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SERPINA1 serpin family A member 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 467541, updated on 3-Apr-2024

Summary

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Official Symbol
SERPINA1provided by VGNC
Official Full Name
serpin family A member 1provided by VGNC
Primary source
VGNC:VGNC:57260
Locus tag
CK820_G0025082
See related
Ensembl:ENSPTRG00000023666
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human all
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Genomic context

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Location:
chromosome: 14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 15 NC_072413.2 (92378374..92390633, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 14 NC_072412.1 (85663469..85675721, complement)

Chromosome 15 - NC_072413.2Genomic Context describing neighboring genes Neighboring gene serpin family A member 10 Neighboring gene serpin family A member 6 Neighboring gene serpin family A member 11 Neighboring gene serpin family A member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. α1Proteinase inhibitor regulates CD4+ lymphocyte levels and is rate limiting in HIV-1 disease. Bristow CL, et al. PLoS One, 2012. PMID 22363634, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanism underlying the alpha(1)PI deficiency that attends HIV-1 infection, was investigated.
    Title: α1Proteinase inhibitor regulates CD4+ lymphocyte levels and is rate limiting in HIV-1 disease.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-1-antitrypsin
Names
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072413.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    92378374..92390633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009428364.4 → XP_009426639.1  alpha-1-antitrypsin

    See identical proteins and their annotated locations for XP_009426639.1

    UniProtKB/TrEMBL
    A0A2J8QMJ1, A0A2J8QMJ5, A0A6D2WWZ7, H2R1G9
    Conserved Domains (1) summary
    cd02056
    Location:55 → 412
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  2. XM_003314498.5 → XP_003314546.1  alpha-1-antitrypsin

    See identical proteins and their annotated locations for XP_003314546.1

    UniProtKB/TrEMBL
    A0A2J8QMJ1, A0A2J8QMJ5, A0A6D2WWZ7, H2R1G9
    Conserved Domains (1) summary
    cd02056
    Location:55 → 412
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  3. XM_016926677.2 → XP_016782166.1  alpha-1-antitrypsin

    UniProtKB/TrEMBL
    A0A2J8QMJ1, A0A2J8QMJ5, A0A6D2WWZ7, H2R1G9
    Conserved Domains (1) summary
    cd02056
    Location:55 → 412
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  4. XM_009428362.4 → XP_009426637.1  alpha-1-antitrypsin

    See identical proteins and their annotated locations for XP_009426637.1

    UniProtKB/TrEMBL
    A0A2J8QMJ1, A0A2J8QMJ5, A0A6D2WWZ7, H2R1G9
    Conserved Domains (1) summary
    cd02056
    Location:55 → 412
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  5. XM_054666269.1 → XP_054522244.1  alpha-1-antitrypsin

    UniProtKB/TrEMBL
    A0A2J8QMJ1, A0A6D2WWZ7, H2R1G9

  6. XM_009428360.5 → XP_009426635.1  alpha-1-antitrypsin

    See identical proteins and their annotated locations for XP_009426635.1

    UniProtKB/TrEMBL
    A0A2J8QMJ1, A0A2J8QMJ5, A0A6D2WWZ7, H2R1G9
    Conserved Domains (1) summary
    cd02056
    Location:55 → 412
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
Nucleotide Protein
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