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MYO1D myosin ID [ Homo sapiens (human) ]

Gene ID: 4642, updated on 12-May-2016
Official Symbol
MYO1Dprovided by HGNC
Official Full Name
myosin IDprovided by HGNC
Primary source
HGNC:HGNC:7598
See related
Ensembl:ENSG00000176658 HPRD:07581; MIM:606539; Vega:OTTHUMG00000179636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
myr4; PPP1R108
Orthologs
Location:
17q11.2
Exon count:
25
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (32492522..32877173, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30819628..31203902, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 11 Neighboring gene uncharacterized LOC105371734 Neighboring gene uncharacterized LOC105371733 Neighboring gene cyclin-dependent kinase 5, regulatory subunit 1 (p35) Neighboring gene uncharacterized LOC101927198 Neighboring gene uncharacterized LOC102724715 Neighboring gene transmembrane protein 98

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study.
NHGRI GWA Catalog
Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns.
NHGRI GWA Catalog
Genome-wide association study of pancreatic cancer in Japanese population.
NHGRI GWA Catalog
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0727

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin-dependent ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular localization ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome to recycling endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
axolemma IEA
Inferred from Electronic Annotation
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
brush border ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
unconventional myosin-Id
Names
myosin-I gamma
protein phosphatase 1, regulatory subunit 108

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303279.1NP_001290208.1  unconventional myosin-Id isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB018270, AC084809, AK127942, BC030602, DB363168
    Consensus CDS
    CCDS76991.1
    UniProtKB/Swiss-Prot
    O94832
    UniProtKB/TrEMBL
    J3QRN6
    Related
    ENSP00000464305, OTTHUMP00000262033, ENST00000579584, OTTHUMT00000447462
    Conserved Domains (3) summary
    smart00242
    Location:4694
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:802954
    Myosin_TH1; Myosin tail
    cd01378
    Location:24682
    MYSc_Myo1; class I myosin, motor domain
  2. NM_001303280.1NP_001290209.1  unconventional myosin-Id isoform 3

    See identical proteins and their annotated locations for NP_001290209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC084809, BC030602
    Consensus CDS
    CCDS76992.1
    UniProtKB/TrEMBL
    J3KRL0
    Related
    ENSP00000462055, OTTHUMP00000262035, ENST00000583621, OTTHUMT00000447473
    Conserved Domains (2) summary
    smart00242
    Location:4433
    MYSc; Myosin. Large ATPases
    cl22853
    Location:24433
    Motor_domain; Myosin and Kinesin motor domain.
  3. NM_015194.2NP_056009.1  unconventional myosin-Id isoform 1

    See identical proteins and their annotated locations for NP_056009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB018270, AC007982, AC084809, BC030602, BC030796
    Consensus CDS
    CCDS32615.1
    UniProtKB/Swiss-Prot
    O94832
    UniProtKB/TrEMBL
    Q8N618
    Related
    ENSP00000324527, OTTHUMP00000262032, ENST00000318217, OTTHUMT00000447457
    Conserved Domains (3) summary
    smart00242
    Location:4694
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:8021005
    Myosin_TH1; Myosin tail
    cd01378
    Location:24682
    MYSc_Myo1; class I myosin, motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    32492522..32877173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_934470.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    30882002..31266960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)