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KALRN kalirin RhoGEF kinase [ Canis lupus familiaris (dog) ]

Gene ID: 478592, updated on 22-Jan-2024

Summary

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Official Symbol
KALRNprovided by VGNC
Official Full Name
kalirin RhoGEF kinaseprovided by VGNC
Primary source
VGNC:VGNC:42200
See related
Ensembl:ENSCAFG00845026150
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Genomic context

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Location:
chromosome: 33
Exon count:
37
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (27329328..27797773)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (27117706..27776818)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (27786940..28447934)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (27125464..27784937)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (27169910..27829241)

Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1 Neighboring gene drebrin-like protein Neighboring gene kalirin-like Neighboring gene uncharacterized LOC119867343 Neighboring gene uncharacterized LOC106558170 Neighboring gene uridine monophosphate synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
kalirin; LOW QUALITY PROTEIN: kalirin
XP_003434128.1
XP_013965661.1
XP_013965662.1
XP_022269736.1
XP_038301113.1
XP_038301114.1
XP_038301115.1
XP_038301116.1
XP_038301117.1
XP_038301118.1
XP_038301119.1
XP_038301120.1
XP_038318537.1
XP_038318538.1
XP_038318539.1
XP_038318540.1
XP_038318541.1
XP_038318542.1
XP_038318543.1
XP_038318544.1
XP_038318545.1
XP_038318546.1
XP_038318547.1
XP_038318548.1
XP_038318549.1
XP_038318550.1
XP_038318551.1
XP_038318552.1
XP_038318553.1
XP_038318554.1
XP_038318555.1
XP_038318556.1
XP_038318557.1
XP_038318558.1
XP_038318559.1
XP_038318560.1
XP_038318561.1
XP_038375341.1
XP_038375342.1
XP_038375343.1
XP_038375344.1
XP_038375345.1
XP_038375346.1
XP_038375347.1
XP_038375348.1
XP_038375349.1
XP_038375350.1
XP_038375351.1
XP_038375352.1
XP_038375353.1
XP_038375354.1
XP_038375355.1
XP_038375356.1
XP_038375357.1
XP_038375358.1
XP_038375359.1
XP_038375360.1
XP_038375361.1
XP_038375362.1
XP_038375363.1
XP_038375364.1
XP_038375365.1
XP_038375366.1
XP_038375367.1
XP_038375368.1
XP_038375369.1
XP_038375370.1
XP_038438988.1
XP_038503379.1
XP_038503380.1
XP_038503381.1
XP_038503382.1
XP_038503383.1
XP_038503384.1
XP_038503385.1
XP_038503386.1
XP_038503387.1
XP_038503388.1
XP_038503389.1
XP_038503390.1
XP_038503391.1
XP_038503392.1
XP_038503393.1
XP_038503394.1
XP_038503395.1
XP_038503396.1
XP_038503397.1
XP_038503398.1
XP_038503399.1
XP_038503400.1
XP_038503401.1
XP_038503402.1
XP_038503403.1
XP_038503404.1
XP_038503405.1
XP_038503406.1
XP_038503407.1
XP_535768.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051837.1 Reference ROS_Cfam_1.0

    Range
    27329328..27797773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445185.1 → XP_038301113.1  kalirin isoform X1

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  2. XM_038445187.1 → XP_038301115.1  kalirin isoform X3

    UniProtKB/TrEMBL
    A0A8I3PWP5, A0A8I3PXL3, A0A8P0NU84
    Related
    ENSCAFP00845036241.1, ENSCAFT00845046156.1
    Conserved Domains (5) summary
    smart00150
    Location:1128 → 1228
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  3. XM_038445189.1 → XP_038301117.1  kalirin isoform X5

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  4. XM_038445190.1 → XP_038301118.1  kalirin isoform X6

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Related
    ENSCAFP00845036962.1, ENSCAFT00845047098.1
    Conserved Domains (5) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  5. XM_038445186.1 → XP_038301114.1  kalirin isoform X2

    UniProtKB/TrEMBL
    A0A8C0NTD4, A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  6. XM_038445188.1 → XP_038301116.1  kalirin isoform X4

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  7. XM_038445191.1 → XP_038301119.1  kalirin isoform X7

    UniProtKB/TrEMBL
    A0A8C0QVD9
    Conserved Domains (5) summary
    smart00150
    Location:1036 → 1136
    SPEC; Spectrin repeats
    cd00160
    Location:1185 → 1355
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:792 → 1030
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1362 → 1484
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cl15787
    Location:1 → 78
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  8. XM_038445192.1 → XP_038301120.1  kalirin isoform X8

