mts microtubule star [Drosophila melanogaster] - Gene

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Summary

Official Symbol: mtsprovided by Flybase
Official Full Name: microtubule starprovided by Flybase
Primary source: FLYBASE:FBgn0004177
Locus tag: Dmel_CG7109
Gene type: protein coding
RNA name: microtubule star
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5559; CG7109; Dmel\CG7109; DmPp2A-28D; dPP2A; ER2-6; l(2)02496; l(2)s5286; Mts; MTS/PP2A; PP2; Pp2A; PP2a; PP2A; PP2a 28D; PP2A 28D; PP2A C; Pp2A-28D; PP2A-C; PP2Ac; PP2A[C]; PP2A[[C]]

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Genomic context

Location :: 28D1-28D2

Sequence :: Chromosome: 2L; NT_033779.4 (7827743..7832745)

See mts in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identify the dSTRIPAK PP2A complex as a major regulator of Hpo signaling. dSTRIPAK depletion leads to increased Hpo activation and repression of Yki target genes in vivo, suggesting this phosphatase complex prevents Hpo activation during development.
Title: Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.
findings suggest antagonistic roles for CK2 and PP2A during inhibitory Notch signaling.
Title: Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.
PP2A suppresses aPKC signaling by promoting Par-6 dephosphorylation in neuroblasts, which uncovers a novel balancing mechanism for aPKC signaling in the regulation of asymmetric cell division.
Title: Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions.
mts is necessary for full activation of Hh signaling.
Title: A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:70018	BioGRID:62301	Aats-phe	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:66029	Ama	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:59536	Atg4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:58653	Bap60	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:67510	C15	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:68413	CG11504	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:64022	CG12607	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:65192	CG13022	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:62121	CG13159	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:67654	CG13840	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:59255	CG14207	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:65751	CG14641	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:65853	CG14667	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:68471	CG2224	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:59694	CG2862	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:57891	CG2982	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:58343	CG3004	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:77150	CG31626	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:77514	CG33138	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:58628	CG4407	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:64453	CG4641	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:60551	CG6443	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:67643	CG6985	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:60253	CG8349	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:59311	CG9578	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:63273	CG9876	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:63844	CG9977	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:58322	Dsor1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:70018	BioGRID:61232	Hakai	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:68868	Hmgs	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:64139	Jon65Aiv	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:66914	MRG15	BioGRID	PubMed	Affinity Capture-MS; Two-hybrid
BioGRID:70018	BioGRID:58444	Myo10A	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:67574	PSR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:77789	Pp2A-29B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:70018	BioGRID:67703	RpS3	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:58056	Rpt4	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:67729	SPE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:65316	Sgf11	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:59325	Syx16	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:77420	Tap42	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:61392	Tif-IA	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:59895	Trip1	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:64396	Zasp66	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:69091	br	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:58076	dx	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:60057	frj	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:60376	gcm	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:62421	igl	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:75540	pen-2	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:57758	phl	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:70018	BioGRID:57644	png	BioGRID	PubMed	Phenotypic Suppression
BioGRID:70018	BioGRID:68777	sol	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:65697	srpk79D	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:65303	star1	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:69276	tan	BioGRID	PubMed	Affinity Capture-MS
BioGRID:70018	BioGRID:70682	term	BioGRID	PubMed	Two-hybrid
BioGRID:70018	BioGRID:68196	wdb	BioGRID	PubMed	Affinity Capture-MS; Phenotypic Suppression

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General gene information

Markers

Dm0670 (e-PCR)
- UniSTS:21911

Homology

Homologs of the mts gene: The mts gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, and rice.

Pathways from BioSystems

Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
Beta-catenin phosphorylation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
CTLA4 inhibitory signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ERK/MAPK targets, organism-specific biosystem (from REACTOME)
ERK/MAPK targets, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ERKs are inactivated, organism-specific biosystem (from REACTOME)
ERKs are inactivated, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glucose metabolism, organism-specific biosystem (from REACTOME)
Glucose metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
Glycolysis, organism-specific biosystem (from REACTOME)
Glycolysis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
MAP kinase activation in TLR cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystem (from REACTOME)
NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nuclear Events (kinase and transcription factor activation), organism-specific biosystem (from REACTOME)
Nuclear Events (kinase and transcription factor activation), organism-specific biosystemcomputationally inferred pathway (not manually curated)
PP2A-mediated dephosphorylation of key metabolic factors, organism-specific biosystem (from REACTOME)
PP2A-mediated dephosphorylation of key metabolic factors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystem (from REACTOME)
TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
TRIF mediated TLR3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
Toll Receptor Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
mRNA surveillance pathway, organism-specific biosystem (from KEGG)
mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
mRNA surveillance pathway, conserved biosystem (from KEGG)
mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein serine/threonine phosphatase activity	NAS Non-traceable Author Statement more info

Process	Evidence Code	Pubs
R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
centrosome duplication	IMP Inferred from Mutant Phenotype more info
chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
establishment of epithelial cell polarity	IEP Inferred from Expression Pattern more info	PubMed
microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
protein dephosphorylation	NAS Non-traceable Author Statement more info
regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
response to light stimulus	IGI Inferred from Genetic Interaction more info	PubMed
spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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General protein information

Preferred Names: CG7109 gene product from transcript CG7109-RA

Names: CG7109-PA; PP2A catalytic subunit; catalytic subunit C of type 2A protein phosphatase; microtubule star; mts-PA; phosphatase 2A catalytic subunit; protein phosphatase 2A; protein phosphatase 2A at 28D

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

7827743..7832745

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057457.3 → NP_476805.1 microtubule star [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P23696

Related

FBpp0079148, FBtr0079525

Conserved Domains (2) summary

cd07415
Location:9 – 293
Blast Score: 1574

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

PTZ00239
Location:8 – 309
Blast Score: 1110

PTZ00239; serine/threonine protein phosphatase 2A; Provisional