MYB v-myb myeloblastosis viral oncogene homolog (avian) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: MYBprovided by HGNC
Official Full Name: v-myb myeloblastosis viral oncogene homolog (avian)provided by HGNC
Primary source: HGNC:7545
Locus tag: RP1-32B1.1
See related: Ensembl:ENSG00000118513; HPRD:01810; MIM:189990; Vega:OTTHUMG00000015629
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: efg; Cmyb; c-myb; c-myb_CDS
Summary: This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Genomic context

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Location :: 6q22-q23

Sequence :: Chromosome: 6; NC_000006.11 (135502453..135540311)

See MYB in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transgenic K562 cells have distinct gene expression profiles both in steady state and during terminal erythroid differentiation, with GATA1s expression characterised by lack of repression of MYB, CCND2 and SKI.
Title: The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells.
Fbxw5 enhances sumoylation of nuclear c-Myb.
Title: Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation.
These results unravel a critical role of c-Myb in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
Title: c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin.
c-Myb inhibition decreased cell proliferation, increased the number of cells in G(0) /G(1) phase of the cell cycle, increased the sensitivity of pre-B-ALL cells to cytotoxic agents, & delayed disease onset in a mouse model of leukemia.
Title: Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis.
These studies show the mutual importance of c-Myb and the GR in controlling survival of pre-B acute lymphoblastic leukemia cells.
Title: c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute lymphoblastic leukemia cells.
Studies indicate that single nucleotide polymorphisms (SNPs) in regions of BCL11A and HBS1L-MYB intergenic polymorphism are the major modifiers of HbF in African Americans.
Title: Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.
study concludes conclude that: t(6;9) results in complex genetic and molecular alterations in adenoid cystic carcinoma (ACC); MYB-NFIB gene fusion may not always be associated with chimeric transcript formation; noncanonical MYB-NFIB gene fusions occur in a subset of tumors; high MYB expression correlates with worse patient survival
Title: Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome.
Explored copy number alterations rearrangements in adenoid cystic carcinoma. 86% of the tumors expressed MYB-NFIB fusion transcripts and 97% overexpressed MYB mRNA.
Title: Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.
study provides first experimental evidence for a functional role of Myb in growth and malignant behavior of prostate cancer cells and suggest a novel mechanism for castration resistance
Title: Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance.
TGFbeta-induced c-Myb expression enhances invasion and aggressiveness of breast cancer cells.
Title: TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells.

Submit: New GeneRIF Correction See all (100)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.

A genome-wide association study of red blood cell traits using the electronic medical record.

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005366.2	NP_001420.2	EP300	BIND	PubMed	c-Myb interacts with p300.
P10242	P17676	CEBPB	HPRD	PubMed
P10242	Q15744	CEBPE	HPRD	PubMed
P10242	Q92793	CREBBP	HPRD	PubMed
P10242	P68400	CSNK2A1	HPRD	PubMed
P10242	Q09472	EP300	HPRD	PubMed
P10242	Q9H2X6	HIPK2	HPRD	PubMed
P10242	O75444	MAF	HPRD	PubMed
P10242	P28482	MAPK1	HPRD	PubMed
P10242	Q9BQG0	MYBBP1A	HPRD	PubMed
P10242	P19338	NCL	HPRD	PubMed
P10242	Q9UBE8	NLK	HPRD	PubMed
P10242	Q02548	PAX5	HPRD	PubMed
P10242	P29590	PML	HPRD	PubMed
P10242	RQCD1	RQCD1	HPRD	PubMed
P10242	Q7KZF4	SND1	HPRD	PubMed
P10242	Q9UNY4	TTF2	HPRD	PubMed
P10242	P63279	UBE2I	HPRD	PubMed
P10242	Q15911	ZFHX3	HPRD	PubMed
BioGRID:110687	BioGRID:114528	ASH2L	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:107336	CCND3	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:107480	CEBPB	BioGRID	PubMed	Co-crystal Structure
BioGRID:110687	BioGRID:107482	CEBPE	BioGRID	PubMed	Reconstituted Complex
BioGRID:110687	BioGRID:107532	CHD3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex
BioGRID:110687	BioGRID:114029	CUL4A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:108009	DDB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:110687	BioGRID:117521	ERC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:119967	FBXW5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:120581	FBXW7	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110687	BioGRID:206088	Fbxw7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:108895	GATA3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:118815	HIPK2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110687	BioGRID:109376	HLF	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:114375	KAT2B	BioGRID	PubMed	Co-localization
BioGRID:110687	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:110443	KMT2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:119354	LEF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:110269	MAF	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110687	BioGRID:110384	MEN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:119726	MYOZ2	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:110771	NCL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:119685	NLK	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:110687	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:111113	PAX5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:114124	PIAS1	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:111384	PML	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:127472	PPM1K	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:111864	RBBP5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:115301	RBX1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110687	BioGRID:112044	RPL4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:112388	SKI	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:112479	SMARCA2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110687	BioGRID:117974	SND1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110687	BioGRID:112555	SP100	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:112653	STAT5A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:113041	TRAF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110687	BioGRID:114036	TTF2	BioGRID	PubMed	Two-hybrid
BioGRID:110687	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110687	BioGRID:113177	UBE2I	BioGRID	PubMed	Biochemical Activity; Two-hybrid
BioGRID:110687	BioGRID:116272	WDR5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110687	BioGRID:115989	ZMYND11	BioGRID	PubMed	Reconstituted Complex; Two-hybrid

