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    NASP nuclear autoantigenic sperm protein (histone-binding) [ Homo sapiens (human) ]

    Gene ID: 4678, updated on 5-May-2013
    Official Symbol
    NASPprovided by HGNC
    Official Full Name
    nuclear autoantigenic sperm protein (histone-binding)provided by HGNC
    Primary source
    HGNC:7644
    Locus tag
    RP4-697E16.3
    See related
    Ensembl:ENSG00000132780; HPRD:04423; MIM:603185; Vega:OTTHUMG00000007826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLB7527; PRO1999
    Summary
    This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
    Location :
    1p34.1
    Sequence :
    Chromosome: 1; NC_000001.10 (46049660..46084578)
    See NASP in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) Neighboring gene coiled-coil domain containing 17 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene ribosomal protein S15a pseudogene 10

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities. Finn RM, et al. FASEB J, 2012 Dec. PMID 22968912.
    3. A catalogue of putative HIV-1 protease host cell substrates. Impens F, et al. Biol Chem, 2012 Sep. PMID 22944692.
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    5. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.

    See all (58) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies indicate that histone chalerones nucleoplasmin (NPM2/NPM3) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families.
      Title: Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.
    2. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
      Title: MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
    3. sNASP interacts with linker and core histones through distinct structural domains.
      Title: The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms.
    4. The insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand.
      Title: A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.
    5. tNASP is critical for the survival of prostate cancer cells; targeting tNASP expression can lead to a new approach for prostate cancer treatment.
      Title: Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells.
    6. NASP and RCAS1 proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 was less frequently expressed
      Title: Analysis of the expression of human tumor antigens in ovarian cancer tissues.
    7. A deletion analysis of sNASP revealed that the central region, amino acid residues 26-325, of sNASP is responsible for nucleosome assembly in vitro.
      Title: Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP).
    8. NASP belongs to a network of genes and gene functions that are critical for cell survival
      Title: Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP.
    9. NASP forms distinct, high specificity complexes with histones H3 and H4.
      Title: Expanded binding specificity of the human histone chaperone NASP.
    10. NASP and the linker histones are key players in the assembly of chromatin after DNA replication
      Title: Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    pol gag-pol Positional proteomics analysis identifies the cleavage of human nuclear autoantigenic sperm protein (histone-binding) (NASP) at amino acid residues 676-677 and 759-760 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P49321 Q02539 HIST1H1A    HPRD  PubMed  
    P49321 P16403 HIST1H1C    HPRD  PubMed  
    P49321 Histone 1 H3g HIST1H3G    HPRD  PubMed  
    P49321 Histone 1 H3h HIST1H3H    HPRD  PubMed  
    P49321 Q71DI3 HIST2H3C    HPRD  PubMed  
    P49321 Q9Y383 LUC7L2    HPRD  PubMed  
    P49321 Q8IYT8 ULK2    HPRD  PubMed  
    BioGRID:110759 BioGRID:106823 AIRE    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    NP_054753.1 ASF1A    BIND  PubMed Asf1a interacts with NASP. This interaction was modeled on a demonstrated interaction between Asf1a from an unspecified species and human NASP. 
    BioGRID:110759 BioGRID:117368 ASF1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110759 BioGRID:115787 ATG7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:107011 ATP6V1C1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:117221 GSPT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110759 BioGRID:115330 HDAC6    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:113946 HIST1H3A    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:110759 BioGRID:113949 HIST1H3E    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110759 BioGRID:113951 HIST1H3G    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:113953 HIST1H3H    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:113955 HIST1H4A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110759 BioGRID:126025 HIST2H3C    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:119646 LUC7L2    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:118166 MAT2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:116440 PNKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:111522 PPP3CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:111553 PRKACA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:111719 PTK2    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:112368 SHMT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:112525 SNX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:116162 STIP1    BioGRID  PubMed Co-fractionation 
    BioGRID:110759 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:112767 TBCD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:112873 TERF2    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:119942 TERF2IP    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110759 BioGRID:115058 ULK2    BioGRID  PubMed Two-hybrid 
    BioGRID:110759 BioGRID:113258 VCP    BioGRID  PubMed Co-fractionation 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC2297, FLJ31599, FLJ35510, MGC19722, MGC20372, DKFZp547F162

