PPP1R12A protein phosphatase 1, regulatory subunit 12A [Homo sapiens (human)] - Gene

Summary

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Official Symbol: PPP1R12Aprovided by HGNC
Official Full Name: protein phosphatase 1, regulatory subunit 12Aprovided by HGNC
Primary source: HGNC:7618
See related: Ensembl:ENSG00000058272; HPRD:03606; MIM:602021; Vega:OTTHUMG00000170100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MBS; M130; MYPT1
Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Genomic context

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Location :: 12q15-q21

Sequence :: Chromosome: 12; NC_000012.11 (80167343..80329235, complement)

See PPP1R12A in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Calcineurin may modulate the phosphorylation level of MLC20 by influencing the phosphorylation state of MYPT1 to regulate endothelial barrier function.
Title: Calcineurin regulates endothelial barrier function by interaction with and dephosphorylation of myosin phosphatase.
Mypt1 colocalizes outside the nucleus with Nkx2.5 in a manner dependent on Wnt signaling and Rho-associated protein kinase.
Title: Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/Rho-associated protein kinase-dependent pathway.
These findings provide evidence for the involvement of a particular PP1 complex, PPP1R12A/PP1cdelta, in insulin signaling.
Title: Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway.
Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin.
Title: Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin.
Phosphorylation of MYPT1 (Thr853) changes dynamically with each contraction of the myometrium regulated by Rho-kinase.
Title: Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).
It found deoxyribonucleic acid (DNA) damage-induced LATS1 activation caused PLK1 suppression via the phosphorylation of MYPT1 S445.
Title: LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.
MYPT1 variant 2 shows decreased binding affinity compared to MYPT1 long for radixin (novel MLCP substrate and a member of ERM family proteins).
Title: Molecular characterization of myosin phosphatase in endothelium.
the defective protein level of MYPT1 in the diabetes mellitus (DM) group can partially explain the poor patency of saphenous vein graft harvested from patients with DM.
Title: The defective protein level of myosin light chain phosphatase (MLCP) in the isolated saphenous vein, as a vascular conduit in coronary artery bypass grafting (CABG), harvested from patients with diabetes mellitus (DM).
Myosin phosphatase-targeting subunit 1 controls chromatid segregation.
Title: Myosin phosphatase-targeting subunit 1 controls chromatid segregation.
hHS-M(21) is a heart-specific effector of ROCK and plays a regulatory role in the MYPT1 phosphorylation at Thr-696 by ROCK
Title: Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1.