Pathways from BioSystems

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C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
C-MYB transcription factor network, organism-specific biosystem
C-MYB transcription factor network
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
IL2 signaling events mediated by PI3K, organism-specific biosystem
IL2 signaling events mediated by PI3K
IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL4-mediated signaling events, organism-specific biosystem
IL4-mediated signaling events
Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
Notch-mediated HES/HEY network, organism-specific biosystem
Notch-mediated HES/HEY network
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...

General gene information

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Markers

MYB_951 (e-PCR)
- UniSTS:277516

MYB_V226 (e-PCR)
- UniSTS:277516

D6S1837 (e-PCR)
- UniSTS:44817

RH71005 (e-PCR)
- UniSTS:42784

D6S1431 (e-PCR)
- UniSTS:26919

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

PMC20354P3 (e-PCR)
- UniSTS:271936

SHGC-82387 (e-PCR)
- UniSTS:104534

SHGC-106007 (e-PCR)
- UniSTS:169580

D15S1477 (e-PCR)
- UniSTS:474482

RH18093 (e-PCR)
- UniSTS:48765

PMC140821P4 (e-PCR)
- UniSTS:270978

D11Bir11 (e-PCR), detects polymorphism
- UniSTS:141709

D11Bir7 (e-PCR), detects polymorphism
- UniSTS:141711

Homology

Homologs of the MYB gene: The MYB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
chromatin binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell differentiation	IEA Inferred from Electronic Annotation more info
G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
calcium ion transport	IEA Inferred from Electronic Annotation more info
chromatin remodeling	IMP Inferred from Mutant Phenotype more info
embryonic digestive tract development	IEA Inferred from Electronic Annotation more info
homeostasis of number of cells	IEA Inferred from Electronic Annotation more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
positive regulation of T-helper cell differentiation	IMP Inferred from Mutant Phenotype more info
positive regulation of histone H3-K4 methylation	IMP Inferred from Mutant Phenotype more info
positive regulation of histone H3-K9 methylation	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
thymus development	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nuclear matrix	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcriptional activator Myb

Names: transcriptional activator Myb; c-myb8B_CDS; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; proto-oncogene c-Myb; c-myb protein (140 AA)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012330.1 RefSeqGene

Range

5001..42859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130172.1 → NP_001123644.1 transcriptional activator Myb isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal segment and an exon in the coding region, as compared to variant 1. The reading frame is not affected, so the resulting isoform (3) lacks two internal segments, as compared to isoform 1.

Source sequence(s)

AJ606320, D25774

Consensus CDS

CCDS47482.1

UniProtKB/Swiss-Prot

P10242

Related

ENSP00000410825, OTTHUMP00000234321, ENST00000442647, OTTHUMT00000391709

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 162

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 146

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 183

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:399 – 564
Blast Score: 640

Cmyb_C; C-myb, C-terminal
NM_001130173.1 → NP_001123645.1 transcriptional activator Myb isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AJ606319, D25774

Consensus CDS

CCDS47481.1

UniProtKB/Swiss-Prot

P10242

Related

ENSP00000339992, OTTHUMP00000017259, ENST00000341911, OTTHUMT00000042348

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 166

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 147

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 186

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:518 – 688
Blast Score: 658

Cmyb_C; C-myb, C-terminal
NM_001161656.1 → NP_001155128.1 transcriptional activator Myb isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.

Source sequence(s)

AL023693

Consensus CDS

CCDS55058.1

UniProtKB/Swiss-Prot

P10242

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 166

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 147

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 186

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:515 – 685
Blast Score: 659

Cmyb_C; C-myb, C-terminal
NM_001161657.1 → NP_001155129.1 transcriptional activator Myb isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.

Source sequence(s)

AL023693

Consensus CDS

CCDS55061.1

UniProtKB/TrEMBL

E9PRS2

Related

ENSP00000435938, OTTHUMP00000234322, ENST00000525369, OTTHUMT00000391710

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 159

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 144

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 180

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:317 – 482
Blast Score: 641

Cmyb_C; C-myb, C-terminal
NM_001161658.1 → NP_001155130.1 transcriptional activator Myb isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 6) compared to isoform 1.

Source sequence(s)

AL023693

Consensus CDS

CCDS55059.1

UniProtKB/TrEMBL

E9PNA4

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 166

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 148

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 186

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:502 – 672
Blast Score: 658

Cmyb_C; C-myb, C-terminal
NM_001161659.1 → NP_001155131.1 transcriptional activator Myb isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 7, which is shorter than isoform 1.

