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    MYB v-myb myeloblastosis viral oncogene homolog (avian) [ Homo sapiens ]

    Gene ID: 4602, updated on 11-May-2012

    Summary

    Official Symbol
    MYBprovided by HGNC
    Official Full Name
    v-myb myeloblastosis viral oncogene homolog (avian)provided by HGNC
    Primary source
    HGNC:7545
    Locus tag
    RP1-32B1.1
    See related
    Ensembl:ENSG00000118513; HPRD:01810; MIM:189990; Vega:OTTHUMG00000015629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    efg; Cmyb; c-myb; c-myb_CDS
    Summary
    This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

    Genomic context

    Location :
    6q22-q23
    Sequence :
    Chromosome: 6; NC_000006.11 (135502453..135540311)

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene HBS1-like (S. cerevisiae) Neighboring gene microRNA 3662 Neighboring gene microRNA 548a-2 Neighboring gene beta-transducin repeat containing pseudogene Neighboring gene Abelson helper integration site 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005366.2 NP_001420.2 EP300    BIND  PubMed c-Myb interacts with p300. 
    P10242 P17676 CEBPB    HPRD  PubMed  
    P10242 Q15744 CEBPE    HPRD  PubMed  
    P10242 Q92793 CREBBP    HPRD  PubMed  
    P10242 P68400 CSNK2A1    HPRD  PubMed  
    P10242 Q09472 EP300    HPRD  PubMed  
    P10242 Q9H2X6 HIPK2    HPRD  PubMed  
    P10242 O75444 MAF    HPRD  PubMed  
    P10242 P28482 MAPK1    HPRD  PubMed  
    P10242 Q9BQG0 MYBBP1A    HPRD  PubMed  
    P10242 P19338 NCL    HPRD  PubMed  
    P10242 Q9UBE8 NLK    HPRD  PubMed  
    P10242 Q02548 PAX5    HPRD  PubMed  
    P10242 P29590 PML    HPRD  PubMed  
    P10242 RQCD1 RQCD1    HPRD  PubMed  
    P10242 Q7KZF4 SND1    HPRD  PubMed  
    P10242 Q9UNY4 TTF2    HPRD  PubMed  
    P10242 P63279 UBE2I    HPRD  PubMed  
    P10242 Q15911 ZFHX3    HPRD  PubMed  
    BioGRID:110687 BioGRID:114528 ASH2L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:107480 CEBPB    BioGRID  PubMed Co-crystal Structure 
    BioGRID:110687 BioGRID:107482 CEBPE    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110687 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:110687 BioGRID:108347 EP300    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:110687 BioGRID:120581 FBXW7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110687 BioGRID:206088 Fbxw7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:108895 GATA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:118815 HIPK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110687 BioGRID:109376 HLF    BioGRID  PubMed Two-hybrid 
    BioGRID:110687 BioGRID:114375 KAT2B    BioGRID  PubMed Co-localization 
    BioGRID:110687 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:119354 LEF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:110269 MAF    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110687 BioGRID:110384 MEN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:110443 MLL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:119685 NLK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110687 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:111113 PAX5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:111864 RBBP5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:112044 RPL4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:112479 SMARCA2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110687 BioGRID:117974 SND1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110687 BioGRID:112555 SP100    BioGRID  PubMed Two-hybrid 
    BioGRID:110687 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110687 BioGRID:114036 TTF2    BioGRID  PubMed Two-hybrid 
    BioGRID:110687 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:110687 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110687 BioGRID:115989 ZMYND11    BioGRID  PubMed Reconstituted Complex; Two-hybrid 

    General gene information

    Markers

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    Component Evidence Code Pubs
    nuclear matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transcriptional activator Myb
    Names
    transcriptional activator Myb
    c-myb8B_CDS
    c-myb10A_CDS
    c-myb13A_CDS
    c-myb14A_CDS
    proto-oncogene c-Myb
    c-myb protein (140 AA)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012330.1 RefSeqGene

