crc cryptocephal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: crcprovided by FlyBase
Official Full Name: cryptocephalprovided by FlyBase
Primary source: FLYBASE:FBgn0000370
Locus tag: Dmel_CG8669
See related: AllianceGenome:FB:FBgn0000370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 929; ATF-4; atf4; Atf4; ATF4; ATF4/crc; CG8669; Crc; dATF-4; dAtf4; dATF4; DM6; Dmel\CG8669; Ire1; l(2)crc
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in several processes, including PERK-mediated unfolded protein response; instar larval or pupal development; and positive regulation of JNK cascade. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including LNv neurons; embryonic/larval anterior spiracle; embryonic/larval central nervous system; embryonic/larval salivary gland; and fat body. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to several human genes including ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 39C2-39C3; 2-54 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21310866..21319527)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21310866..21319527)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
Title: Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila.
Title: ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila.
Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
Title: Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.
ATF4 activation reprograms nuclear gene expression and contributes to neuronal dysfunction
Title: Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate.
ATF4 regulates the expression of one-carbon metabolism genes SHMT2 and NMDMC as a protective response to mitochondrial toxicity.
Title: dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
Title: 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.
Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2.
Title: Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2.
The roles of crc and dimmed genes on the expression of diverse hormones in D. melanogaster and reported.
Title: Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

mobile_element

Loc: 21312573-21312651 mobile_element_type = transposon:INE-1{}4067
Loc: 21317491-21317796 mobile_element_type = transposon:INE-1{}4069

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in PERK-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupariation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pupation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trehalose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: cryptocephal

Names: CG8669-PA; CG8669-PB; CG8669-PE; CG8669-PF; crc-PA; crc-PB; crc-PE; crc-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

21310866..21319527

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273743.1 → NP_001260672.1 cryptocephal, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260672.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NIR4, Q9VID3

Conserved Domains (1) summary

cd14692
Location:313 → 374

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
NM_080158.3 → NP_524897.1 cryptocephal, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524897.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NIR4, Q9VID3

Related

FBpp0081040

Conserved Domains (1) summary

cd14692
Location:313 → 374

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
NM_001273744.1 → NP_001260673.1 cryptocephal, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260673.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBF8, Q9NIR4

Conserved Domains (1) summary

cd14692
Location:304 → 365

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
NM_165374.2 → NP_724333.1 cryptocephal, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724333.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NIR3

Related

FBpp0081041

Conserved Domains (1) summary

cd14692
Location:230 → 291

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain