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    ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) [ Homo sapiens ]

    Gene ID: 468, updated on 19-May-2012
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    Summary

    Official Symbol
    ATF4provided by HGNC
    Official Full Name
    activating transcription factor 4 (tax-responsive enhancer element B67)provided by HGNC
    Primary source
    HGNC:786
    See related
    Ensembl:ENSG00000128272; HPRD:06817; MIM:604064; Vega:OTTHUMG00000151099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CREB2; TXREB; CREB-2; TAXREB67
    Summary
    This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
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    Genomic context

    Location :
    22q13.1
    Sequence :
    Chromosome: 22; NC_000022.10 (39916569..39918691)
    See ATF4 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase Neighboring gene Smith-Magenis syndrome chromosome region, candidate 7-like Neighboring gene ribosomal protein S19 binding protein 1 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1I subunit

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Combinatorial control of ATF4-dependent gene transcription in osteoblasts. St-Arnaud R, et al. Ann N Y Acad Sci, 2011 Nov. PMID 22082360.
    2. Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma. Fan CF, et al. Mol Med Report, 2012 Feb. PMID 22052162.
    3. Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties. Caselli E, et al. Arch Virol, 2012 Jan. PMID 22016052.
    4. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Wang Q, et al. Cancer Res, 2011 Dec 15. PMID 22007000.
    5. Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins. John L, et al. PLoS One, 2011. PMID 21966512.

    See all (101) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. elevated expression of p-CREB-2 (ser 245) may potentially contribute to carcinogenesis and cancer development of breast carcinoma
      Title: Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma.
    2. Coexistence of PHD1 stabilized ATF4, as opposed to the destabilization of ATF4 by PHD3.
      Title: PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.
    3. Data show that signaling via the androgen receptor and ATF4 pathways regulates expression of the amino acid transporters LAT1 and LAT3, thereby coordinating their increased expression in prostate cancer cells.
      Title: Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.
    4. HHV-8 upregulates ATF4 expression and induces MCP-1 production and proangiogenic properties in endothelial cells.
      Title: Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties.
    5. ATF4 protein binds and activates the AARE regulatory sites of the CHOP promoter. ORF2 expression also leads to increased phosphorylation of eIF2alpha that in turn initiates the translation of ATF4 mRNA.
      Title: Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins.
    6. [review] First evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).
      Title: Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
    7. we show that RPL41 induces ATF4 phosphorylation and rapid degradation in the proteasome
      Title: Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress.
    8. stress-induced upregulation of parkin is mediated by activating transcription factor 4
      Title: Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
    9. DKK1 is a novel target gene in the response to amino acid deficiency and that the expression of DKK1 is up-regulated through an ATF4-independent and an ERK-dependent pathway.
      Title: Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation.
    10. ATF4 binding to the COX2 promoter plays a critical role in HBx-mediated COX2 induction.
      Title: Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4.
    Submit: New GeneRIF Correction See all (59)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001666.2 DISC1    BIND  PubMed An unspecified isoform of DISC1 interacts with ATF4. 
    NP_877962.1 NP_061132.1 DISC1    BIND  PubMed DISC-1 interacts with ATF4. 
    NP_877962.1 NP_066981.2 TRIB3    BIND  PubMed SKIP3 interacts with ATF4. 
    P18848 Q9BWC9 CCDC106    HPRD  PubMed  
    P18848 P17676 CEBPB    HPRD  PubMed  
    P18848 P53567 CEBPG    HPRD  PubMed  
    P18848 Zhangfei protein CREBZF    HPRD  PubMed  
    P18848 O43293 DAPK3    HPRD  PubMed  
    P18848 P35638 DDIT3    HPRD  PubMed  
    P18848 Q9NRI5 DISC1    HPRD  PubMed  
    P18848 O75899 GABBR2    HPRD  PubMed  
    P18848 Q13227 GPS2    HPRD  PubMed  
    P18848 P13984 GTF2F2    HPRD  PubMed  
    P18848 P05412 JUN    HPRD  PubMed  
    P18848 O95751 LDOC1    HPRD  PubMed  
    P18848 Q14494 NFE2L1    HPRD  PubMed  
    P18848 Q16236 NFE2L2    HPRD  PubMed  
    P18848 P19387 POLR2C    HPRD  PubMed  
    P18848 Pentatricopeptide repeat domain 3 PTCD3    HPRD  PubMed  
    P18848 Q9BQ50 TREX2    HPRD  PubMed  
    P18848 Q96RU7 TRIB3    HPRD  PubMed  
    P18848 P02766 TTR    HPRD  PubMed  
    BioGRID:106958 BioGRID:106957 ATF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106958 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106958 BioGRID:118952 CCDC106    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:107482 CEBPE    BioGRID  PubMed Co-localization 
    BioGRID:106958 BioGRID:107777 CREBBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106958 BioGRID:198669 Cebpb    BioGRID  PubMed Co-crystal Structure 
    BioGRID:106958 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:123822 EIF2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106958 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106958 BioGRID:116887 FBXW11    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106958 BioGRID:108825 GABBR1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106958 BioGRID:114938 GABBR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106958 BioGRID:109132 GPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:116225 GTF2A1L    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:109214 GTF2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106958 BioGRID:109218 GTF2F2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106958 BioGRID:109928 JUN    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106958 BioGRID:114375 KAT2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106958 BioGRID:117169 LDOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:111428 POLR2C    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106958 BioGRID:120366 PTCD3    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106958 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106958 BioGRID:116388 TREX2    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:121756 TRIB3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106958 BioGRID:114333 TRIM24    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 
    BioGRID:106958 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106958 BioGRID:113552 ZNF226    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Chaperone Genes by ATF6-alpha, organism-specific biosystem (from REACTOME)
      Activation of Chaperone Genes by ATF6-alpha, organism-specific biosystemThe N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription...
    • Activation of Chaperones by ATF6-alpha, organism-specific biosystem (from REACTOME)
      Activation of Chaperones by ATF6-alpha, organism-specific biosystemATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions ...
    • Activation of Genes by ATF4, organism-specific biosystem (from REACTOME)
      Activation of Genes by ATF4, organism-specific biosystemATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • PERK regulated gene expression, organism-specific biosystem (from REACTOME)
      PERK regulated gene expression, organism-specific biosystemPERK is a single-pass transmembrane protein located in the endoplasmic reticulum (ER) membrane such that the N-terminus of PERK is luminal and the C-terminus is cytosolic. PERK is maintained in an in...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Unfolded Protein Response, organism-specific biosystem (from REACTOME)
      Unfolded Protein Response, organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of signaling protein activity involved in unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    cellular amino acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-4
    Names
    cyclic AMP-dependent transcription factor ATF-4
    DNA-binding protein TAXREB67
    cAMP response element-binding protein 2
    cAMP-dependent transcription factor ATF-4
    cAMP-responsive element-binding protein 2
    cyclic AMP-responsive element-binding protein 2
    tax-responsive enhancer element-binding protein 67
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001675.2 → NP_001666.2  cyclic AMP-dependent transcription factor ATF-4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      D90209
      Consensus CDS
      CCDS13996.1
      UniProtKB/Swiss-Prot
      P18848
      UniProtKB/TrEMBL
      Q96AQ3
      Related
      ENSP00000336790, OTTHUMP00000199131, ENST00000337304, OTTHUMT00000321305
      Conserved Domains (1) summary
      cl02576
      Location:290 – 339
      Blast Score: 91
      bZIP_1; bZIP transcription factor