    Conserved Domains (5) summary
    smart00150
    Location:565 → 665
    SPEC; Spectrin repeats
    cd00160
    Location:714 → 884
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:321 → 559
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:891 → 1013
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cl02488
    Location:25 → 148
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049293.1 Alternate UMICH_Zoey_3.1

    Range
    27125464..27784937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519413.1 → XP_038375341.1  kalirin isoform X9

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2572 → 2663
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2693 → 2940
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2474 → 2568
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2466 → 2469
    Ig; Ig strand A [structural motif]

  2. XM_038519420.1 → XP_038375348.1  kalirin isoform X16

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2552 → 2643
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2673 → 2920
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2454 → 2548
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2446 → 2449
    Ig; Ig strand A [structural motif]

  3. XM_038519414.1 → XP_038375342.1  kalirin isoform X10

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2465 → 2468
    Ig; Ig strand A [structural motif]

  4. XM_038519422.1 → XP_038375350.1  kalirin isoform X18

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2295 → 2353
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2540 → 2631
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2077 → 2211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2661 → 2908
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1903 → 2072
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2442 → 2536
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1847
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2434 → 2437
    Ig; Ig strand A [structural motif]

  5. XM_038519415.1 → XP_038375343.1  kalirin isoform X11

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2465 → 2468
    Ig; Ig strand A [structural motif]

  6. XM_038519416.1 → XP_038375344.1  kalirin isoform X12

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2464 → 2467
    Ig; Ig strand A [structural motif]

  7. XM_038519423.1 → XP_038375351.1  kalirin isoform X19

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2294 → 2352
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2539 → 2630
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2076 → 2210
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2660 → 2907
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1902 → 2071
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2441 → 2535
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1846
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2433 → 2436
    Ig; Ig strand A [structural motif]

  8. XM_038519421.1 → XP_038375349.1  kalirin isoform X17

    Conserved Domains (14) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    cd11852
    Location:1629 → 1688
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2305 → 2363
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2550 → 2641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2087 → 2221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2671 → 2918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1913 → 2082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2452 → 2546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1686 → 1870
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2444 → 2447
    Ig; Ig strand A [structural motif]

  9. XM_038519425.1 → XP_038375353.1  kalirin isoform X21

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  10. XM_038519427.1 → XP_038375355.1  kalirin isoform X23

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  11. XM_038519428.1 → XP_038375356.1  kalirin isoform X24

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  12. XM_038519429.1 → XP_038375357.1  kalirin isoform X25

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  13. XM_038519430.1 → XP_038375358.1  kalirin isoform X1

    Conserved Domains (5) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  14. XM_038519432.1 → XP_038375360.1  kalirin isoform X3

    Conserved Domains (5) summary
    smart00150
    Location:1128 → 1228
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  15. XM_038519434.1 → XP_038375362.1  kalirin isoform X5

    Conserved Domains (5) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  16. XM_038519435.1 → XP_038375363.1  kalirin isoform X6

    Conserved Domains (5) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  17. XM_038519419.1 → XP_038375347.1  kalirin isoform X15

    Conserved Domains (14) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    cd11852
    Location:1638 → 1697
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2314 → 2372
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2559 → 2650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2096 → 2230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2680 → 2927
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1922 → 2091
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2461 → 2555
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1695 → 1879
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2453 → 2456
    Ig; Ig strand A [structural motif]

  18. XM_038519431.1 → XP_038375359.1  kalirin isoform X2

    Conserved Domains (5) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  19. XM_038519433.1 → XP_038375361.1  kalirin isoform X4

    Conserved Domains (5) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  20. XM_038519417.1 → XP_038375345.1  kalirin isoform X13

  21. XM_038519418.1 → XP_038375346.1  kalirin isoform X14

  22. XM_038519424.1 → XP_038375352.1  kalirin isoform X20

    Conserved Domains (14) summary
    smart00150
    Location:1036 → 1136
    SPEC; Spectrin repeats
    cd11852
    Location:1550 → 1609
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2226 → 2284
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:2471 → 2562
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1185 → 1355
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:792 → 1030
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1362 → 1484
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2008 → 2142
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2592 → 2839
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1834 → 2003
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2373 → 2467
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1607 → 1791
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2365 → 2368
    Ig; Ig strand A [structural motif]
    cl15787
    Location:1 → 78
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  23. XM_038519426.1 → XP_038375354.1  kalirin isoform X22

