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    MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) [ Homo sapiens ]

    Gene ID: 4610, updated on 5-Feb-2012
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    Summary

    Official Symbol
    MYCL1provided by HGNC
    Official Full Name
    v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)provided by HGNC
    Primary source
    HGNC:7555
    Locus tag
    RP1-118J21.4
    See related
    Ensembl:ENSG00000116990; HPRD:01279; MIM:164850; Vega:OTTHUMG00000009243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMYC; MYCL; bHLHe38
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    Genomic context

    Location :
    1p34.2
    Sequence :
    Chromosome: 1; NC_000001.10 (40361096..40367687, complement)
    See MYCL1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287437 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene major facilitator superfamily domain containing 2A Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene CAP, adenylate cyclase-associated protein 1 (yeast)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer. Xiong F, et al. Cancer Res, 2011 Aug 1. PMID 21676885.
    2. Association of a MYCL1 single nucleotide polymorphism, rs3134613, with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer in a southeast Chinese population. Chen SQ, et al. DNA Cell Biol, 2010 Dec. PMID 20874233.
    3. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. Bhatti P, et al. Radiat Res, 2010 Feb. PMID 20095854.
    4. Cell proliferation-related genetic polymorphisms and gastric cancer risk: systematic review and meta-analysis. Gao L, et al. Eur J Hum Genet, 2009 Dec. PMID 19536170.
    5. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. Paulson KG, et al. J Invest Dermatol, 2009 Jun. PMID 19020549.

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MYCL1 is the target of hsa-miR-1827. A rs3134615 G>T SNP in the 3'-UTR altered regulation of MYCL1 expression. This SNP was associated with increased susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827.
      Title: Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer.
    2. The results demonstrate that MYCL1 rs3134613 is associated with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer.
      Title: Association of a MYCL1 single nucleotide polymorphism, rs3134613, with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer in a southeast Chinese population.
    3. L-Myc may have a role in Merkel cell carcinoma pathogenesis
      Title: Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc.
    4. L-myc gene polymorphism may have a role in risk of thyroid cancer
      Title: L-myc gene polymorphism and risk of thyroid cancer.
    5. The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
      Title: L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers.
    6. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Cell proliferation-related genetic polymorphisms and gastric cancer risk: systematic review and meta-analysis.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers.
    8. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.
    9. Colorectal tumor patients whose tumors exhibited loss of heterozygosity at MYCL1 at chromosome 1p34 were likely to have a poor prognosis.
      Title: Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer.
    10. Allelic deletions of L-myc in urine from bladder cancer patients
      Title: Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ.
    Submit: New GeneRIF Correction See all (14)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P12524 P61244 MAX    HPRD  PubMed  
    P12524 Q05195 MXD1    HPRD  PubMed  
    BioGRID:110695 BioGRID:110319 MAX    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    protein L-Myc-1
    Names
    protein L-Myc-1
    l-myc-1 proto-oncogene
    myc-related gene from lung cancer
    class E basic helix-loop-helix protein 38
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033081.2 → NP_001028253.1  protein L-Myc-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AI144219, AL033527
      Consensus CDS
      CCDS30682.1
      UniProtKB/Swiss-Prot
      P12524
      Related
      ENSP00000361903, OTTHUMP00000179082, ENST00000372816, OTTHUMT00000277004
      Conserved Domains (2) summary
      cd00083
      Location:279 – 333
      Blast Score: 157
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:2 – 216
      Blast Score: 288
      Myc_N; Myc amino-terminal region

    2. NM_001033082.2 → NP_001028254.2  protein L-Myc-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' region and uses an alternate, upstream start codon, compared to variant 1. It encodes isoform 3, which is longer than isoform 1.
      Source sequence(s)
      AI144219, AK296078, AL033527
      Consensus CDS
      CCDS53300.1
      UniProtKB/TrEMBL
      B4DJH2
      UniProtKB/Swiss-Prot
      P12524
      Related
      ENSP00000380494, OTTHUMP00000010829, ENST00000397332, OTTHUMT00000025624
      Conserved Domains (2) summary
      cd00083
      Location:309 – 363
      Blast Score: 161
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:26 – 246
      Blast Score: 300
      Myc_N; Myc amino-terminal region

    3. NM_005376.4 → NP_005367.2  protein L-Myc-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences compared to variant 1. The resulting isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AL033527, BC011864, BX101968
      Consensus CDS
      CCDS44117.2
      UniProtKB/Swiss-Prot
      P12524
      Related
      ENSP00000361902, OTTHUMP00000010830, ENST00000372815, OTTHUMT00000025625
      Conserved Domains (1) summary
      pfam01056
      Location:26 – 233
      Blast Score: 212
      Myc_N; Myc amino-terminal region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      40361096..40367687, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      38479732..38486323, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL033527.26 CAB75682.1
      CAI19407.1
      CAI19408.1
    genomic AY191718.1 AAO38672.1
    genomic CH471059.2 EAX07250.1
      EAX07251.1
    genomic HC084230.1 CBI12211.1
    genomic M19720.1 AAA59878.1
      AAA59879.1
    genomic X07262.1 CAA30248.1
    genomic X07263.1 CAA30249.1
    mRNA AI144219.1 None
    mRNA AK296078.1 BAG58834.1
    mRNA AK296838.1 BAG59407.1
    mRNA BC011864.2 AAH11864.1
    mRNA BC030694.1 None
    mRNA BM967204.1 None
    mRNA BX101968.1 None
    other-genetic EU446637.1 ABZ92166.1
    other-genetic EU832700.1 ACE87032.1
    other-genetic JF432838.1 ADZ16055.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P12524.2 GenPept UniProtKB/Swiss-Prot:P12524
    Q86YL9 GenPept UniProtKB/TrEMBL:Q86YL9
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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