    2. NM_182810.1 → NP_877962.1  cyclic AMP-dependent transcription factor ATF-4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK057751
      Consensus CDS
      CCDS13996.1
      UniProtKB/Swiss-Prot
      P18848
      UniProtKB/TrEMBL
      Q96AQ3
      Related
      ENSP00000379912, ENST00000396680
      Conserved Domains (1) summary
      cl02576
      Location:290 – 339
      Blast Score: 91
      bZIP_1; bZIP transcription factor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      39916569..39918691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      22881158..22883280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL022312.7 CAB45284.1
    genomic CH471095.1 EAW60341.1
      EAW60342.1
    mRNA AK057751.1 None
    mRNA AK296028.1 BAG58796.1
    mRNA BC008090.1 AAH08090.1
    mRNA BC011994.1 AAH11994.1
    mRNA BC016855.2 AAH16855.1
    mRNA BC022088.2 AAH22088.1
    mRNA BC024775.1 AAH24775.1
    mRNA BC044895.1 AAH44895.1
    mRNA BC073754.1 AAH73754.1
    mRNA BC073990.1 AAH73990.1
    mRNA CR450353.1 CAG29349.1
    mRNA CR456384.1 CAG30270.1
    mRNA D90209.1 BAA14234.1
    mRNA M86842.1 AAA52071.1
    other-genetic CU012942.1 CAK54373.1
    other-genetic CU013230.1 CAK54672.1
    other-genetic DQ891758.2 ABM82684.1
    other-genetic DQ894942.2 ABM85868.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18848.3 GenPept UniProtKB/Swiss-Prot:P18848
    Q6ICP0 GenPept UniProtKB/TrEMBL:Q6ICP0
    Q96AQ3 GenPept UniProtKB/TrEMBL:Q96AQ3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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    Research Materials
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      Supplemental Content

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