  24. XM_038519436.1 → XP_038375364.1  kalirin isoform X26

    Conserved Domains (8) summary
    cd11853
    Location:628 → 686
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:873 → 964
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:994 → 1241
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:775 → 869
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:28 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:767 → 770
    Ig; Ig strand A [structural motif]

  25. XM_038519437.1 → XP_038375365.1  kalirin isoform X27

    Conserved Domains (8) summary
    cd11853
    Location:627 → 685
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:872 → 963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:993 → 1240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:774 → 868
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:28 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:766 → 769
    Ig; Ig strand A [structural motif]

  26. XM_038519438.1 → XP_038375366.1  kalirin isoform X28

    Conserved Domains (4) summary
    cd11853
    Location:626 → 684
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:409 → 543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:235 → 404
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 192
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  27. XM_038519439.1 → XP_038375367.1  kalirin isoform X29

    Conserved Domains (4) summary
    cd11853
    Location:596 → 654
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  28. XM_038519441.1 → XP_038375369.1  kalirin isoform X31

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  29. XM_038519440.1 → XP_038375368.1  kalirin isoform X30

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  30. XM_038519442.1 → XP_038375370.1  kalirin isoform X32

    Conserved Domains (4) summary
    cd11853
    Location:594 → 652
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

    Range
    27169910..27829241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647451.1 → XP_038503379.1  kalirin isoform X33

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2572 → 2663
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2693 → 2940
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2474 → 2568
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2466 → 2469
    Ig; Ig strand A [structural motif]

  2. XM_038647458.1 → XP_038503386.1  kalirin isoform X40

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2552 → 2643
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2673 → 2920
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2454 → 2548
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2446 → 2449
    Ig; Ig strand A [structural motif]

  3. XM_038647452.1 → XP_038503380.1  kalirin isoform X34

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2465 → 2468
    Ig; Ig strand A [structural motif]

  4. XM_038647460.1 → XP_038503388.1  kalirin isoform X42

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2295 → 2353
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2540 → 2631
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2077 → 2211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2661 → 2908
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1903 → 2072
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2442 → 2536
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1847
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2434 → 2437
    Ig; Ig strand A [structural motif]

  5. XM_038647453.1 → XP_038503381.1  kalirin isoform X35

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2465 → 2468
    Ig; Ig strand A [structural motif]

  6. XM_038647454.1 → XP_038503382.1  kalirin isoform X36

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2464 → 2467
    Ig; Ig strand A [structural motif]

  7. XM_038647461.1 → XP_038503389.1  kalirin isoform X43

    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2294 → 2352
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2539 → 2630
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2076 → 2210
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2660 → 2907
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1902 → 2071
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2441 → 2535
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1846
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2433 → 2436
    Ig; Ig strand A [structural motif]

  8. XM_038647459.1 → XP_038503387.1  kalirin isoform X41

    Conserved Domains (14) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    cd11852
    Location:1629 → 1688
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2305 → 2363
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2550 → 2641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2087 → 2221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2671 → 2918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1913 → 2082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2452 → 2546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1686 → 1870
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2444 → 2447
    Ig; Ig strand A [structural motif]

  9. XM_038647462.1 → XP_038503390.1  kalirin isoform X44

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  10. XM_038647464.1 → XP_038503392.1  kalirin isoform X46

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  11. XM_038647465.1 → XP_038503393.1  kalirin isoform X47

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  12. XM_038647466.1 → XP_038503394.1  kalirin isoform X48

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  13. XM_038647467.1 → XP_038503395.1  kalirin isoform X1

    Conserved Domains (5) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  14. XM_038647469.1 → XP_038503397.1  kalirin isoform X3

    Conserved Domains (5) summary
    smart00150
    Location:1128 → 1228
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  15. XM_038647471.1 → XP_038503399.1  kalirin isoform X5

    Conserved Domains (5) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  16. XM_038647472.1 → XP_038503400.1  kalirin isoform X6

    Conserved Domains (5) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  17. XM_038647457.1 → XP_038503385.1  kalirin isoform X39

    Conserved Domains (14) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    cd11852
    Location:1638 → 1697
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2314 → 2372
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2559 → 2650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2096 → 2230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2680 → 2927
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1922 → 2091
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2461 → 2555
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1695 → 1879
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2453 → 2456
    Ig; Ig strand A [structural motif]

