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NFYA nuclear transcription factor Y, alpha [ Homo sapiens (human) ]

Gene ID: 4800, updated on 4-May-2015
Official Symbol
NFYAprovided by HGNC
Official Full Name
nuclear transcription factor Y, alphaprovided by HGNC
Primary source
HGNC:HGNC:7804
See related
HPRD:01793; MIM:189903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAP2; CBF-A; CBF-B; NF-YA
Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Orthologs
See NFYA in MapViewer
Location:
6p21.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (41072968..41102407)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41040707..41070146)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene adenylate cyclase 10 (soluble) pseudogene 1 Neighboring gene uncharacterized LOC105375056 Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene triggering receptor expressed on myeloid cells 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear transcription factor Y, alpha (NFYA) at amino acid residues 238-239 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
transcription cofactor binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear transcription factor Y subunit alpha
Names
nuclear transcription factor Y subunit alpha
CAAT box DNA-binding protein subunit A
CAAT-box DNA binding protein subunit A
CCAAT-binding transcription factor subunit B
HAP2 CCAAT-binding protein
Transcription factor NF-Y, A subunit
nuclear transcription factor Y subunit A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002505.4NP_002496.1  nuclear transcription factor Y subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_002496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes alternate exon B, resulting in the long isoform, isoform 1.
    Source sequence(s)
    AL031778, BM561405, BQ184804, X59711
    Consensus CDS
    CCDS4849.1
    UniProtKB/Swiss-Prot
    P23511
    Conserved Domains (1) summary
    pfam02045
    Location:262318
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
  2. NM_021705.3NP_068351.1  nuclear transcription factor Y subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_068351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing alternate exon B, resulting in the short isoform, isoform 2.
    Source sequence(s)
    AL031778, BC039244, BM561405, BQ184804
    Consensus CDS
    CCDS4850.1
    UniProtKB/TrEMBL
    A0A024RD22
    UniProtKB/Swiss-Prot
    P23511
    Conserved Domains (1) summary
    pfam02045
    Location:233289
    CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    41072968..41102407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    41043210..41072650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)