eIF-3p40 Eukaryotic initiation factor 3 p40 subunit [Drosophila melanogaster] - Gene

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Summary

Official Symbol: eIF-3p40provided by Flybase
Official Full Name: Eukaryotic initiation factor 3 p40 subunitprovided by Flybase
Primary source: FLYBASE:FBgn0022023
Locus tag: Dmel_CG9124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM14618; CG9124; Dmel\CG9124; eIF-3; eIf3-p44; eIF3-S3; l(2)k09003

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Genomic context

Location :: 25C3-25C3

Sequence :: Chromosome: 2L; NT_033779.4 (5051193..5053209, complement)

See eIF-3p40 in Epigenomics, MapViewer

Chromosome 2L - NT_033779.4 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:69808	BioGRID:63100	CG10306	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:59096	CG12985	BioGRID	PubMed	Two-hybrid
BioGRID:69808	BioGRID:61207	CG13084	BioGRID	PubMed	Two-hybrid
BioGRID:69808	BioGRID:58851	CG15646	BioGRID	PubMed	Two-hybrid
BioGRID:69808	BioGRID:64740	CG5642	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:66178	CG7352	BioGRID	PubMed	Two-hybrid
BioGRID:69808	BioGRID:57774	CG8636	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:65804	CG9769	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:65176	Int6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:62316	Tango7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:68341	Trc8	BioGRID	PubMed	Reconstituted Complex
BioGRID:69808	BioGRID:65782	eIF3-S10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:62691	eIF3-S8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:69808	BioGRID:62670	eIF3-S9	BioGRID	PubMed	Affinity Capture-MS

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General gene information

Homology

Homologs of the eIF-3p40 gene: The eIF-3p40 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
Cap-dependent Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
Eukaryotic Translation Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA transport, organism-specific biosystem (from KEGG)
RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
RNA transport, conserved biosystem (from KEGG)
RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
Ribosomal scanning and start codon recognition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation Factors, organism-specific biosystem (from WikiPathways)
Translation Factors, organism-specific biosystem
Translation Factors

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
neurogenesis	IMP Inferred from Mutant Phenotype more info
translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info

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General protein information

Preferred Names: CG9124 gene product from transcript CG9124-RA

Names: CG9124-PA; CG9124-PB; eIF-3p40-PA; eIF-3p40-PB; eukaryotic initiation factor 3 p40 subunit

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.4

Range

5051193..5053209, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080095.3 → NP_524834.2 eukaryotic initiation factor 3 p40 subunit, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U9Q4

Related

FBpp0078667, FBtr0079030

Conserved Domains (1) summary

cd08065
Location:20 – 281
Blast Score: 908

MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
NM_205909.2 → NP_995631.1 eukaryotic initiation factor 3 p40 subunit, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U9Q4

Related

FBpp0089133, FBtr0079031

Conserved Domains (1) summary

cd08065
Location:20 – 281
Blast Score: 908

MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h