      Range
      5001..42859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130172.1NP_001123644.1  transcriptional activator Myb isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal segment and an exon in the coding region, as compared to variant 1. The reading frame is not affected, so the resulting isoform (3) lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AJ606320, D25774
      Consensus CDS
      CCDS47482.1
      UniProtKB/Swiss-Prot
      P10242
      Related
      ENSP00000410825, OTTHUMP00000234321, ENST00000442647, OTTHUMT00000391709
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 162
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 146
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 183
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:399564
      Blast Score: 640
      Cmyb_C; C-myb, C-terminal
    2. NM_001130173.1NP_001123645.1  transcriptional activator Myb isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AJ606319, D25774
      Consensus CDS
      CCDS47481.1
      UniProtKB/Swiss-Prot
      P10242
      Related
      ENSP00000339992, OTTHUMP00000017259, ENST00000341911, OTTHUMT00000042348
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 166
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 147
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 186
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:518688
      Blast Score: 658
      Cmyb_C; C-myb, C-terminal
    3. NM_001161656.1NP_001155128.1  transcriptional activator Myb isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.
      Source sequence(s)
      AL023693
      Consensus CDS
      CCDS55058.1
      UniProtKB/TrEMBL
      E9PNL6
      Related
      ENSP00000434723, OTTHUMP00000234431, ENST00000528774, OTTHUMT00000391902
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 166
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 147
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 186
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:515685
      Blast Score: 659
      Cmyb_C; C-myb, C-terminal
    4. NM_001161657.1NP_001155129.1  transcriptional activator Myb isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.
      Source sequence(s)
      AL023693
      Consensus CDS
      CCDS55061.1
      UniProtKB/TrEMBL
      E9PRS2
      Related
      ENSP00000435938, OTTHUMP00000234322, ENST00000525369, OTTHUMT00000391710
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 159
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 144
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 180
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:317482
      Blast Score: 641
      Cmyb_C; C-myb, C-terminal
    5. NM_001161658.1NP_001155130.1  transcriptional activator Myb isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 6) compared to isoform 1.
      Source sequence(s)
      AL023693
      Consensus CDS
      CCDS55059.1
      UniProtKB/TrEMBL
      E9PNA4
      Related
      ENSP00000432851, OTTHUMP00000234432, ENST00000534121, OTTHUMT00000391903
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 166
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 148
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 186
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:502672
      Blast Score: 658
      Cmyb_C; C-myb, C-terminal
    6. NM_001161659.1NP_001155131.1  transcriptional activator Myb isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 7, which is shorter than isoform 1.
      Source sequence(s)
      AL023693
      Consensus CDS
      CCDS55060.1
      UniProtKB/TrEMBL
      E9PLZ5
      Related
      ENSP00000435055, OTTHUMP00000234392, ENST00000534044, OTTHUMT00000391844
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 162
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 145
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 182
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:402594
      Blast Score: 520
      Cmyb_C; C-myb, C-terminal
    7. NM_001161660.1NP_001155132.1  transcriptional activator Myb isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two alternate in-frame segments in the coding region, as compared to variant 1. This variant encodes isoform 8, which is shorter than isoform 1.
      Source sequence(s)
      AL023693
      Consensus CDS
      CCDS55062.1
      UniProtKB/TrEMBL
      E9PI07
      Related
      ENSP00000436605, OTTHUMP00000234393, ENST00000533624, OTTHUMT00000391846
      Conserved Domains (3) summary
      cd00167
      Location:94138
      Blast Score: 163
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      smart00717
      Location:92140
      Blast Score: 183
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:367532
      Blast Score: 641
      Cmyb_C; C-myb, C-terminal
    8. NM_005375.2NP_005366.2  transcriptional activator Myb isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC035996, BC064955, X52125, X52126
      Consensus CDS
      CCDS5174.1
      UniProtKB/Swiss-Prot
      P10242
      UniProtKB/TrEMBL
      Q14025
      UniProtKB/TrEMBL
      Q708E9
      Related
      ENSP00000356788, OTTHUMP00000017258, ENST00000367814, OTTHUMT00000042347
      Conserved Domains (4) summary
      cd00167
      Location:94138
      Blast Score: 163
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam07988
      Location:266313
      Blast Score: 146
      LMSTEN; LMSTEN motif
      smart00717
      Location:92140
      Blast Score: 183
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam09316
      Location:402567
      Blast Score: 639
      Cmyb_C; C-myb, C-terminal

