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MYLK myosin light chain kinase [ Homo sapiens (human) ]

Gene ID: 4638, updated on 22-May-2016
Official Symbol
MYLKprovided by HGNC
Official Full Name
myosin light chain kinaseprovided by HGNC
Primary source
HGNC:HGNC:7590
See related
Ensembl:ENSG00000065534 HPRD:02952; MIM:600922; Vega:OTTHUMG00000141304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRP; AAT7; MLCK; MLCK1; MYLK1; smMLCK; MLCK108; MLCK210; MSTP083
Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q21
Exon count:
34
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (123612296..123884302, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123331143..123603149, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC102723611 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene MYLK antisense RNA 1 Neighboring gene uncharacterized LOC105369194 Neighboring gene MYLK antisense RNA 2 Neighboring gene uncharacterized LOC105374075 Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MYLK that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2016-01-14)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2016-01-14)

ClinGen Genome Curation PagePubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat in combination with morphine activates myosin light chain kinase expression in primary brain micro vascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Endothelin, organism-specific biosystem (from WikiPathways)
    Endothelin, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12216, DKFZp686I10125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
myosin light chain kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aorta smooth muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bleb assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular hypotonic response IDA
Inferred from Direct Assay
more info
PubMed 
mitophagy in response to mitochondrial depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
muscle contraction TAS
Traceable Author Statement
more info
 
positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of wound healing IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
tonic smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
myosin light chain kinase, smooth muscle
Names
kinase-related protein
myosin, light polypeptide kinase
smooth muscle myosin light chain kinase
telokin
NP_444253.3
NP_444254.3
NP_444255.3
NP_444256.3
NP_444259.1
NP_444260.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029111.1 RefSeqGene

    Range
    5001..277007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321309.1NP_001308238.1  myosin light chain kinase, smooth muscle isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC020634, AC117381, AY339601, BC064695, BC113458, BQ006428, DA853780, U48959
    Conserved Domains (8) summary
    cd00096
    Location:464533
    Ig; Immunoglobulin domain
    cd05762
    Location:10621159
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00408
    Location:364
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:12881543
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:11551247
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:16331723
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:12851543
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cl11960
    Location:548633
    Ig; Immunoglobulin domain
  2. NM_053025.3NP_444253.3  myosin light chain kinase, smooth muscle isoform 1

    See identical proteins and their annotated locations for NP_444253.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the full-length transcript and encodes the full-length nonmuscle isoform.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS46896.1
    UniProtKB/Swiss-Prot
    Q15746
    Related
    ENSP00000353452, ENST00000360304
    Conserved Domains (7) summary
    cd00096
    Location:640709
    Ig; Immunoglobulin domain
    cd05762
    Location:12381335
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00220
    Location:14641719
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:13311423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18091899
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14611719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cl11960
    Location:724809
    Ig; Immunoglobulin domain
  3. NM_053026.3NP_444254.3  myosin light chain kinase, smooth muscle isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) does not utilize exon 11, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS43141.1
    UniProtKB/Swiss-Prot
    Q15746
    Related
    ENSP00000320622, OTTHUMP00000180643, ENST00000346322, OTTHUMT00000280601
    Conserved Domains (7) summary
    cd00096
    Location:571640
    Ig; Immunoglobulin domain
    cd05762
    Location:11691266
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00220
    Location:13951650
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:12621354
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:17401830
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:13921650
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cl11960
    Location:655740
    Ig; Immunoglobulin domain
  4. NM_053027.3NP_444255.3  myosin light chain kinase, smooth muscle isoform 3A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3A) does not utilize exon 30, compared to variant 1, resulting in a shorter protein (isoform 3A), compared to isoform 1.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    Consensus CDS
    CCDS3023.1
    UniProtKB/Swiss-Prot
    Q15746
    Related
    ENSP00000352088, ENST00000359169
    Conserved Domains (7) summary
    cd00096
    Location:640709
    Ig; Immunoglobulin domain
    cd05762
    Location:12381335
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00220
    Location:14641694
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:13311423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:17581848
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724809
    Ig; Immunoglobulin domain
    cl21453
    Location:14611668
    PKc_like; Protein Kinases, catalytic domain
  5. NM_053028.3NP_444256.3  myosin light chain kinase, smooth muscle isoform 3B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3B) does not utilize exons 11 and 30, compared to variant 1, resulting in a shorter protein (isoform 3B), compared to isoform 1.
    Source sequence(s)
    AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
    UniProtKB/Swiss-Prot
    Q15746
    Conserved Domains (7) summary
    cd00096
    Location:571640
    Ig; Immunoglobulin domain
    cd05762
    Location:11691266
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00220
    Location:13951625
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:12621354
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:16891779
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:655740
    Ig; Immunoglobulin domain
    cl21453
    Location:13921599
    PKc_like; Protein Kinases, catalytic domain
  6. NM_053031.2NP_444259.1  myosin light chain kinase, smooth muscle isoform 7

    See identical proteins and their annotated locations for NP_444259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and the remainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons.
    Source sequence(s)
    AF096774, AH008116, BM723621, BU678390, CA391924, CA432076
    Consensus CDS
    CCDS58849.1
    UniProtKB/Swiss-Prot
    Q15746
    Related
    ENSP00000463691, OTTHUMP00000260374, ENST00000578202, OTTHUMT00000444083
    Conserved Domains (2) summary
    cd00096
    Location:65135
    Ig; Immunoglobulin domain
    pfam07679
    Location:48138
    I-set; Immunoglobulin I-set domain
  7. NM_053032.2NP_444260.1  myosin light chain kinase, smooth muscle isoform 8

    See identical proteins and their annotated locations for NP_444260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons.
    Source sequence(s)
    AF096773, AH008116, BM723621, BU678390, CA391924, CA432076
    Consensus CDS
    CCDS46897.1
    UniProtKB/Swiss-Prot
    Q15746
    Related
    ENSP00000428967, OTTHUMP00000225212, ENST00000418370, OTTHUMT00000358552
    Conserved Domains (2) summary
    cd00096
    Location:66136
    Ig; Immunoglobulin domain
    pfam07679
    Location:49139
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    123612296..123884302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512862.1XP_011511164.1  

    Conserved Domains (8) summary
    cd00096
    Location:464533
    Ig; Immunoglobulin domain
    cd05762
    Location:10621159
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00408
    Location:364
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:12881543
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:11551247
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:16331723
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:12851543
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cl11960
    Location:548633
    Ig; Immunoglobulin domain
  2. XM_011512861.1XP_011511163.1  

    Conserved Domains (7) summary
    cd00096
    Location:640709
    Ig; Immunoglobulin domain
    cd05762
    Location:12381335
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00220
    Location:14731651
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:13311423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:17411831
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724809
    Ig; Immunoglobulin domain
    cl21453
    Location:14731651
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011512860.1XP_011511162.1  

    UniProtKB/Swiss-Prot
    Q15746
    Conserved Domains (7) summary
    cd00096
    Location:640709
    Ig; Immunoglobulin domain
    cd05762
    Location:12381335
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00220
    Location:14641719
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:13311423
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18081898
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14611719
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cl11960
    Location:724809
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    123294136..123566156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005965.3: Suppressed sequence

    Description
    NM_005965.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_053029.2: Suppressed sequence

    Description
    NM_053029.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_053030.2: Suppressed sequence

    Description
    NM_053030.2: This RefSeq was permanently suppressed because there was insufficient support for the transcript and the CDS was partial.