Submit: New GeneRIF Correction See all (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	Treatment of human brain endothelial cells with Tat markedly elevate GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain	PubMed
nucleocapsid	gag	HIV-1 NC is identified to have a physical interaction with protein phosphatase 1, regulatory subunit 12A (PPP1R12A; YMPT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002471.1	NP_004400.4	DMPK	BIND	PubMed	DMPK interacts with MYPT1. This interaction was modelled on a demonstrated interaction between chicken MYPT1 and DMPK from an unspecified source.
NP_002471.1	NP_004504.3	IL16	BIND	PubMed	The PDZ2 domain of pro-IL-16 interacts with the carboxy terminal of MYPT1.
O14974	Q09013	DMPK	HPRD	PubMed
O14974	Q14005	IL16	HPRD	PubMed
O14974	Q13418	ILK	HPRD	PubMed
O14974	Myosin phosphatase Rho interacting protein	MPRIP	HPRD	PubMed
O14974	P14619	PRKG1	HPRD	PubMed
O14974	P61586	RHOA	HPRD	PubMed
O14974	Q13464	ROCK1	HPRD	PubMed
O14974	O75116	ROCK2	HPRD	PubMed
O14974	P61981	YWHAG	HPRD	PubMed
BioGRID:110742	BioGRID:123290	AARSD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:115403	ACTR3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:115415	ARPC2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:106902	ARRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:117343	ATXN10	BioGRID	PubMed	Two-hybrid
BioGRID:110742	BioGRID:120726	CDV3	BioGRID	PubMed	Co-fractionation
BioGRID:110742	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:198624	Cdk1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:216776	Cep72	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:199254	Dync1h1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110742	BioGRID:199505	Erh	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:117646	FBXO25	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:107208	FMNL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:119613	HDAC7	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110742	BioGRID:231085	Haus3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:109647	IDH3G	BioGRID	PubMed	Co-fractionation
BioGRID:110742	BioGRID:109816	IL16	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110742	BioGRID:116667	KDM1A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:110742	BioGRID:122098	LEPRE1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:125700	LRRK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:110954	NRD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:120236	NSUN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:116335	NUDT5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:119376	NUSAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:120779	OSGEP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:116625	PAXIP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:111223	PFDN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:111226	PFDN5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:111494	PPP1CB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:111578	PRKG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110742	BioGRID:123236	PUS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:238351	Poc1b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:106880	RHOA	BioGRID	PubMed	Co-fractionation
BioGRID:110742	BioGRID:112037	RPA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:121820	RPRD1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:123332	SETD7	BioGRID	PubMed	Biochemical Activity
BioGRID:110742	BioGRID:112373	SIAH2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110742	BioGRID:215561	Sass6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:203518	Stag2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:113027	TPP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:124794	TRIM47	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:116782	TTLL12	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:214351	Trim69	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:121574	XPO5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110742	BioGRID:1205537	gag	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
Long-term potentiation, organism-specific biosystem (from KEGG)
Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Long-term potentiation, conserved biosystem (from KEGG)
Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystem
Mitotic G2-G2/M phases
PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
PLK1 signaling events, organism-specific biosystem
PLK1 signaling events
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe interaction of PLK1 with OPTN (optineurin) provides a negative-feedback mechanism for regulation of PLK1 activity. Phosphorylated PLK1 binds and phosphorylates OPTN associated with the Golgi memb...
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
RhoA signaling pathway, organism-specific biosystem
RhoA signaling pathway
Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Vascular smooth muscle contraction, conserved biosystem (from KEGG)
Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

General gene information

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Markers

A009E41 (e-PCR)
- UniSTS:7482

RH46293 (e-PCR)
- UniSTS:49993

G32488 (e-PCR)
- UniSTS:117073

PPP1R12A_1515 (e-PCR)
- UniSTS:277601

PPP1R12A_v511 (e-PCR)
- UniSTS:277601

RH91540 (e-PCR)
- UniSTS:85896

RH44805 (e-PCR)
- UniSTS:60561

SHGC-56584 (e-PCR)
- UniSTS:38804

RH11236 (e-PCR)
- UniSTS:20421

RH70109 (e-PCR)
- UniSTS:23268

SHGC-84164 (e-PCR)
- UniSTS:104678

SHGC-84179 (e-PCR)
- UniSTS:104679

WI-16785 (e-PCR)
- UniSTS:76267

Homology

Homologs of the PPP1R12A gene: The PPP1R12A gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
14-3-3 protein binding	IDA Inferred from Direct Assay more info
enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
phosphatase regulator activity	IDA Inferred from Direct Assay more info
phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
centrosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic cell cycle	TAS Traceable Author Statement more info
negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell adhesion	IDA Inferred from Direct Assay more info
regulation of myosin-light-chain-phosphatase activity	IDA Inferred from Direct Assay more info
regulation of nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
PTW/PP1 phosphatase complex	IDA Inferred from Direct Assay more info
centrosome	IDA Inferred from Direct Assay more info	PubMed
contractile fiber	IDA Inferred from Direct Assay more info
kinetochore	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 12A

Names: protein phosphatase 1 regulatory subunit 12A; myosin binding subunit; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase myosin-binding subunit; protein phosphatase 1, regulatory (inhibitor) subunit 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143885.1 → NP_001137357.1 protein phosphatase 1 regulatory subunit 12A isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

Source sequence(s)

