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MYH10 myosin, heavy chain 10, non-muscle [ Homo sapiens (human) ]

Gene ID: 4628, updated on 24-Aug-2014
Official Symbol
MYH10provided by HGNC
Official Full Name
myosin, heavy chain 10, non-muscleprovided by HGNC
Primary source
HGNC:7568
See related
Ensembl:ENSG00000133026; HPRD:01178; MIM:160776; Vega:OTTHUMG00000108195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMMHCB; NMMHC-IIB
Summary
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
See MYH10 in Epigenomics, MapViewer
Location:
17p13
Exon count:
44
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (8474205..8630770, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8377523..8534094, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 222 Neighboring gene nudE neurodevelopment protein 1-like 1 Neighboring gene uncharacterized LOC102724262 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene ribosomal protein S26 pseudogene 53 Neighboring gene uncharacterized LOC102724287 Neighboring gene coiled-coil domain containing 42

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat The centripetal and lateral movements of the HIV-1 Tat protein transduction domain are linked to the integrity of myosin II-based actin contraction in HeLa cells PubMed
retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
    Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
  • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
    Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC134913, MGC134914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to actin filament binding IMP
Inferred from Mutant Phenotype
more info
 
actin-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to actin-dependent ATPase activity IMP
Inferred from Mutant Phenotype
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microfilament motor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP catabolic process IMP
Inferred from Mutant Phenotype
more info
 
actin filament-based movement IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
 
adult heart development IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cardiac myofibril assembly IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cerebellar Purkinje cell layer development IEA
Inferred from Electronic Annotation
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
fourth ventricle development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
lateral ventricle development IEA
Inferred from Electronic Annotation
more info
 
mitotic cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
nuclear migration IEA
Inferred from Electronic Annotation
more info
 
plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
substrate-dependent cell migration, cell extension IEA
Inferred from Electronic Annotation
more info
 
third ventricle development IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actomyosin IDA
Inferred from Direct Assay
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
myosin II complex IDA
Inferred from Direct Assay
more info
 
myosin II filament IDA
Inferred from Direct Assay
more info
 
myosin complex NAS
Non-traceable Author Statement
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
myosin-10
Names
myosin-10
nonmuscle myosin heavy chain IIB
nonmuscle myosin II heavy chain-B
cellular myosin heavy chain, type B
myosin heavy chain, nonmuscle type B
myosin, heavy polypeptide 10, non-muscle

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256012.1NP_001242941.1  myosin-10 isoform 1

    See proteins identical to NP_001242941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB210026, AB621820, AC011061, AC026130, AK026977, BC000280, CA443268, M69181
    Consensus CDS
    CCDS58515.1
    UniProtKB/TrEMBL
    G1UI33
    UniProtKB/Swiss-Prot
    P35580
    Related
    ENSP00000353590, OTTHUMP00000165799, ENST00000360416, OTTHUMT00000258891
    Conserved Domains (8) summary
    TIGR03495
    Location:18101898
    Blast Score: 108
    phage_LysB; phage lysis regulatory protein, LysB family
    pfam01576
    Location:11041961
    Blast Score: 1556
    Myosin_tail_1; Myosin tail
    COG5134
    Location:13691497
    Blast Score: 91
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd01377
    Location:81813
    Blast Score: 3500
    MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...
    pfam02736
    Location:3375
    Blast Score: 140
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam04012
    Location:9981202
    Blast Score: 93
    PspA_IM30; PspA/IM30 family
    cl19113
    Location:10681201
    Blast Score: 104
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19818
    Location:16761727
    Blast Score: 97
    DUF106; Integral membrane protein DUF106
  2. NM_001256095.1NP_001243024.1  myosin-10 isoform 3