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Hsp90 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    blastocyst development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    histone exchange ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Preferred Names
    nuclear autoantigenic sperm protein
    Names
    nuclear autoantigenic sperm protein
    histone H1-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029224.1 RefSeqGene

      Range
      5001..39919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195193.1 → NP_001182122.1  nuclear autoantigenic sperm protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 4), compared to isoform 2.
      Source sequence(s)
      AK291637, AK298893, BC010105, CK300084, CX781565, DC361634
      Consensus CDS
      CCDS55597.1
      UniProtKB/TrEMBL
      B4DQP3
      UniProtKB/TrEMBL
      F5H3J2
      UniProtKB/Swiss-Prot
      P49321
      Conserved Domains (2) summary
      cd00189
      Location:456 – 552
      Blast Score: 104
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam13424
      Location:475 – 552
      Blast Score: 118
      TPR_12; Tetratricopeptide repeat

    2. NM_002482.3 → NP_002473.2  nuclear autoantigenic sperm protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AK291637, BC010105, CK300084, CX781565, DC361634
      Consensus CDS
      CCDS524.1
      UniProtKB/Swiss-Prot
      P49321
      Related
      ENSP00000255120, OTTHUMP00000009513, ENST00000350030, OTTHUMT00000021533
      Conserved Domains (2) summary
      cd00189
      Location:520 – 616
      Blast Score: 101
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam13424
      Location:539 – 616
      Blast Score: 116
      TPR_12; Tetratricopeptide repeat

    3. NM_152298.3 → NP_689511.2  nuclear autoantigenic sperm protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 2. This results in a shorter protein (isoform 3), compared to isoform 2.
      Source sequence(s)
      AK291637, BC053608, CK300084, CX781565, DC361634
      Consensus CDS
      CCDS525.1
      UniProtKB/Swiss-Prot
      P49321
      UniProtKB/TrEMBL
      Q5T626
      Conserved Domains (2) summary
      cd00189
      Location:181 – 277
      Blast Score: 90
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam13424
      Location:200 – 277
      Blast Score: 107
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      46049660..46084578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      44161002..44195831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      46127309..46162228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172164.1: Suppressed sequence

      Description
      NM_172164.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01050862.1 (64503..90121) None
    genomic ABBA01050863.1 None
    genomic AL355480.22 (63260..98178) None
    genomic AMYH01000574.1 (86070..120989) None
    genomic CH471059.2 EAX06964.1
      EAX06965.1
      EAX06966.1
      EAX06967.1
      EAX06968.1
      EAX06969.1
    mRNA AF035191.1 AAD02006.1
    mRNA AK056161.1 None
    mRNA AK092829.1 None
    mRNA AK222778.1 BAD96498.1
    mRNA AK222816.1 BAD96536.1
    mRNA AK291637.1 BAF84326.1
    mRNA AK298893.1 BAG61005.1
    mRNA AK299584.1 BAG61519.1
    mRNA AK308001.1 None
    mRNA AL512718.1 None
    mRNA AL571577.2 None
    mRNA BC003113.1 AAH03113.1
    mRNA BC009933.2 AAH09933.1
    mRNA BC010105.2 AAH10105.1
    mRNA BC011580.1 AAH11580.1
    mRNA BC053608.1 AAH53608.1
    mRNA BT006757.1 AAP35403.1
    mRNA CK300084.1 None
    mRNA CX781565.1 None
    mRNA DC361634.1 None
    mRNA M97856.1 AAA36027.1
    other-genetic DQ893275.2 ABM84201.1
    other-genetic DQ896606.2 ABM87605.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49321.2 GenPept UniProtKB/Swiss-Prot:P49321

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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      • BioProjects
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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