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NFRKB nuclear factor related to kappaB binding protein [ Homo sapiens (human) ]

Gene ID: 4798, updated on 8-May-2016
Official Symbol
NFRKBprovided by HGNC
Official Full Name
nuclear factor related to kappaB binding proteinprovided by HGNC
Primary source
HGNC:HGNC:7802
See related
Ensembl:ENSG00000170322 HPRD:01240; MIM:164013; Vega:OTTHUMG00000165761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INO80G
Orthologs
Location:
11q24-q25
Exon count:
29
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (129863773..129895595, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129733670..129765490, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1395 Neighboring gene transmembrane protein 45B Neighboring gene PR domain 10 Neighboring gene long intergenic non-protein coding RNA 167 Neighboring gene transcription elongation factor B subunit 2 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
    DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
    Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp547B2013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear factor related to kappa-B-binding protein
Names
DNA-binding protein R kappa B
DNA-binding protein R kappa-B
INO80 complex subunit G

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143835.1NP_001137307.1  nuclear factor related to kappa-B-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001137307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AL512730, BC063280, BM975529, DA324031, X80878
    Consensus CDS
    CCDS44770.1
    UniProtKB/Swiss-Prot
    Q6P4R8
    UniProtKB/TrEMBL
    A0A024R3K9
    Related
    ENSP00000400476, OTTHUMP00000230901, ENST00000446488, OTTHUMT00000386063
    Conserved Domains (2) summary
    PHA03255
    Location:839975
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:379478
    NFRKB_winged; NFRKB Winged Helix-like
  2. NM_006165.3NP_006156.2  nuclear factor related to kappa-B-binding protein isoform 2

    See identical proteins and their annotated locations for NP_006156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a longer N-terminus and includes an additional internal segment, compared to isoform 1.
    Source sequence(s)
    AL512730, BC063280, BM975529, X80878
    Consensus CDS
    CCDS8483.1
    UniProtKB/Swiss-Prot
    Q6P4R8
    Related
    ENSP00000436926, OTTHUMP00000230902, ENST00000524794, OTTHUMT00000386064
    Conserved Domains (2) summary
    PHA03255
    Location:8641000
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:404503
    NFRKB_winged; NFRKB Winged Helix-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    129863773..129895595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271567.2XP_005271624.1  

    See identical proteins and their annotated locations for XP_005271624.1

    Conserved Domains (2) summary
    PHA03255
    Location:851987
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:391490
    NFRKB_winged; NFRKB Winged Helix-like
  2. XM_005271568.2XP_005271625.1  

    See identical proteins and their annotated locations for XP_005271625.1

    Conserved Domains (2) summary
    PHA03255
    Location:851987
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:391490
    NFRKB_winged; NFRKB Winged Helix-like
  3. XM_011542851.1XP_011541153.1  

    See identical proteins and their annotated locations for XP_011541153.1

    UniProtKB/Swiss-Prot
    Q6P4R8
    Conserved Domains (2) summary
    PHA03255
    Location:8641000
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:404503
    NFRKB_winged; NFRKB Winged Helix-like
  4. XM_011542852.1XP_011541154.1  

    See identical proteins and their annotated locations for XP_011541154.1

    UniProtKB/Swiss-Prot
    Q6P4R8
    Conserved Domains (2) summary
    PHA03255
    Location:8641000
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:404503
    NFRKB_winged; NFRKB Winged Helix-like
  5. XM_011542850.1XP_011541152.1  

    Conserved Domains (2) summary
    PHA03255
    Location:8741010
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:414513
    NFRKB_winged; NFRKB Winged Helix-like
  6. XM_011542849.1XP_011541151.1  

    Conserved Domains (2) summary
    PHA03255
    Location:9011037
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:441540
    NFRKB_winged; NFRKB Winged Helix-like
  7. XM_011542853.1XP_011541155.1  

    Conserved Domains (1) summary
    pfam14465
    Location:453552
    NFRKB_winged; NFRKB Winged Helix-like
  8. XM_011542848.1XP_011541150.1  

    Conserved Domains (2) summary
    PHA03255
    Location:9131049
    PHA03255; BDLF3; Provisional
    pfam14465
    Location:453552
    NFRKB_winged; NFRKB Winged Helix-like

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    129619262..129651095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)