MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 [Homo sapiens] - Gene

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Summary

Official Symbol: MYBL2provided by HGNC
Official Full Name: v-myb myeloblastosis viral oncogene homolog (avian)-like 2provided by HGNC
Primary source: HGNC:7548
See related: Ensembl:ENSG00000101057; HPRD:03247; MIM:601415; Vega:OTTHUMG00000033062
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BMYB; B-MYB; MGC15600
Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q13.1

Sequence :: Chromosome: 20; NC_000020.10 (42295709..42345122)

See MYBL2 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.
Title: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
Owing to the role of B-Myb and E2F1 transcription factors in controlling cell-cycle progression of leukemic cells, the downregulation of these oncogenes by miR-34a suggests the usefulness of therapeutic approaches aimed to modulate the levels of miR-34a.
Title: miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells.
study concludes that MYCN and B-MYB are engaged in a reciprocal regulatory loop whose pharmacological targeting could be beneficial to patients with the aggressive forms of cancer in which MYCN is amplified
Title: Addiction of MYCN amplified tumours to B-MYB underscores a reciprocal regulatory loop.
MYBL2 activation is crucial for human HCC progression. In particular, our data indicate that MYBL2-LIN9 complex integrity contributes to survival of DNA damaged p53(-/-) cells.
Title: Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53.
B-MYB acts as a positive regulator of STRAP
Title: B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction.
B-MYB represses p16(INK4alpha)by binding to a MYB-binding site within the promoter region.
Title: B-MYB delays cell aging by repressing p16 (INK4α) transcription.
miR-29 and miR-30 regulate B-Myb expression by binding to its 3'UTR; these microRNAs play an important role in Rb-driven cellular senescence
Title: miR-29 and miR-30 regulate B-Myb expression during cellular senescence.
Data show that that ANCCA is crucial for proliferation and survival of triple-negative/basal-like cancer cells and that it controls the expression of B-Myb and histone methyltransferase EZH2.
Title: ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.
These data suggest that Mybl2 plays a subtle but key role in linking specific aspects of cell-cycle progression with generation of signals for differentiation.
Title: MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

Submit: New GeneRIF Correction See all (30)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000020.9	NP_005216.1	E2F1	BIND	PubMed	E2F1 interacts with the B-myb promoter region.
NC_000020.9	NP_004082.1	E2F2	BIND	PubMed	E2F2 interacts with the B-myb promoter region.
NC_000020.9	NP_001940.1	E2F3	BIND	PubMed	E2F3 interacts with the B-myb promoter region.
NC_000020.9	NP_001941.2	E2F4	BIND	PubMed	E2F4 interacts with the B-myb promoter region.
NC_000020.9	NP_005602.2	RBL2	BIND	PubMed	p130 interacts with the B-myb promoter region.
NP_002457.1	NP_003585.3	TTF2	BIND	PubMed	HuF2 interacts with B-myb.
P10244	P78396	CCNA1	HPRD	PubMed
P10244	P20248	CCNA2	HPRD	PubMed
P10244	P24385	CCND1	HPRD	PubMed
P10244	P24864	CCNE1	HPRD	PubMed
P10244	P49427	CDC34	HPRD	PubMed
P10244	P24941	CDK2	HPRD	PubMed
P10244	P50750	CDK9	HPRD	PubMed
P10244	Q92793	CREBBP	HPRD	PubMed
P10244	Q09472	EP300	HPRD	PubMed
P10244	Q5TKA1	LIN9	HPRD	PubMed
P10244	P10244	MYBL2	HPRD	PubMed
P10244	O75376	NCOR1	HPRD	PubMed
P10244	Q9Y618	NCOR2	HPRD	PubMed
P10244	P09874	PARP1	HPRD	PubMed
P10244	P28749	RBL1	HPRD	PubMed
P10244	Q13309	SKP2	HPRD	PubMed
P10244	Q7KZF4	SND1	HPRD	PubMed
P10244	Q9UNY4	TTF2	HPRD	PubMed
P10244	Ubiquitin B	UBB	HPRD	PubMed
P10244	Q969S3	ZNF622	HPRD	PubMed
BioGRID:110690	BioGRID:114417	CCNA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110690	BioGRID:107343	CCNT1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:110690	BioGRID:107452	CDK2	BioGRID	PubMed	Biochemical Activity
BioGRID:110690	BioGRID:107459	CDK9	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex
BioGRID:110690	BioGRID:107462	CDKN1C	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110690	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement
BioGRID:110690	BioGRID:108201	E2F1	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:108203	E2F3	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110690	BioGRID:118815	HIPK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110690	BioGRID:121008	LIN37	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110690	BioGRID:124874	LIN52	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110690	BioGRID:126328	LIN54	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110690	BioGRID:130420	LIN9	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110690	BioGRID:113852	LZTR1	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:231129	Lin54	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110690	BioGRID:123565	MAP1LC3B	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:110690	MYBL2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110690	BioGRID:119685	NLK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110690	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110690	BioGRID:111868	RBL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110690	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110690	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110690	BioGRID:124626	TRIM15	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:128736	ZBTB9	BioGRID	PubMed	Two-hybrid
BioGRID:110690	BioGRID:124717	ZNF622	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
mitotic cell cycle	TAS Traceable Author Statement more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: myb-related protein B

Names: myb-related protein B; myb-like protein 2; v-myb avian myeloblastosis viral oncogene homolog-like 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002466.2 → NP_002457.1 myb-related protein B

Status: REVIEWED

Source sequence(s)

BC007585, BU178833

Consensus CDS

CCDS13322.1

UniProtKB/Swiss-Prot

P10244

Related

ENSP00000217026, OTTHUMP00000031719, ENST00000217026, OTTHUMT00000080408

Conserved Domains (3) summary

cd00167
Location:85 – 129
Blast Score: 163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

smart00717
Location:83 – 131
Blast Score: 185

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:451 – 605
Blast Score: 519

Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

42295709..42345122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

39031016..39080474

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL121886.22	CAC08392.1
genomic	CH471077.2	EAW75951.1
genomic	X82032.1	CAA57552.1
mRNA	AK223482.1	BAD97202.1
mRNA	AK303249.1	BAH13925.1
mRNA	AK314791.1	BAG37322.1
mRNA	BC007585.1	AAH07585.1
mRNA	BC053555.1	AAH53555.1
mRNA	BU178833.1	None
mRNA	BX647151.1	None
mRNA	X13293.1	CAA31655.1
other-genetic	DQ893522.2	ABM84448.1
other-genetic	DQ895945.2	ABM86871.1