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NUDT12 nudix hydrolase 12 [ Pan troglodytes (chimpanzee) ]

Gene ID: 461977, updated on 29-Mar-2024

Summary

Official Symbol
NUDT12provided by VGNC
Official Full Name
nudix hydrolase 12provided by VGNC
Primary source
VGNC:VGNC:4109
Locus tag
CK820_G0031836
See related
Ensembl:ENSPTRG00000017114
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
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Genomic context

Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 4 NC_072402.2 (101278808..101292740, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 5 NC_072403.1 (101342364..101356297, complement)

Chromosome 4 - NC_072402.2Genomic Context describing neighboring genes Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene macrophage immunometabolism regulator Neighboring gene uncharacterized LOC112209230 Neighboring gene uncharacterized LOC104006502 Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADH pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in NAD catabolic process IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in NADH metabolic process IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in NADP catabolic process IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
peroxisomal NADH pyrophosphatase NUDT12; NAD-capped RNA hydrolase NUDT12
Names
nudix (nucleoside diphosphate linked moiety X)-type motif 12
XP_003310821.1
XP_009447712.1
XP_009447713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    101278808..101292740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003310773.6XP_003310821.1  NAD-capped RNA hydrolase NUDT12 isoform X2

    See identical proteins and their annotated locations for XP_003310821.1

    UniProtKB/TrEMBL
    A0A2J8L7N8, A0A6D2VUP0, H2QRA4
    Related
    ENSPTRP00000029297.3
    Conserved Domains (3) summary
    COG2816
    Location:126455
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:1498
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1443
    ANK; ANK repeat [structural motif]
  2. XM_009449438.5XP_009447713.1  NAD-capped RNA hydrolase NUDT12 isoform X2

    See identical proteins and their annotated locations for XP_009447713.1

    UniProtKB/TrEMBL
    A0A2J8L7N8, A0A6D2VUP0, H2QRA4
    Conserved Domains (3) summary
    COG2816
    Location:126455
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:1498
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1443
    ANK; ANK repeat [structural motif]
  3. XM_009449437.5XP_009447712.1  NAD-capped RNA hydrolase NUDT12 isoform X1

    Conserved Domains (7) summary
    COG2816
    Location:129458
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:17101
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:326459
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:151280
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:282305
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:3489
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1746
    ANK; ANK repeat [structural motif]