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    NFRKB nuclear factor related to kappaB binding protein [ Homo sapiens ]

    Gene ID: 4798, updated on 11-May-2012
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    Summary

    Official Symbol
    NFRKBprovided by HGNC
    Official Full Name
    nuclear factor related to kappaB binding proteinprovided by HGNC
    Primary source
    HGNC:7802
    See related
    Ensembl:ENSG00000170322; HPRD:01240; MIM:164013; Vega:OTTHUMG00000165761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INO80G; DKFZp547B2013
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    Genomic context

    Location :
    11q24-q25
    Sequence :
    Chromosome: 11; NC_000011.9 (129733670..129765490, complement)
    See NFRKB in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 20 Neighboring gene transmembrane protein 45B Neighboring gene PR domain containing 10 Neighboring gene long intergenic non-protein coding RNA 167 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    3. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. Giannone RJ, et al. PLoS One, 2010 Aug 25. PMID 20811636.

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q6P4R8 P19838 NFKB1    HPRD  PubMed  
    BioGRID:110864 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:122993 ACTR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:125062 ACTR8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:120076 INO80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:123646 INO80B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:125928 INO80C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:120238 INO80D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:129701 INO80E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:118931 TFPT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:119509 UCHL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110864 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		  
    colocalizes_with Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    nuclear factor related to kappa-B-binding protein
    Names
    nuclear factor related to kappa-B-binding protein
    INO80 complex subunit G
    DNA-binding protein R kappa B
    DNA-binding protein R kappa-B
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143835.1 → NP_001137307.1  nuclear factor related to kappa-B-binding protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AL512730, BC063280, BM975529, DA324031, X80878
      Consensus CDS
      CCDS44770.1
      UniProtKB/Swiss-Prot
      Q6P4R8
      Related
      ENSP00000400476, OTTHUMP00000230901, ENST00000446488, OTTHUMT00000386063
      Conserved Domains (1) summary
      pfam14465
      Location:392 – 478
      Blast Score: 356
      NFRKB_winged; NFRKB Winged Helix-like

    2. NM_006165.3 → NP_006156.2  nuclear factor related to kappa-B-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a longer N-terminus and includes an additional internal segment, compared to isoform 1.
      Source sequence(s)
      AL512730, BC063280, BM975529, X80878
      Consensus CDS
      CCDS8483.1
      UniProtKB/Swiss-Prot
      Q6P4R8
      Related
      ENSP00000436926, OTTHUMP00000230902, ENST00000524794, OTTHUMT00000386064
      Conserved Domains (1) summary
      pfam14465
      Location:417 – 503
      Blast Score: 355
      NFRKB_winged; NFRKB Winged Helix-like

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      129733670..129765490, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      125685954..125717786, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP003327.3 (114145..142691) None
    genomic CH471065.1 EAW67752.1
      EAW67753.1
      EAW67754.1
      EAW67755.1
      EAW67756.1
      EAW67757.1
      EAW67758.1
    mRNA AL512730.1 CAC21663.1
    mRNA BC063280.1 AAH63280.1
    mRNA BM975529.1 None
    mRNA DA324031.1 None
    mRNA X80878.1 CAA56846.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4R8.2 GenPept UniProtKB/Swiss-Prot:Q6P4R8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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