    See proteins identical to NP_001243024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB210026, AK026977, BC144668, BG723653, CA443268, DA737414
    Consensus CDS
    CCDS73984.1
    UniProtKB/Swiss-Prot
    P35580
    Related
    ENSP00000369315, ENST00000379980
    Conserved Domains (8) summary
    TIGR03495
    Location:17881876
    Blast Score: 108
    phage_LysB; phage lysis regulatory protein, LysB family
    pfam01576
    Location:10821939
    Blast Score: 1551
    Myosin_tail_1; Myosin tail
    COG5134
    Location:13471475
    Blast Score: 91
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd01377
    Location:81791
    Blast Score: 3530
    MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...
    pfam02736
    Location:3375
    Blast Score: 140
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam04012
    Location:9761180
    Blast Score: 93
    PspA_IM30; PspA/IM30 family
    cl19113
    Location:10461179
    Blast Score: 104
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19818
    Location:16541705
    Blast Score: 97
    DUF106; Integral membrane protein DUF106
  3. NM_005964.3NP_005955.3  myosin-10 isoform 2

    See proteins identical to NP_005955.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK026977, BC000280, BC117690, BC117691, BG723653, CA443268, DA737414
    Consensus CDS
    CCDS11144.1
    UniProtKB/Swiss-Prot
    P35580
    Related
    ENSP00000269243, OTTHUMP00000135337, ENST00000269243, OTTHUMT00000227001
    Conserved Domains (8) summary
    TIGR03495
    Location:17791867
    Blast Score: 107
    phage_LysB; phage lysis regulatory protein, LysB family
    pfam01576
    Location:10731930
    Blast Score: 1549
    Myosin_tail_1; Myosin tail
    COG5134
    Location:13381466
    Blast Score: 91
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd01377
    Location:81782
    Blast Score: 3525
    MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...
    pfam02736
    Location:3375
    Blast Score: 140
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam04012
    Location:9671171
    Blast Score: 92
    PspA_IM30; PspA/IM30 family
    cl19113
    Location:10371170
    Blast Score: 104
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19818
    Location:16451696
    Blast Score: 96
    DUF106; Integral membrane protein DUF106

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    8474205..8630770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256652.2XP_005256709.1  

    UniProtKB/Swiss-Prot
    P35580
    Conserved Domains (8) summary
    TIGR03495
    Location:18001888
    Blast Score: 108
    phage_LysB; phage lysis regulatory protein, LysB family
    pfam01576
    Location:10941951
    Blast Score: 1555
    Myosin_tail_1; Myosin tail
    COG5134
    Location:13591487
    Blast Score: 91
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd01377
    Location:81803
    Blast Score: 3496
    MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...
    pfam02736
    Location:3375
    Blast Score: 140
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam04012
    Location:9881192
    Blast Score: 93
    PspA_IM30; PspA/IM30 family
    cl19113
    Location:10581191
    Blast Score: 104
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19818
    Location:16661717
    Blast Score: 97
    DUF106; Integral membrane protein DUF106
  2. XM_005256653.2XP_005256710.1  

    Conserved Domains (8) summary
    TIGR03495
    Location:17891877
    Blast Score: 108
    phage_LysB; phage lysis regulatory protein, LysB family
    pfam01576
    Location:10831940
    Blast Score: 1550
    Myosin_tail_1; Myosin tail
    COG5134
    Location:13481476
    Blast Score: 91
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd01377
    Location:81792
    Blast Score: 3529
    MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...
    pfam02736
    Location:3375
    Blast Score: 140
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam04012
    Location:9771181
    Blast Score: 92
    PspA_IM30; PspA/IM30 family
    cl19113
    Location:10471180
    Blast Score: 104
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19818
    Location:16551706
    Blast Score: 97
    DUF106; Integral membrane protein DUF106
  3. XM_005256651.2XP_005256708.1  

    See proteins identical to XP_005256708.1

    UniProtKB/Swiss-Prot
    P35580
    Conserved Domains (8) summary
    TIGR03495
    Location:18101898
    Blast Score: 108
    phage_LysB; phage lysis regulatory protein, LysB family
    pfam01576
    Location:11041961
    Blast Score: 1556
    Myosin_tail_1; Myosin tail
    COG5134
    Location:13691497
    Blast Score: 91
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd01377
    Location:81813
    Blast Score: 3500
    MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...
    pfam02736
    Location:3375
    Blast Score: 140
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam04012
    Location:9981202
    Blast Score: 93
    PspA_IM30; PspA/IM30 family
    cl19113
    Location:10681201
    Blast Score: 104
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19818
    Location:16761727
    Blast Score: 97
    DUF106; Integral membrane protein DUF106

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    8276713..8433166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    8386377..8542853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)