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metH 5-methyltetrahydrofolate--homocystein methyltransferase MetH [ Mycobacterium bovis BCG str. Pasteur 1173P2 ]

Gene ID: 4696452, updated on 12-Apr-2014
Gene symbol
metH
Gene description
5-methyltetrahydrofolate--homocystein methyltransferase MetH
Locus tag
BCG_2141c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium bovis BCG str. Pasteur 1173P2 (strain: BCG Pasteur 1173P2)
Lineage
Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Sequence :
NC_008769.1 (2362499..2366077, complement)

NC_008769.1Genomic Context describing neighboring genes Neighboring gene ATP phosphoribosyltransferase Neighboring gene phosphoribosyl-ATP pyrophosphatase Neighboring gene PPE family protein Neighboring gene hypothetical protein Neighboring gene PE-PGRS family protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Names
5-methyltetrahydrofolate--homocystein methyltransferase MetH
YP_978230.1
  • Differs from Rv2124c by 1aa, V752I

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_008769.1

    Range
    2362499..2366077, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_978230.1 5-methyltetrahydrofolate--homocystein methyltransferase MetH [Mycobacterium bovis BCG str. Pasteur 1173P2]

    See proteins identical to YP_978230.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A1KKG7
    Conserved Domains (5) summary
    COG0646
    Location:6314
    Blast Score: 1146
    MetH; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    TIGR02082
    Location:171192
    Blast Score: 4737
    metH; 5-methyltetrahydrofolate--homocysteine methyltransferase
    cd00740
    Location:343597
    Blast Score: 968
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:644856
    Blast Score: 912
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:10591192
    Blast Score: 129
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

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