PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

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Gene symbol: PDHA1
Gene description: pyruvate dehydrogenase (lipoamide) alpha 1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan

Genomic context

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Location :: chromosome: X

Sequence :: Chromosome: X; NC_006491.3 (19531444..19550050)

See PDHA1 in MapViewer

Chromosome X - NC_006491.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from BioSystems

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Butanoate metabolism, organism-specific biosystem (from KEGG)
Butanoate metabolism, organism-specific biosystem
Butanoate metabolism
Butanoate metabolism, conserved biosystem (from KEGG)
Butanoate metabolism, conserved biosystem
Butanoate metabolism
Citrate cycle (TCA cycle), organism-specific biosystem (from KEGG)
Citrate cycle (TCA cycle), organism-specific biosystemThe citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form ...
Citrate cycle (TCA cycle), conserved biosystem (from KEGG)
Citrate cycle (TCA cycle), conserved biosystemThe citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form ...
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Pyruvate metabolism, organism-specific biosystem (from KEGG)
Pyruvate metabolism, organism-specific biosystem
Pyruvate metabolism
Pyruvate metabolism, conserved biosystem (from KEGG)
Pyruvate metabolism, conserved biosystem
Pyruvate metabolism
Pyruvate oxidation, pyruvate => acetyl-CoA, organism-specific biosystem (from KEGG)
Pyruvate oxidation, pyruvate => acetyl-CoA, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Pyruvate oxidation, pyruvate => acetyl-CoA, conserved biosystem (from KEGG)
Pyruvate oxidation, pyruvate => acetyl-CoA, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism

General gene information

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Markers

PDHA1 (e-PCR)
- UniSTS:498178

RH65815 (e-PCR)
- UniSTS:1029

MAOA (e-PCR), detects polymorphism
- UniSTS:480279

Pdha1 (e-PCR), detects polymorphism
- UniSTS:144154

GDB:192510 (e-PCR)
- UniSTS:99711

GDB:677354 (e-PCR)
- UniSTS:98999

GDB:180536 (e-PCR)
- UniSTS:155108

GDB:438035 (e-PCR)
- UniSTS:99044

Homology

Homologs of the PDHA1 gene: The PDHA1 gene is conserved in human, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and rice.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

General protein information

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Preferred Names: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Names: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; pyruvate dehydrogenase alpha 1

NP_001104283.1

EC 1.2.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110813.1 → NP_001104283.1 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

AB222138

UniProtKB/Swiss-Prot

A5A6L0

Conserved Domains (2) summary

cd02000
Location:64 – 353
Blast Score: 947

TPP_E1_PDC_ADC_BCADC; Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain ...

TIGR03182
Location:58 – 370
Blast Score: 1314

PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 102

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Pan_troglodytes-2.1.4 Primary Assembly

Genomic

NC_006491.3 Reference Pan_troglodytes-2.1.4 Primary Assembly

Range

19531444..19550050

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AACZ03128230.1 (11130..13224)	None
genomic	AACZ03128231.1	None
genomic	AACZ03128232.1	None
genomic	AACZ03128233.1	None
genomic	AF125089.1	AAD23877.1
mRNA	AB222138.1	BAF62383.1
mRNA	GABC01009704.1	JAA01634.1
mRNA	GABD01003249.1	JAA29851.1
mRNA	GABE01008931.1	JAA35808.1
mRNA	GABF01006013.1	JAA16132.1