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      135502453..135540311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      133066684..133104587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL023693.25 CAI20197.1
      CAI20198.1
      CAI20199.1
      CAI20200.1
    genomic CH471051.2 EAW47967.1
      EAW47968.1
      EAW47969.1
      EAW47970.1
      EAW47971.1
      EAW47972.1
      EAW47973.1
      EAW47974.1
      EAW47975.1
      EAW47976.1
      EAW47977.1
      EAW47978.1
    genomic FB659824.1 CAS01767.1
    genomic GU324928.1 ADL14499.1
    genomic HH970061.1 CBX51725.1
    genomic M95584.1 AAA72118.1
    genomic U22376.1 AAB49034.1
      AAB49035.1
      AAB49036.1
      AAB49037.1
      AAB49038.1
      AAB49039.1
    mRNA AF104863.1 AAC96326.1
    mRNA AJ606317.1 CAE55168.1
    mRNA AJ606318.1 CAE55169.1
    mRNA AJ606319.1 CAE55170.1
    mRNA AJ606320.1 CAE55171.1
    mRNA AJ606321.1 CAE55172.1
    mRNA AJ606322.1 CAE55173.1
    mRNA AJ606323.1 CAE55174.1
    mRNA AJ606324.1 CAE55175.1
    mRNA AJ616235.1 CAE82649.1
    mRNA AJ616791.1 CAF04477.1
      CAF04478.1
      CAF04479.1
      CAF04480.1
      CAF04481.1
      CAF04482.1
      CAF04483.1
      CAF04484.1
      CAF04485.1
    mRNA AJ616792.1 None
    mRNA AJ616793.1 None
    mRNA AJ616794.1 None
    mRNA AJ616795.1 None
    mRNA AJ616796.4 None
    mRNA AJ616797.1 None
    mRNA AJ616801.1 None
    mRNA AJ616802.1 None
    mRNA AJ616805.1 None
    mRNA AY787443.1 None
    mRNA AY787444.1 None
    mRNA AY787445.1 None
    mRNA AY787446.1 None
    mRNA AY787447.1 None
    mRNA AY787448.1 None
    mRNA AY787449.1 None
    mRNA AY787450.1 None
    mRNA AY787451.1 None
    mRNA AY787452.1 None
    mRNA AY787453.1 None
    mRNA AY787454.1 None
    mRNA AY787455.1 None
    mRNA AY787456.1 None
    mRNA AY787457.1 None
    mRNA AY787458.1 None
    mRNA AY787459.1 None
    mRNA AY787460.1 None
    mRNA AY787461.1 None
    mRNA AY787462.1 None
    mRNA AY787463.1 None
    mRNA AY787464.1 None
    mRNA AY787465.1 None
    mRNA AY787466.1 None
    mRNA AY787467.1 None
    mRNA AY787468.1 None
    mRNA AY787469.1 None
    mRNA AY787470.1 None
    mRNA AY787471.1 None
    mRNA AY787472.1 None
    mRNA AY787473.1 None
    mRNA AY787474.1 None
    mRNA AY787475.1 None
    mRNA BC035996.1 None
    mRNA BC064955.1 AAH64955.1
    mRNA D25774.1 None
    mRNA M13665.1 AAA52030.1
    mRNA M13666.1 AAA52031.1
    mRNA M15024.1 AAA52032.1
    mRNA X17469.1 CAA35503.1
    mRNA X52125.1 CAA36371.1
    mRNA X52126.1 CAA36372.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10242.2 GenPept UniProtKB/Swiss-Prot:P10242
    Q14025 GenPept UniProtKB/TrEMBL:Q14025
    Q5THS4 GenPept UniProtKB/TrEMBL:Q5THS4
    Q5THS5 GenPept UniProtKB/TrEMBL:Q5THS5
    Q5THS6 GenPept UniProtKB/TrEMBL:Q5THS6
    Q708E1 GenPept UniProtKB/TrEMBL:Q708E1
    Q708E2 GenPept UniProtKB/TrEMBL:Q708E2
    Q708E3 GenPept UniProtKB/TrEMBL:Q708E3
    Q708E5 GenPept UniProtKB/TrEMBL:Q708E5
    Q708E6 GenPept UniProtKB/TrEMBL:Q708E6
    Q708E8 GenPept UniProtKB/TrEMBL:Q708E8
    Q708E9 GenPept UniProtKB/TrEMBL:Q708E9
    Q708J0 GenPept UniProtKB/TrEMBL:Q708J0
    Q70AC3 GenPept UniProtKB/TrEMBL:Q70AC3
    Q9UMI7 GenPept UniProtKB/TrEMBL:Q9UMI7

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