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FLOT1 flotillin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 474831, updated on 5-Mar-2024

Summary

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Official Symbol
FLOT1provided by VGNC
Official Full Name
flotillin 1provided by VGNC
Primary source
VGNC:VGNC:40903
See related
Ensembl:ENSCAFG00845008046
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (661078..671802, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (655207..665931, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (656440..667178, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (519006..529724, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (587853..598598, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene tubulin beta class I Neighboring gene immediate early response 3 Neighboring gene uncharacterized LOC102157048 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Flotillins are involved in the polarization of primitive and mature hematopoietic cells. Rajendran L, et al. PLoS One, 2009 Dec 22. PMID 20027317, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in positive regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
flotillin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    661078..671802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038682930.1 → XP_038538858.1  flotillin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L0C8, A0A8C0RE82, A0A8I3NJ91
    Related
    ENSCAFP00845011048.1, ENSCAFT00845014249.1
    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_038682932.1 → XP_038538860.1  flotillin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0C8
    Related
    ENSCAFP00845011089.1, ENSCAFT00845014313.1
    Conserved Domains (2) summary
    COG2268
    Location:3 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 96
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. XM_038682931.1 → XP_038538859.1  flotillin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L0C8, A0A8C0RE82, A0A8I3NJ91
    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    519006..529724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038491273.1 → XP_038347201.1  flotillin-1 isoform X1

    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_038491275.1 → XP_038347203.1  flotillin-1 isoform X2

    Conserved Domains (2) summary
    COG2268
    Location:3 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 96
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. XM_038491274.1 → XP_038347202.1  flotillin-1 isoform X1

    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    587853..598598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038617337.1 → XP_038473265.1  flotillin-1 isoform X1

    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_038617339.1 → XP_038473267.1  flotillin-1 isoform X2

    Conserved Domains (2) summary
    COG2268
    Location:3 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 96
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. XM_038617338.1 → XP_038473266.1  flotillin-1 isoform X1

    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    656440..667178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038553446.1 → XP_038409374.1  flotillin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L0C8, A0A8C0RE82, A0A8I3NJ91
    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_038553448.1 → XP_038409376.1  flotillin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0C8
    Conserved Domains (2) summary
    COG2268
    Location:3 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 96
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. XM_038553447.1 → XP_038409375.1  flotillin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0L0C8, A0A8C0RE82, A0A8I3NJ91
    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    655207..665931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_843685.6 → XP_848778.1  flotillin-1 isoform X1

    See identical proteins and their annotated locations for XP_848778.1

    UniProtKB/TrEMBL
    A0A8C0L0C8, A0A8C0RE82, A0A8I3NJ91
    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_005627113.4 → XP_005627170.1  flotillin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0L0C8
    Conserved Domains (2) summary
    COG2268
    Location:3 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 96
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. XM_005627112.4 → XP_005627169.1  flotillin-1 isoform X1

    See identical proteins and their annotated locations for XP_005627169.1

    UniProtKB/TrEMBL
    A0A8C0L0C8, A0A8C0RE82, A0A8I3NJ91
    Conserved Domains (2) summary
    COG2268
    Location:4 → 419
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein
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