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    MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) [ Homo sapiens (human) ]

    Gene ID: 4613, updated on 19-May-2013
    Official Symbol
    MYCNprovided by HGNC
    Official Full Name
    v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)provided by HGNC
    Primary source
    HGNC:7559
    See related
    Ensembl:ENSG00000134323; HPRD:01278; MIM:164840; Vega:OTTHUMG00000039579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NMYC; ODED; MODED; N-myc; bHLHe37
    Summary
    This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008]
    Location :
    2p24.3
    Sequence :
    Chromosome: 2; NC_000002.11 (16080683..16087129)
    See MYCN in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 1 Neighboring gene ribosomal protein, large, P1 pseudogene 5 Neighboring gene MYCN opposite strand/antisense RNA Neighboring gene family with sequence similarity 49, member A Neighboring gene zinc finger, FYVE domain containing 9 pseudogene 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. Corvetta D, et al. J Biol Chem, 2013 Mar 22. PMID 23362253.
    2. MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cells. Gogolin S, et al. Cancer Lett, 2013 Apr 30. PMID 23186832.
    3. Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells. Veschi V, et al. PLoS One, 2012. PMID 23152863.
    4. Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Valentijn LJ, et al. Proc Natl Acad Sci U S A, 2012 Nov 20. PMID 23091029.
    5. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Molenaar JJ, et al. Nat Genet, 2012 Nov. PMID 23042116.

    See all (211) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Both wild-type and gain-of-function mutants in ALK are able to stimulate transcription at the MYCN promoter.
      Title: Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.
    2. Binding of MYCN to the CLU gene induces bivalent epigenetic marks and recruitment of repressive proteins such as histone deacetylases and Polycomb members.
      Title: Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications.
    3. Galectin-3 impairs MYCN-primed and HIPK2-p53-dependent apoptosis in neuroblastoma cells.
      Title: Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.
    4. MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cells.
      Title: MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cells.
    5. LIN28B signaled through repression of the let-7 miRNAs and consequently resulted in elevated MYCN protein expression in neuroblastoma cells
      Title: LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
    6. a functional axis between MYCN and CDKL5 governing both neuron proliferation rate and differentiation.
      Title: CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.
    7. Downstream targets of MYCN by siRNA-mediated silencing MYCN in neuroblastoma cells, were identified.
      Title: Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.
    8. Pathway analyses suggested transcriptomal upregulation of mTOR-related genes by MYCN.
      Title: Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastoma.
    9. a novel Atx transcriptional mechanism involving AP-1 and SP transcription factors
      Title: Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.
    10. MYCN, an oncoprotein in the pathogenesis of high-risk neuroblastomas, is able to counteract the death-inducing effect of BMI1 knockdown by activating CCNE1 transcription
      Title: Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.
    Submit: New GeneRIF Correction See all (173)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005369.2 NC_000011.8 SLC1A2    BIND  PubMed N-Myc interacts with the EAAT2 promoter. 
    P04198 P68400 CSNK2A1    HPRD  PubMed  
    P04198 P19784 CSNK2A2    HPRD  PubMed  
    P04198 P61244 MAX    HPRD  PubMed  
    P04198 Q05195 MXD1    HPRD  PubMed  
    P04198 Q13287 NMI    HPRD  PubMed  
    P04198 Q8IY57 YAF2    HPRD  PubMed  
    BioGRID:110698 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110698 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110698 BioGRID:107838 CSNK1E    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:110698 BioGRID:107841 CSNK2A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:110698 BioGRID:120581 FBXW7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110698 BioGRID:109127 GRK5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110698 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110698 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110698 BioGRID:110870 NGFR    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:110698 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:110698 BioGRID:114523 PIAS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110698 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110698 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110698 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110698 BioGRID:113761 YEATS4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110698 BioGRID:113503 ZBTB17    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    N-myc proto-oncogene protein
    Names
    N-myc proto-oncogene protein
    pp65/67
    oncogene NMYC
    neuroblastoma MYC oncogene
    class E basic helix-loop-helix protein 37
    neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
    v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007457.1 RefSeqGene

      Range
      5001..11447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005378.4 → NP_005369.2  N-myc proto-oncogene protein

      Status: REVIEWED

      Source sequence(s)
      AC010145, AI962624, BT007384, BU167361
      Consensus CDS
      CCDS1687.1
      UniProtKB/Swiss-Prot
      P04198
      UniProtKB/TrEMBL
      Q53XS5
      Related
      ENSP00000281043, OTTHUMP00000037565, ENST00000281043, OTTHUMT00000095469
      Conserved Domains (2) summary
      cd00083
      Location:386 – 432
      Blast Score: 147
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:11 – 201
      Blast Score: 469
      Myc_N; Myc amino-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p10 Primary Assembly

      Range
      16080683..16087129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      15934021..15938396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018913.1 Alternate CHM1_1.0

      Range
      16048750..16055197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01015687.1 None
    genomic AC010145.10 AAY14952.1
    genomic AJ242956.1 CAB44703.1
    genomic AMYH01010134.1 (259350..261258) None
    genomic AMYH01010135.1 None
    genomic CH471053.2 EAX00885.1
      EAX00886.1
      EAX00887.1
      EAX00888.1
    genomic HC084228.1 CBI12210.1
    genomic JB171962.1 CCW44112.1
    genomic M13228.1 AAA36370.1
    genomic M13241.1 AAA36371.1
    genomic M18090.1 AAA59885.1
    genomic X02363.1 CAB37871.1
    genomic X03294.1 CAA27037.1
    genomic X03295.1 CAA27038.1
    genomic Y00664.1 CAA68677.1
      CAA68678.1
    mRNA AF320053.1 AAG40001.1
    mRNA AI962624.1 None
    mRNA AK298225.1 BAG60495.1
    mRNA AK299495.1 BAG61453.1
    mRNA BC002712.2 AAH02712.1
    mRNA BT007384.1 AAP36048.1
    mRNA BU167361.1 None
    mRNA M55330.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04198.2 GenPept UniProtKB/Swiss-Prot:P04198

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
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        Link to related EST entry
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        Full text in PubMedCentral identified from shared sequence links
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      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
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        Citations in PubMed identified from shared sequence and PMC links.
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        Link to Protein RefSeqs
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