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NFYB nuclear transcription factor Y subunit beta [ Homo sapiens (human) ]

Gene ID: 4801, updated on 26-May-2016
Official Symbol
NFYBprovided by HGNC
Official Full Name
nuclear transcription factor Y subunit betaprovided by HGNC
Primary source
HGNC:HGNC:7805
See related
Ensembl:ENSG00000120837 HPRD:01794; MIM:189904; Vega:OTTHUMG00000170176
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAP3; CBF-A; CBF-B; NF-YB
Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (104117080..104138262, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104510858..104532040, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene host cell factor C2 Neighboring gene uncharacterized LOC105369947 Neighboring gene uncharacterized LOC105369948

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of selenium concentrations.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear transcription factor Y subunit beta
Names
CAAT box DNA-binding protein subunit B
CCAAT-binding transcription factor subunit A
Transcription factor NF-Y, B subunit
nuclear transcription factor Y subunit B
nuclear transcription factor Y, beta

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006166.3NP_006157.1  nuclear transcription factor Y subunit beta

    See identical proteins and their annotated locations for NP_006157.1

    Status: REVIEWED

    Source sequence(s)
    AA479300, AL042186, AU151875, AW576189, BC005316, BF032637, BG776259, BQ420877, CD678671
    Consensus CDS
    CCDS9098.1
    UniProtKB/Swiss-Prot
    P25208
    UniProtKB/TrEMBL
    A0A024RBG7
    Related
    ENSP00000240055, OTTHUMP00000243125, ENST00000240055, OTTHUMT00000407786
    Conserved Domains (1) summary
    pfam00808
    Location:57122
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    104117080..104138262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268908.3XP_005268965.1  

    See identical proteins and their annotated locations for XP_005268965.1

    Conserved Domains (1) summary
    pfam00808
    Location:58123
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  2. XM_005268909.3XP_005268966.1  

    See identical proteins and their annotated locations for XP_005268966.1

    Conserved Domains (1) summary
    pfam00808
    Location:58123
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  3. XM_005268910.3XP_005268967.1  

    See identical proteins and their annotated locations for XP_005268967.1

    Conserved Domains (1) summary
    pfam00808
    Location:58123
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    104476772..104497954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)