Source sequence(s)

AL023693

Consensus CDS

CCDS55060.1

UniProtKB/TrEMBL

E9PLZ5

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 162

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 145

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 182

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:402 – 594
Blast Score: 520

Cmyb_C; C-myb, C-terminal
NM_001161660.1 → NP_001155132.1 transcriptional activator Myb isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 8, which is shorter than isoform 1.

Source sequence(s)

AL023693

Consensus CDS

CCDS55062.1

UniProtKB/TrEMBL

E9PI07

Conserved Domains (3) summary

cd00167
Location:94 – 138
Blast Score: 163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

smart00717
Location:92 – 140
Blast Score: 183

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:367 – 532
Blast Score: 641

Cmyb_C; C-myb, C-terminal
NM_005375.2 → NP_005366.2 transcriptional activator Myb isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

BC035996, BC064955, X52125, X52126

Consensus CDS

CCDS5174.1

UniProtKB/Swiss-Prot

P10242

UniProtKB/TrEMBL

Q14025

UniProtKB/TrEMBL

Q708E9

Related

ENSP00000356788, OTTHUMP00000017258, ENST00000367814, OTTHUMT00000042347

Conserved Domains (4) summary

cd00167
Location:94 – 138
Blast Score: 163

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam07988
Location:266 – 313
Blast Score: 146

LMSTEN; LMSTEN motif

smart00717
Location:92 – 140
Blast Score: 183

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam09316
Location:402 – 567
Blast Score: 639

Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p10 Primary Assembly

Range

135502453..135540311

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

133066684..133104587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018917.1 Alternate CHM1_1.0

Range

135502834..135540692

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01025842.1 (13350..34108)	None
genomic	ABBA01025843.1	None
genomic	AL023693.25 (68629..106487)	None
genomic	AMYH01016693.1 (138..37996)	None
genomic	CH471051.2	EAW47967.1
		EAW47968.1
		EAW47969.1
		EAW47970.1
		EAW47971.1
		EAW47972.1
		EAW47973.1
		EAW47974.1
		EAW47975.1
		EAW47976.1
		EAW47977.1
		EAW47978.1
genomic	FB659824.1	CAS01767.1
genomic	GU324928.1	ADL14499.1
genomic	HH970061.1	CBX51725.1
genomic	M95584.1	AAA72118.1
genomic	U22376.1	AAB49034.1
		AAB49035.1
		AAB49036.1
		AAB49037.1
		AAB49038.1
		AAB49039.1
mRNA	AF104863.1	AAC96326.1
mRNA	AJ606317.1	CAE55168.1
mRNA	AJ606318.1	CAE55169.1
mRNA	AJ606319.1	CAE55170.1
mRNA	AJ606320.1	CAE55171.1
mRNA	AJ606321.1	CAE55172.1
mRNA	AJ606322.1	CAE55173.1
mRNA	AJ606323.1	CAE55174.1
mRNA	AJ606324.1	CAE55175.1
mRNA	AJ616235.1	CAE82649.1
mRNA	AJ616791.1	CAF04477.1
		CAF04478.1
		CAF04479.1
		CAF04480.1
		CAF04481.1
		CAF04482.1
		CAF04483.1
		CAF04484.1
		CAF04485.1
mRNA	AJ616792.1	None
mRNA	AJ616793.1	None
mRNA	AJ616794.1	None
mRNA	AJ616795.1	None
mRNA	AJ616796.4	None
mRNA	AJ616797.1	None
mRNA	AJ616801.1	None
mRNA	AJ616802.1	None
mRNA	AJ616805.1	None
mRNA	AY787443.1	None
mRNA	AY787444.1	None
mRNA	AY787445.1	None
mRNA	AY787446.1	None
mRNA	AY787447.1	None
mRNA	AY787448.1	None
mRNA	AY787449.1	None
mRNA	AY787450.1	None
mRNA	AY787451.1	None
mRNA	AY787452.1	None
mRNA	AY787453.1	None
mRNA	AY787454.1	None
mRNA	AY787455.1	None
mRNA	AY787456.1	None
mRNA	AY787457.1	None
mRNA	AY787458.1	None
mRNA	AY787459.1	None
mRNA	AY787460.1	None
mRNA	AY787461.1	None
mRNA	AY787462.1	None
mRNA	AY787463.1	None
mRNA	AY787464.1	None
mRNA	AY787465.1	None
mRNA	AY787466.1	None
mRNA	AY787467.1	None
mRNA	AY787468.1	None
mRNA	AY787469.1	None
mRNA	AY787470.1	None
mRNA	AY787471.1	None
mRNA	AY787472.1	None
mRNA	AY787473.1	None
mRNA	AY787474.1	None
mRNA	AY787475.1	None
mRNA	BC035996.1	None
mRNA	BC064955.1	AAH64955.1
mRNA	D25774.1	None
mRNA	M13665.1	AAA52030.1
mRNA	M13666.1	AAA52031.1
mRNA	M15024.1	AAA52032.1
mRNA	X17469.1	CAA35503.1
mRNA	X52125.1	CAA36371.1
mRNA	X52126.1	CAA36372.1