NDN necdin homolog (mouse) [Homo sapiens] - Gene

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Summary

Official Symbol: NDNprovided by HGNC
Official Full Name: necdin homolog (mouse)provided by HGNC
Primary source: HGNC:7675
See related: Ensembl:ENSG00000182636; HPRD:03667; MIM:602117; Vega:OTTHUMG00000129161
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PWCR; HsT16328
Summary: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 15q11.2-q12

Sequence :: Chromosome: 15; NC_000015.9 (23930554..23932450, complement)

See NDN in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In pre-adipocytes, necdin over-expression inhibits adipogenesis, while reducing necdin levels enhances adipogenic differentiation in tissue culture cell
Title: Loss of the Prader-Willi obesity syndrome protein necdin promotes adipogenesis.
Necdin, a negative growth regulator,identified as a novel STAT3 target gene, whose expression is down-regulated at the mRNA and protein levels when STAT3 is constitutively active.
Title: Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer.
Necdin is implicated through the TNF-receptor 1 pathway in the developmental death of motoneuron
Title: Necdin protects embryonic motoneurons from programmed cell death.
rare variant of necdin (p.V318A) was described in a family with Kallmann syndrome Familial segregation and in vitro analysis suggested that this non-synonymous variant did not have a direct causative role in hypogonadism phenotype.
Title: Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism.
Data suggest that the effects of necdin deletion on the developing nervous system may depend on the relative expression of p75NTR and TrkA in the cells of particular regions of the nervous system.
Title: Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.
Necdin is a key protein regulating polarization of the cytoskeleton and myosin activation during development.
Title: Loss of Necdin impairs myosin activation and delays cell polarization.
The necdin gene is imprinted, with preferential expression from the paternal allele in human and mouse.
Title: The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse.
Confirmation of NDN as a tumor suppressor may have implications for monitoring of PWS patients and could present a novel cancer therapeutic target
Title: Necdin: a multi functional protein with potential tumor suppressor role?
regulates neuronal development. (review)
Title: [Regulation of neuronal development by the imprinted gene Necdin].
Data suggest that Nogo-A is a novel necdin binding protein and inhibits necdin-accelerated neuronal neurite outgrowth by sequestering necdin in the cytoplasm.
Title: Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm.

Submit: New GeneRIF Correction See all (15)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
Q99608	P51690	ARSE	HPRD	PubMed
Q99608	Q01094	E2F1	HPRD	PubMed
Q99608	Q16254	E2F4	HPRD	PubMed
Q99608	Q16665	HIF1A	HPRD	PubMed
Q99608	Q00839	HNRNPU	HPRD	PubMed
Q99608	P01583	IL1A	HPRD	PubMed
Q99608	Q99608	NDN	HPRD	PubMed
Q99608	P08138	NGFR	HPRD	PubMed
Q99608	P53384	NUBP1	HPRD	PubMed
Q99608	Q02818	NUCB1	HPRD	PubMed
Q99608	P80303	NUCB2	HPRD	PubMed
Q99608	Q8NG27	PJA1	HPRD	PubMed
Q99608	P04637	TP53	HPRD	PubMed
BioGRID:110772	BioGRID:106908	ARSE	BioGRID	PubMed	Two-hybrid
BioGRID:110772	BioGRID:107031	AUP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:118992	CERS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:108063	DHCR7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110772	BioGRID:108276	EGFR	BioGRID	PubMed	PCA
BioGRID:110772	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:110772	BioGRID:109768	IL1A	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110772	BioGRID:110772	NDN	BioGRID	PubMed	Two-hybrid
BioGRID:110772	BioGRID:110870	NGFR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110772	BioGRID:110762	NUBP1	BioGRID	PubMed	Two-hybrid
BioGRID:110772	BioGRID:110979	NUCB2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110772	BioGRID:112119	RPS11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:118968	SEC61A1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:121810	SRPRB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:120462	TMEM33	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:113010	TP53	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110772	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110772	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
gamma-tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
axon extension involved in development	IEA Inferred from Electronic Annotation more info
axonal fasciculation	IEA Inferred from Electronic Annotation more info
central nervous system development	IEA Inferred from Electronic Annotation more info
genetic imprinting	IEA Inferred from Electronic Annotation more info
glial cell migration	IEA Inferred from Electronic Annotation more info
multicellular organismal homeostasis	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
nerve growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
nervous system development	TAS Traceable Author Statement more info	PubMed
neuron development	IEA Inferred from Electronic Annotation more info
neuron migration	IEA Inferred from Electronic Annotation more info
post-embryonic development	IEA Inferred from Electronic Annotation more info
regulation of growth	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
respiratory system process	IEA Inferred from Electronic Annotation more info
sensory perception of pain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell projection	IEA Inferred from Electronic Annotation more info
centrosome	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: necdin

Names: necdin

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009380.1 RefSeqGene

Range

5001..6897

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002487.2 → NP_002478.1 necdin

Status: REVIEWED

Source sequence(s)

AB007828

Consensus CDS

CCDS10014.1

UniProtKB/Swiss-Prot

Q99608

Related

ENSP00000332643, OTTHUMP00000159437, ENST00000331837, OTTHUMT00000251226

Conserved Domains (1) summary

pfam01454
Location:105 – 275
Blast Score: 436

MAGE; MAGE family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

23930554..23932450, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

2066175..2068071, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB007828.1	BAA22660.1
genomic	AC124309.7 (55965..57861)	None
genomic	AF001013.1	None
genomic	CH471151.1	EAW57610.1
mRNA	AK129654.1	None
mRNA	AK312779.1	BAG35642.1
mRNA	BC008750.1	AAH08750.1
mRNA	U35139.1	AAB39469.1
other-genetic	HQ448156.1	ADQ32637.1