ImpL3 Ecdysone-inducible gene L3 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: ImpL3provided by Flybase
Official Full Name: Ecdysone-inducible gene L3provided by Flybase
Primary source: FLYBASE:FBgn0001258
Locus tag: Dmel_CG10160
Gene type: protein coding
RNA name: Ecdysone-inducible gene L3
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10160; dLdha; Dmel\CG10160; dmLDH; Imp-L3; IMP-L3; Impl3; IMPL3; Ld; Ldh; LDH

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Genomic context

Location :: 65A11-65A11

Sequence :: Chromosome: 3L; NT_037436.3 (6252592..6255793, complement)

See ImpL3 in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:69949	BioGRID:68371	ATPsyn-gamma	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:68649	Arf102F	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:65734	Arf79F	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:60592	Art8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:67962	CG10425	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:60093	CG11327	BioGRID	PubMed	Two-hybrid
BioGRID:69949	BioGRID:64295	CG12262	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:63211	CG13510	BioGRID	PubMed	Two-hybrid
BioGRID:69949	BioGRID:61370	CG1416	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:58177	CG1444	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:62842	CG15098	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:65052	CG17029	BioGRID	PubMed	Two-hybrid
BioGRID:69949	BioGRID:61582	CG2064	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:61581	CG2065	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:59487	CG2789	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:77765	CG33303	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:65149	CG4169	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:67767	CG5854	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:60408	CG5885	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:62714	CG6370	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:61052	CG6453	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:67177	CG7357	BioGRID	PubMed	Two-hybrid
BioGRID:69949	BioGRID:72161	Ca-P60A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:67074	Cctgamma	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:58885	Chc	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:66729	Droj2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:63631	Gale	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:66144	Gie	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:68235	Gp93	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:59949	Hel25E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:60508	KdelR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:60023	Kr-h2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:59210	Mec2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:58304	Ost48	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:59383	Pros45	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:67578	PyK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:63773	R	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:67494	Rab1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:61475	Rab2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:59646	Rab5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:63429	Rap2l	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:61576	Rpt1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:63945	Sc2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:65076	SsRbeta	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:68766	Sucb	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:69807	Tapdelta	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:58868	Tcp-1zeta	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:63229	blw	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:69548	cathD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:69656	ox	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:60572	porin	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:69060	sec13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:66236	skap	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69949	BioGRID:62039	wal	BioGRID	PubMed	Affinity Capture-MS

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General gene information

Homology

Homologs of the ImpL3 gene: The ImpL3 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
Cysteine and methionine metabolism, conserved biosystem (from KEGG)
Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
Glycolysis and Gluconeogenesis, organism-specific biosystem
Glycolysis and Gluconeogenesis
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Propanoate metabolism, organism-specific biosystem (from KEGG)
Propanoate metabolism, organism-specific biosystem
Propanoate metabolism
Propanoate metabolism, conserved biosystem (from KEGG)
Propanoate metabolism, conserved biosystem
Propanoate metabolism
Pyruvate metabolism, organism-specific biosystem (from KEGG)
Pyruvate metabolism, organism-specific biosystem
Pyruvate metabolism
Pyruvate metabolism, organism-specific biosystem (from REACTOME)
Pyruvate metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pyruvate metabolism, conserved biosystem (from KEGG)
Pyruvate metabolism, conserved biosystem
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
L-lactate dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
L-lactate dehydrogenase activity	NAS Non-traceable Author Statement more info
L-lactate dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
glycolysis	IEA Inferred from Electronic Annotation more info
glycolysis	NAS Non-traceable Author Statement more info
oxidation-reduction process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info

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General protein information

Preferred Names: CG10160 gene product from transcript CG10160-RA

Names: CG10160-PA; Ecdysone-induced gene L3; Ecdysone-inducible gene L3; ImpL3-PA; lactate dehydrogenase; lactate dehydrogenase B; lactate/malate dehydrogenease; lactic DH

NP_476581.1

EC 1.1.1.27

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

6252592..6255793, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057233.4 → NP_476581.1 Ecdysone-inducible gene L3 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

B5RJQ0

UniProtKB/Swiss-Prot

Q95028

Related

FBpp0076716

Conserved Domains (2) summary

cd05293
Location:18 – 329
Blast Score: 1368

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:25 – 323
Blast Score: 1001

L-LDH-NAD; L-lactate dehydrogenase