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NEK3 NIMA related kinase 3 [ Homo sapiens (human) ]

Gene ID: 4752, updated on 26-May-2016
Official Symbol
NEK3provided by HGNC
Official Full Name
NIMA related kinase 3provided by HGNC
Primary source
HGNC:HGNC:7746
See related
Ensembl:ENSG00000136098 HPRD:04954; MIM:604044; Vega:OTTHUMG00000016958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPK36
Summary
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Annotation information
Note: Available sequence data supports two haplotypes in the human population that differ by a 1 nt indel at the end of exon 10. Both haplotypes appear to encode functional proteins via alternative splicing of exon 11. The CHM1_1.1 and HuRef assemblies lack the extra nt and express a full-length protein lacking exon 11. [23 Apr 2014]
Orthologs
Location:
13q14.13
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (52132643..52159861, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52706779..52733996, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ALG11, alpha-1,2-mannosyltransferase Neighboring gene UTP14, small subunit processome component homolog C (S. cerevisiae) Neighboring gene NIMA related kinase 5 Neighboring gene uncharacterized LOC101929657 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 5 Neighboring gene thrombospondin type 1 domain containing 1 pseudogene 1 Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC29949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
 
mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of tubulin deacetylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
serine/threonine-protein kinase Nek3
Names
HSPK 36
NIMA (never in mitosis gene a)-related kinase 3
NIMA-related kinase 3
glycogen synthase A kinase
hydroxyalkyl-protein kinase
never in mitosis A-related kinase 3
nimA-related protein kinase 3
phosphorylase B kinase kinase
NP_001139571.1
NP_002489.1
NP_689933.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146099.1NP_001139571.1  serine/threonine-protein kinase Nek3 isoform b

    See identical proteins and their annotated locations for NP_001139571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. This variant represents an alternate haplotype that lacks an 'A' at position 1253. This haplotype is not encoded by the reference assembly.
    Source sequence(s)
    AB072828, AI026881, DA733733, DB185803
    UniProtKB/Swiss-Prot
    P51956
    Conserved Domains (2) summary
    cd08219
    Location:3257
    STKc_Nek3; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3
    smart00220
    Location:4252
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_002498.2NP_002489.1  serine/threonine-protein kinase Nek3 isoform a

    See identical proteins and their annotated locations for NP_002489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL139082, BC019916
    Consensus CDS
    CCDS73576.1
    UniProtKB/Swiss-Prot
    P51956
    Related
    ENSP00000480328, OTTHUMP00000276188, ENST00000610828, OTTHUMT00000045046
    Conserved Domains (2) summary
    cd08219
    Location:3257
    STKc_Nek3; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3
    smart00220
    Location:4252
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. NM_152720.2NP_689933.1  serine/threonine-protein kinase Nek3 isoform a

    See identical proteins and their annotated locations for NP_689933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI209040, AK131359, AK290259, AL139082, H15146
    Consensus CDS
    CCDS73576.1
    UniProtKB/Swiss-Prot
    P51956
    UniProtKB/TrEMBL
    Q6ZN64
    Related
    ENSP00000484443, ENST00000618534
    Conserved Domains (2) summary
    cd08219
    Location:3257
    STKc_Nek3; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3
    smart00220
    Location:4252
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RNA

  1. NR_027415.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the splice pattern of variant 1 but without the extra 'A' found in the alternate haplotype. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL139082, AW364762, BM675414, BX395059, CV029372, DA407862, DB185803

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    52132643..52159861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    52674859..52702079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)