AC073569, AF458589, AK314193, BC111752

Consensus CDS

CCDS44947.1

UniProtKB/TrEMBL

B2RAH5

UniProtKB/Swiss-Prot

O14974

Related

ENSP00000261207, ENST00000261207

Conserved Domains (3) summary

cd00204
Location:44 – 145
Blast Score: 272

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:44 – 136
Blast Score: 235

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 – 252
Blast Score: 163

Ank_4; Ankyrin repeats (many copies)
NM_001143886.1 → NP_001137358.1 protein phosphatase 1 regulatory subunit 12A isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC073569, AK302692, BC111752

Consensus CDS

CCDS44948.1

UniProtKB/Swiss-Prot

O14974

Conserved Domains (3) summary

cd00204
Location:13 – 165
Blast Score: 251

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:23 – 142
Blast Score: 145

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:112 – 165
Blast Score: 165

Ank_4; Ankyrin repeats (many copies)
NM_001244990.1 → NP_001231919.1 protein phosphatase 1 regulatory subunit 12A isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC018476, AC073569, AC074270

Consensus CDS

CCDS58260.1

UniProtKB/Swiss-Prot

O14974

Related

ENSP00000416769, OTTHUMP00000242813, ENST00000437004, OTTHUMT00000407255

Conserved Domains (3) summary

cd00204
Location:44 – 145
Blast Score: 274

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:44 – 136
Blast Score: 237

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 – 252
Blast Score: 165

Ank_4; Ankyrin repeats (many copies)
NM_001244992.1 → NP_001231921.1 protein phosphatase 1 regulatory subunit 12A isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an exon in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AC018476, AC073569, AC074270

Consensus CDS

CCDS58259.1

UniProtKB/Swiss-Prot

O14974

Conserved Domains (3) summary

cd00204
Location:44 – 145
Blast Score: 272

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:44 – 136
Blast Score: 236

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 – 252
Blast Score: 164

Ank_4; Ankyrin repeats (many copies)
NM_002480.2 → NP_002471.1 protein phosphatase 1 regulatory subunit 12A isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.

Source sequence(s)

AC073569, AK314193, BC111752, DC350703

Consensus CDS

CCDS44947.1

UniProtKB/TrEMBL

B2RAH5

UniProtKB/Swiss-Prot

O14974

Related

ENSP00000389168, OTTHUMP00000242812, ENST00000450142, OTTHUMT00000407254

Conserved Domains (3) summary

cd00204
Location:44 – 145
Blast Score: 272

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:44 – 136
Blast Score: 235

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 – 252
Blast Score: 163

Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p10 Primary Assembly

Range

80167343..80329235, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

77223683..77385520, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018923.1 Alternate CHM1_1.0

Range

80014831..80176663, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB042196.1	BAB39107.1
genomic	ABBA01053499.1 (45914..131788)	None
genomic	ABBA01053500.1	None
genomic	ABBA01053501.1	None
genomic	AC018476.26 (2001..48106)	None
genomic	AC073569.26 (123283..177734)	None
genomic	AC074270.25 (77269..138603)	None
genomic	AMYH01004610.1 (465729..627561)	None
genomic	CH471054.1	EAW97351.1
		EAW97352.1
		EAW97353.1
		EAW97354.1
		EAW97355.1
		EAW97356.1
mRNA	AF086032.1	None
mRNA	AF458589.1	AAM49717.1
mRNA	AK057712.1	None
mRNA	AK302692.1	BAG63921.1
mRNA	AK314193.1	BAG36872.1
mRNA	AY380574.1	AAQ88438.1
mRNA	BC000812.1	None
mRNA	BC013941.1	AAH13941.1
mRNA	BC040375.1	None
mRNA	BC047898.1	AAH47898.1
mRNA	BC062560.1	None
mRNA	BC092481.1	AAH92481.1
mRNA	BC111752.1	AAI11753.1
mRNA	D87930.1	BAA22378.1
mRNA	DC350703.1	None