mus205 mutagen-sensitive 205 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: mus205provided by Flybase
Official Full Name: mutagen-sensitive 205provided by Flybase
Primary source: FLYBASE:FBgn0002891
Locus tag: Dmel_CG1925
Gene type: protein coding
RNA name: mutagen-sensitive 205
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 154926_at; AAF59191; CG1925; DhRev3; Dmel\CG1925; Dmpolzeta; DmREV3; mus 205; mus(2)205; mus-205; Mus205

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Genomic context

Location :: 43E17-43E17; 2-54.9 cM

Sequence :: Chromosome: 2R; NT_033778.3 (3680757..3688549)

See mus205 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:70663	BioGRID:67866	CG13627	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:58147	CG1999	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:69651	E5	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:61650	Mlh1	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:65436	Rab8	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:63243	fd59A	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:68259	fkh	BioGRID	PubMed	Two-hybrid
BioGRID:70663	BioGRID:65883	rev7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70663	BioGRID:65697	srpk79D	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the mus205 gene: The mus205 gene is conserved in human, , dog, cow, mouse, rat, chicken, zebrafish, C.elegans, , and .

Pathways from BioSystems

DNA Damage Bypass, organism-specific biosystem (from REACTOME)
DNA Damage Bypass, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA polymerase zeta complex, organism-specific biosystem (from KEGG)
DNA polymerase zeta complex, organism-specific biosystemStructural complex; Genetic information processing; DNA polymerase
DNA polymerase zeta complex, conserved biosystem (from KEGG)
DNA polymerase zeta complex, conserved biosystemStructural complex; Genetic information processing; DNA polymerase
Fanconi anemia pathway, organism-specific biosystem (from KEGG)
Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
Fanconi anemia pathway, conserved biosystem (from KEGG)
Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Translesion synthesis by DNA polymerases bypassing lesion on DNA template, organism-specific biosystem (from REACTOME)
Translesion synthesis by DNA polymerases bypassing lesion on DNA template, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translesion synthesis by Pol zeta, organism-specific biosystem (from REACTOME)
Translesion synthesis by Pol zeta, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT 3'-5' exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
DNA binding	IEA Inferred from Electronic Annotation more info
DNA-directed DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
DNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
DNA-directed DNA polymerase activity	NAS Non-traceable Author Statement more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
DNA replication	NAS Non-traceable Author Statement more info
translesion synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
zeta DNA polymerase complex	ISS Inferred from Sequence or Structural Similarity more info
zeta DNA polymerase complex	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG1925 gene product from transcript CG1925-RA

Names: CG1925-PA; mus205-PA; mutagen-sensitive 205

NP_524881.2

EC 2.7.7.7

unusual splice

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

3680757..3688549

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080142.2 → NP_524881.2 mutagen-sensitive 205 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9GSR1

Related

FBpp0087907, FBtr0088831

Conserved Domains (5) summary

cd05778
Location:1297 – 1518
Blast Score: 748

DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase

cd05534
Location:1550 – 2000
Blast Score: 2085

POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...

PTZ00166
Location:20 – 196
Blast Score: 235

PTZ00166; DNA polymerase delta catalytic subunit; Provisional

pfam00136
Location:1550 – 1990
Blast Score: 823

DNA_pol_B; DNA polymerase family B

pfam14260
Location:2041 – 2107
Blast Score: 179

zf-C4pol; C4-type zinc-finger of DNA polymerase delta