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    Fer1HCH Ferritin 1 heavy chain homologue [ Drosophila melanogaster ]

    Gene ID: 46415, updated on 21-Jan-2012
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    Summary

    Official Symbol
    Fer1HCHprovided by Flybase
    Official Full Name
    Ferritin 1 heavy chain homologueprovided by Flybase
    Primary source
    FLYBASE:FBgn0015222
    Locus tag
    Dmel_CG2216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1HCH; BEST:LD36673; CG2216; Dmel\CG2216; Fer-L; Fer1; FER1; Fer1HC; fer1hch; FER1HCH; FerHCH; HCH; l(3)00451; l(3)j10B4; T21; T9
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    Genomic context

    Location :
    99F2-99F2
    Sequence :
    Chromosome: 3R; NT_033777.2 (26211290..26213851, complement)
    See Fer1HCH in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG18404 gene product from transcript CG18404-RA Neighboring gene headcase Neighboring gene CG34300 gene product from transcript CG34300-RA Neighboring gene Ferritin 2 light chain homologue Neighboring gene CG42740 gene product from transcript CG42740-RA Neighboring gene CG15535 gene product from transcript CG15535-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. Metzendorf C, et al. BMC Dev Biol, 2010 Jun 21. PMID 20565922.
    2. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Rival T, et al. Eur J Neurosci, 2009 Apr. PMID 19519625.
    3. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Metzendorf C, et al. Biochem J, 2009 Jul 15. PMID 19453295.
    4. Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster. Gruenewald C, et al. Free Radic Biol Med, 2009 Jun 15. PMID 19345730.
    5. ER stress protects from retinal degeneration. Mendes CS, et al. EMBO J, 2009 May 6. PMID 19339992.

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Mitoferrin overexpression upregulated Fer1HCH transcription.
      Title: Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:70219 BioGRID:61276 CG10949    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:64022 CG12607    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:62825 CG15071    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:68662 CG32016    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:67420 CG5466    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:64380 CG6683    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:60220 CG7231    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:77783 CheB38a    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:69415 Fer2LCH    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:61299 Fs(2)Ket    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:64301 Hn    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:61352 Mio    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:62001 Obp47b    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:68683 Ppn    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:60212 TwdlE    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:66191 pch2    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:65184 sinah    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:67475 slmb    BioGRID  PubMed Two-hybrid 
    BioGRID:70219 BioGRID:68841 vih    BioGRID  PubMed Two-hybrid 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ferrous iron binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular iron ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular ferritin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular ferritin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    intracellular ferritin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG2216 gene product from transcript CG2216-RA
    Names
    CG2216-PA
    CG2216-PB
    CG2216-PC
    CG2216-PD
    CG2216-PE
    Fer1HCH-PA
    Fer1HCH-PB
    Fer1HCH-PC
    Fer1HCH-PD
    Fer1HCH-PE
    Ferritin-Heavy
    Ferritin-Light
    ferritin
    ferritin 1 heavy chain homolog
    ferritin 1 heavy chain homologue
    ferritin H
    ferritin heavy chain
    ferritin subunit 1
    NP_524873.1
    NP_733358.1
    NP_733359.1
    NP_733360.1
    NP_733361.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      26211290..26213851, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080134.2 → NP_524873.1  ferritin 1 heavy chain homologue, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRU8
      Related
      FBpp0084995, FBtr0085631
      Conserved Domains (2) summary
      cd01056
      Location:39 – 203
      Blast Score: 455
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 – 189
      Blast Score: 235
      Ferritin; Ferritin-like domain

    2. NM_170479.1 → NP_733358.1  ferritin 1 heavy chain homologue, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRU8
      Related
      FBpp0084996, FBtr0085632
      Conserved Domains (2) summary
      cd01056
      Location:39 – 203
      Blast Score: 455
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 – 189
      Blast Score: 235
      Ferritin; Ferritin-like domain

    3. NM_170482.1 → NP_733361.1  ferritin 1 heavy chain homologue, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0T0
      Related
      FBpp0084999, FBtr0085635
      Conserved Domains (1) summary
      cd01056
      Location:39 – 102
      Blast Score: 268
      Euk_Ferritin; eukaryotic ferritins

    4. NM_170481.1 → NP_733360.1  ferritin 1 heavy chain homologue, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRU8
      Related
      FBpp0084998, FBtr0085634
      Conserved Domains (2) summary
      cd01056
      Location:39 – 203
      Blast Score: 455
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 – 189
      Blast Score: 235
      Ferritin; Ferritin-like domain

    5. NM_170480.1 → NP_733359.1  ferritin 1 heavy chain homologue, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRU8
      Related
      FBpp0084997, FBtr0085633
      Conserved Domains (2) summary
      cd01056
      Location:39 – 203
      Blast Score: 455
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 – 189
      Blast Score: 235
      Ferritin; Ferritin-like domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA Y15629.1 CAA75724.1
    mRNA AY061831.1 AAL27642.1
    genomic AE014297.2 AAF57037.1
    mRNA U91524.1 AAB70121.1
    genomic AE014297.2 AAF57036.1
    genomic AE014297.2 AAF57035.1
    genomic AE014297.2 AAF57034.1
    genomic AE014297.2 AAN14227.1
    mRNA BT001419.1 AAN71174.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q7KRU8.1 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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