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    NEO1 neogenin 1 [ Homo sapiens ]

    Gene ID: 4756, updated on 11-May-2012
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    Summary

    Official Symbol
    NEO1provided by HGNC
    Official Full Name
    neogenin 1provided by HGNC
    Primary source
    HGNC:7754
    See related
    Ensembl:ENSG00000067141; HPRD:03549; MIM:601907; Vega:OTTHUMG00000133509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NGN; IGDCC2; DKFZp547A066; DKFZp547B146
    Summary
    This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
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    Genomic context

    Location :
    15q22.3-q23
    Sequence :
    Chromosome: 15; NC_000015.9 (73344825..73597547)
    See NEO1 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287559 Neighboring gene ADP-dependent glucokinase Neighboring gene nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogene Neighboring gene nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogene Neighboring gene FK506 binding protein 1A, 12kDa pseudogene 2 Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 4 Neighboring gene chromosome 15 open reading frame 60 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Neogenin, a receptor for bone morphogenetic proteins. Hagihara M, et al. J Biol Chem, 2011 Feb 18. PMID 21149453.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å. Yang F, et al. J Struct Biol, 2011 Apr. PMID 20971194.
    5. Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain. Bradford D, et al. J Comp Neurol, 2010 Aug 15. PMID 20575069.

    See all (28) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B.
      Title: [Correlation of netrin-1 expression with invasion of extra villous trophoblasts].
    2. Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer.
      Title: Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å.
    3. neogenin negatively regulates the functions of BMP and that this effect of neogenin is mediated by the activation of RhoA.
      Title: Neogenin, a receptor for bone morphogenetic proteins.
    4. results show that different isoforms of hemojuvelin may play unique physiological roles through defined interactions with distinct signaling proteins such as BMP2 and neogenin, and demonstrate that some of these interactions are defective.
      Title: Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.
    5. This study supports the hypothesis that, as in the embryo, neogenin regulates fundamental signalling pathways important for neurogenesis in the adult mouse and human forebrain.
      Title: Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    7. Results support that hepatic neogenin possesses two functions, mediation of cellular HJV release, and stimulation of HJV-enhanced hepcidin expression.
      Title: Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.
    8. Results show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin.
      Title: Neogenin regulates neuronal survival through DAP kinase.
    9. neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface
      Title: Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.
    10. HJV-induced BMP signaling and hepcidin expression are not altered by neogenin overexpression or by inhibition of endogenous neogenin expr
      Title: Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002490.1 NP_004337.2 CASP3    BIND  PubMed Neogenin interacts with Caspase 3. This interaction was modelled on a demonstrated interaction between human Neogenin and Caspase 3 from an unspecified species. 
    NP_002490.1 PTK2    BIND  PubMed FAK interacts with Neogenin. 
    Q92859 O95631 NTN1    HPRD  PubMed  
    Q92859 O00634 NTN3    HPRD  PubMed  
    Q92859 Q00169 PITPNA    HPRD  PubMed  
    Q92859 Q05397 PTK2    HPRD  PubMed  
    BioGRID:110830 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110830 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    neogenin
    Names
    neogenin
    neogenin homolog 1
    immunoglobulin superfamily DCC subclass member 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016965.1 RefSeqGene

      Range
      5001..257723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172623.1 → NP_001166094.1  neogenin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB209412, AC068397, AL355708, BC143270, DB458571
      Consensus CDS
      CCDS53957.1
      UniProtKB/TrEMBL
      Q59FP8
      Related
      ENSP00000453317, OTTHUMP00000248617, ENST00000560262, OTTHUMT00000418955
      Conserved Domains (7) summary
      cd00063
      Location:539 – 628
      Blast Score: 186
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:266 – 334
      Blast Score: 160
      Ig; Immunoglobulin domain
      cd04979
      Location:166 – 242
      Blast Score: 117
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      cd05722
      Location:54 – 148
      Blast Score: 440
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      cd05723
      Location:357 – 427
      Blast Score: 382
      Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
      pfam06583
      Location:1156 – 1408
      Blast Score: 596
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:341 – 427
      Blast Score: 210
      I-set; Immunoglobulin I-set domain

    2. NM_001172624.1 → NP_001166095.1  neogenin isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB209412, AC068397, AL355708, BC143271, DB458571
      UniProtKB/TrEMBL
      B7ZKN0
      UniProtKB/TrEMBL
      Q59FP8
      Related
      ENSP00000453200, OTTHUMP00000248618, ENST00000558964, OTTHUMT00000418956
      Conserved Domains (7) summary
      cd00063
      Location:539 – 628
      Blast Score: 185
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:266 – 334
      Blast Score: 160
      Ig; Immunoglobulin domain
      cd04979
      Location:166 – 242
      Blast Score: 117
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      cd05722
      Location:54 – 148
      Blast Score: 439
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      cd05723
      Location:357 – 427
      Blast Score: 384
      Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
      pfam06583
      Location:1145 – 1450
      Blast Score: 750
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:341 – 427
      Blast Score: 211
      I-set; Immunoglobulin I-set domain

    3. NM_002499.3 → NP_002490.2  neogenin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB209412, AC068397, AL355708, BC117161, DB458571
      Consensus CDS
      CCDS10247.1
      UniProtKB/TrEMBL
      Q59FP8
      UniProtKB/Swiss-Prot
      Q92859
      Related
      ENSP00000261908, ENST00000261908
      Conserved Domains (7) summary
      cd00063
      Location:539 – 628
      Blast Score: 185
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:266 – 334
      Blast Score: 160
      Ig; Immunoglobulin domain
      cd04979
      Location:166 – 242
      Blast Score: 117
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      cd05722
      Location:54 – 148
      Blast Score: 439
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      cd05723
      Location:357 – 427
      Blast Score: 384
      Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
      pfam06583
      Location:1156 – 1461
      Blast Score: 749
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:341 – 427
      Blast Score: 211
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      73344825..73597547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      50240408..50428957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC068397.6 (56994..111886) None
    genomic AC104420.2 (86959..178755) None
    genomic AC129980.6 None
    genomic CH471082.1 EAW77923.1
      EAW77924.1
    mRNA AB209412.1 BAD92649.1
    mRNA AL355708.1 None
    mRNA AL359597.1 None
    mRNA AL390182.1 None
    mRNA BC117161.1 AAI17162.1
    mRNA BC143270.1 AAI43271.1
    mRNA BC143271.1 AAI43272.1
    mRNA BC143279.1 None
    mRNA BM564445.1 None
    mRNA DB458571.2 None
    mRNA DB478373.1 None
    mRNA U61262.1 AAB17263.1
    mRNA U72391.1 AAC51287.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59FP8 GenPept UniProtKB/TrEMBL:Q59FP8
    Q92859.2 GenPept UniProtKB/Swiss-Prot:Q92859
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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