  18. XM_038647468.1 → XP_038503396.1  kalirin isoform X2

    Conserved Domains (5) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  19. XM_038647470.1 → XP_038503398.1  kalirin isoform X4

    Conserved Domains (5) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  20. XM_038647455.1 → XP_038503383.1  kalirin isoform X37

  21. XM_038647456.1 → XP_038503384.1  kalirin isoform X38

  22. XM_038647463.1 → XP_038503391.1  kalirin isoform X45

  23. XM_038647473.1 → XP_038503401.1  kalirin isoform X49

    Conserved Domains (8) summary
    cd11853
    Location:628 → 686
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:873 → 964
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:994 → 1241
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:775 → 869
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:28 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:767 → 770
    Ig; Ig strand A [structural motif]

  24. XM_038647474.1 → XP_038503402.1  kalirin isoform X50

    Conserved Domains (8) summary
    cd11853
    Location:627 → 685
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:872 → 963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:993 → 1240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:774 → 868
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:28 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:766 → 769
    Ig; Ig strand A [structural motif]

  25. XM_038647475.1 → XP_038503403.1  kalirin isoform X51

    Conserved Domains (4) summary
    cd11853
    Location:626 → 684
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:409 → 543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:235 → 404
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 192
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  26. XM_038647476.1 → XP_038503404.1  kalirin isoform X52

    Conserved Domains (4) summary
    cd11853
    Location:596 → 654
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  27. XM_038647478.1 → XP_038503406.1  kalirin isoform X54

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  28. XM_038647477.1 → XP_038503405.1  kalirin isoform X53

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  29. XM_038647479.1 → XP_038503407.1  kalirin isoform X55

    Conserved Domains (4) summary
    cd11853
    Location:594 → 652
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

    Range
    27786940..28447934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583060.1 → XP_038438988.1  LOW QUALITY PROTEIN: kalirin isoform X56

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2464 → 2467
    Ig; Ig strand A [structural motif]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    27117706..27776818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462609.1 → XP_038318537.1  kalirin isoform X57

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2572 → 2663
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2693 → 2940
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2474 → 2568
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2466 → 2469
    Ig; Ig strand A [structural motif]

  2. XM_038462614.1 → XP_038318542.1  kalirin isoform X64

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2552 → 2643
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2673 → 2920
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2454 → 2548
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2446 → 2449
    Ig; Ig strand A [structural motif]

  3. XM_038462610.1 → XP_038318538.1  kalirin isoform X58

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2465 → 2468
    Ig; Ig strand A [structural motif]

  4. XM_038462616.1 → XP_038318544.1  kalirin isoform X66

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2295 → 2353
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2540 → 2631
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2077 → 2211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2661 → 2908
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1903 → 2072
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2442 → 2536
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1847
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2434 → 2437
    Ig; Ig strand A [structural motif]

  5. XM_038462611.1 → XP_038318539.1  kalirin isoform X59

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2465 → 2468
    Ig; Ig strand A [structural motif]

  6. XM_038462612.1 → XP_038318540.1  kalirin isoform X60

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1891
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2464 → 2467
    Ig; Ig strand A [structural motif]

  7. XM_038462617.1 → XP_038318545.1  kalirin isoform X67

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2294 → 2352
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2539 → 2630
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2076 → 2210
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2660 → 2907
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1902 → 2071
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2441 → 2535
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1846
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2433 → 2436
    Ig; Ig strand A [structural motif]

  8. XM_038462615.1 → XP_038318543.1  kalirin isoform X65

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    cd11852
    Location:1629 → 1688
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2305 → 2363
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2550 → 2641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2087 → 2221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2671 → 2918
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1913 → 2082
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2452 → 2546
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1686 → 1870
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2444 → 2447
    Ig; Ig strand A [structural motif]

  9. XM_038462619.1 → XP_038318547.1  kalirin isoform X69

    UniProtKB/TrEMBL
    A0A8P0SZ53
    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  10. XM_038462620.1 → XP_038318548.1  kalirin isoform X71

    UniProtKB/TrEMBL
    A0A8P0SZ53
    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  11. XM_038462621.1 → XP_038318549.1  kalirin isoform X72

    UniProtKB/TrEMBL
    A0A8P0SZ53
    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  12. XM_038462622.1 → XP_038318550.1  kalirin isoform X73

    UniProtKB/TrEMBL
    A0A8P0SZ53
    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    TIGR02168
    Location:747 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  13. XM_038462623.1 → XP_038318551.1  kalirin isoform X1

