase 2provided by VGNC
Primary source
VGNC:VGNC:111730
See related
Ensembl:ENSCAFG00845023989
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (14011102..14133799, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (13244612..13367350, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (14454025..14576817)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (12957178..13079854, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (14453063..14575662)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene DEAD-box helicase 5 Neighboring gene centrosomal protein 95 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene karyopherin subunit alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase SMURF2
XP_038341117.1
XP_038402775.1
XP_038466748.1
XP_038483711.1
XP_038531965.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    14011102..14133799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676037.1 → XP_038531965.1  E3 ubiquitin-protein ligase SMURF2

    UniProtKB/TrEMBL
    A0A8C0T8J5, A0A8I3PG60, A0A8I3PQM0, A0A8P0PMF7
    Related
    ENSCAFP00845033218.1, ENSCAFT00845042371.1
    Conserved Domains (2) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:159 → 745
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    12957178..13079854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485189.1 → XP_038341117.1  E3 ubiquitin-protein ligase SMURF2

    Conserved Domains (2) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:159 → 745
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    14453063..14575662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610820.1 → XP_038466748.1  E3 ubiquitin-protein ligase SMURF2

    Conserved Domains (2) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:159 → 745
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    14454025..14576817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546847.1 → XP_038402775.1  E3 ubiquitin-protein ligase SMURF2

    UniProtKB/TrEMBL
    A0A8C0T8J5, A0A8I3PG60, A0A8I3PQM0, A0A8P0PMF7
    Conserved Domains (2) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:159 → 745
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    13244612..13367350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627783.1 → XP_038483711.1  E3 ubiquitin-protein ligase SMURF2

    UniProtKB/TrEMBL
    A0A8C0T8J5, A0A8I3PG60, A0A8I3PQM0, A0A8P0PMF7
    Conserved Domains (2) summary
    cd08382
    Location:13 → 137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:159 → 745
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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