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MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog [ Homo sapiens (human) ]

Gene ID: 4610, updated on 26-May-2016
Official Symbol
MYCLprovided by HGNC
Official Full Name
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homologprovided by HGNC
Primary source
HGNC:HGNC:7555
See related
Ensembl:ENSG00000116990 HPRD:01279; MIM:164850; Vega:OTTHUMG00000009243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMYC; L-Myc; MYCL1; bHLHe38
Orthologs
Location:
1p34.2
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (39895424..39902015, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40361096..40367687, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378667 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene uncharacterized LOC105378668 Neighboring gene major facilitator superfamily domain containing 2A Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene uncharacterized LOC105378669 Neighboring gene uncharacterized LOC105378670

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein L-Myc
Names
class E basic helix-loop-helix protein 38
l-myc-1 proto-oncogene
myc-related gene from lung cancer
protein L-Myc-1
v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033081.2NP_001028253.1  protein L-Myc isoform 1

    See identical proteins and their annotated locations for NP_001028253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI144219, AL033527
    Consensus CDS
    CCDS30682.1
    UniProtKB/Swiss-Prot
    P12524
    Related
    ENSP00000361903, OTTHUMP00000179082, ENST00000372816, OTTHUMT00000277004
    Conserved Domains (2) summary
    cd00083
    Location:279333
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:2220
    Myc_N; Myc amino-terminal region
  2. NM_001033082.2NP_001028254.2  protein L-Myc isoform 3

    See identical proteins and their annotated locations for NP_001028254.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' region and uses an alternate, upstream start codon, compared to variant 1. It encodes isoform 3, which is longer than isoform 1.
    Source sequence(s)
    AI144219, AK296078, AL033527
    Consensus CDS
    CCDS53300.1
    UniProtKB/Swiss-Prot
    P12524
    Related
    ENSP00000380494, OTTHUMP00000010829, ENST00000397332, OTTHUMT00000025624
    Conserved Domains (2) summary
    cd00083
    Location:309363
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:26250
    Myc_N; Myc amino-terminal region
  3. NM_005376.4NP_005367.2  protein L-Myc isoform 2

    See identical proteins and their annotated locations for NP_005367.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1. The resulting isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL033527, BC011864, BX101968
    Consensus CDS
    CCDS44117.2
    UniProtKB/Swiss-Prot
    P12524
    Related
    ENSP00000361902, OTTHUMP00000010830, ENST00000372815, OTTHUMT00000025625
    Conserved Domains (1) summary
    pfam01056
    Location:26233
    Myc_N; Myc amino-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    39895424..39902015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    40476747..40483338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)