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1131
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  14. XM_038462624.1 → XP_038318552.1  kalirin isoform X3

    UniProtKB/TrEMBL
    A0A8I3PWP5, A0A8I3PXL3, A0A8P0NU84
    Conserved Domains (5) summary
    smart00150
    Location:1128 → 1228
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  15. XM_038462625.1 → XP_038318553.1  kalirin isoform X5

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  16. XM_038462626.1 → XP_038318554.1  kalirin isoform X6

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:880 → 1109
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  17. XM_038462613.1 → XP_038318541.1  kalirin isoform X63

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    cd11852
    Location:1638 → 1697
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2314 → 2372
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2559 → 2650
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2096 → 2230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2680 → 2927
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1922 → 2091
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2461 → 2555
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1695 → 1879
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2453 → 2456
    Ig; Ig strand A [structural motif]

  18. XM_003434080.5 → XP_003434128.1  kalirin isoform X2

    UniProtKB/TrEMBL
    A0A8C0NTD4, A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  19. XM_022414028.2 → XP_022269736.1  kalirin isoform X4

    UniProtKB/TrEMBL
    A0A8I3PWP5
    Conserved Domains (5) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  20. XM_535768.7 → XP_535768.3  kalirin isoform X61

    UniProtKB/TrEMBL
    A0A8C0NK11, A0A8C0TNG2, A0A8P0SH79
    Conserved Domains (13) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1129
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2107 → 2241
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1933 → 2102
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1706 → 1890
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  21. XM_014110186.3 → XP_013965661.1  kalirin isoform X62

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (13) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    cd11852
    Location:1640 → 1699
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2316 → 2374
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2561 → 2652
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2463 → 2557
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2098 → 2232
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2682 → 2929
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1924 → 2093
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1697 → 1881
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  22. XM_038462618.1 → XP_038318546.1  kalirin isoform X68

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (14) summary
    smart00150
    Location:1036 → 1136
    SPEC; Spectrin repeats
    cd11852
    Location:1550 → 1609
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2226 → 2284
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:2471 → 2562
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1185 → 1355
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:792 → 1030
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1362 → 1484
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2008 → 2142
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2592 → 2839
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1834 → 2003
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2373 → 2467
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1607 → 1791
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:2365 → 2368
    Ig; Ig strand A [structural motif]
    cl15787
    Location:1 → 78
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  23. XM_014110187.3 → XP_013965662.1  kalirin isoform X70

    UniProtKB/TrEMBL
    A0A8C0NK11
    Conserved Domains (13) summary
    smart00150
    Location:565 → 665
    SPEC; Spectrin repeats
    cd11852
    Location:1079 → 1138
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:1755 → 1813
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:2000 → 2091
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:714 → 884
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:321 → 559
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:1902 → 1996
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:891 → 1013
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:1537 → 1671
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2121 → 2368
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1363 → 1532
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1136 → 1320
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:25 → 196
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  24. XM_038462627.1 → XP_038318555.1  kalirin isoform X74

    UniProtKB/TrEMBL
    A0A8C0NRT9, A0A8C0TP03, A0A8P0PQL3
    Conserved Domains (8) summary
    cd11853
    Location:628 → 686
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:873 → 964
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:994 → 1241
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:775 → 869
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:28 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:767 → 770
    Ig; Ig strand A [structural motif]

  25. XM_038462628.1 → XP_038318556.1  kalirin isoform X75

    UniProtKB/TrEMBL
    A0A8C0NRT9
    Conserved Domains (8) summary
    cd11853
    Location:627 → 685
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:872 → 963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:993 → 1240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:774 → 868
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:28 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:766 → 769
    Ig; Ig strand A [structural motif]

  26. XM_038462629.1 → XP_038318557.1  kalirin isoform X76

    Conserved Domains (4) summary
    cd11853
    Location:626 → 684
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:409 → 543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:235 → 404
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 192
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  27. XM_038462630.1 → XP_038318558.1  kalirin isoform X77

    Conserved Domains (4) summary
    cd11853
    Location:596 → 654
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  28. XM_038462632.1 → XP_038318560.1  kalirin isoform X79

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  29. XM_038462631.1 → XP_038318559.1  kalirin isoform X78

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  30. XM_038462633.1 → XP_038318561.1  kalirin isoform X80

    Conserved Domains (4) summary
    cd11853
    Location:594 → 652
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:28 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
Nucleotide Protein
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