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ADAP2 ArfGAP with dual PH domains 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 454561, updated on 3-Apr-2024

Summary

Official Symbol
ADAP2provided by VGNC
Official Full Name
ArfGAP with dual PH domains 2provided by VGNC
Primary source
VGNC:VGNC:6328
Locus tag
CK820_G0028560
See related
Ensembl:ENSPTRG00000008966
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
CENTA2
Orthologs
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Genomic context

Location:
chromosome: 17
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 19 NC_072417.2 (36689880..36732067, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 17 NC_072415.1 (34874337..34913783, complement)

Chromosome 19 - NC_072417.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104002875 Neighboring gene ring finger protein 135 Neighboring gene divergent paired-related homeobox-like Neighboring gene transcription elongation factor, mitochondrial Neighboring gene ATPase family AAA domain containing 5 Neighboring gene uncharacterized LOC134808873

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables phosphatidylinositol bisphosphate binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in heart development IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
arf-GAP with dual PH domain-containing protein 2
Names
centaurin, alpha 2
centaurin-alpha 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072417.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    36689880..36732067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016932045.4XP_016787534.1  arf-GAP with dual PH domain-containing protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A2J8LIT6
  2. XM_063798738.1XP_063654808.1  arf-GAP with dual PH domain-containing protein 2 isoform X9

  3. XM_016932042.4XP_016787531.1  arf-GAP with dual PH domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A2J8LIT6
  4. XM_024350672.3XP_024206440.1  arf-GAP with dual PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A2J8LIT6
    Conserved Domains (3) summary
    cd01251
    Location:261367
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:139247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8132
    ArfGap; Putative GTPase activating protein for Arf
  5. XM_054670087.2XP_054526062.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

  6. XM_016932040.4XP_016787529.1  arf-GAP with dual PH domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8LIT6
  7. XM_024350673.3XP_024206441.1  arf-GAP with dual PH domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A2J8LIT6
    Conserved Domains (3) summary
    cd01251
    Location:255361
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8126
    ArfGap; Putative GTPase activating protein for Arf
  8. XM_009432450.5XP_009430725.1  arf-GAP with dual PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A2J8LIT6
    Conserved Domains (4) summary
    cd01251
    Location:255362
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam00169
    Location:258361
    PH; PH domain
    pfam01412
    Location:8126
    ArfGap; Putative GTPase activating protein for Arf
  9. XM_016932044.4XP_016787533.1  arf-GAP with dual PH domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A2J8LIT6, A0A2J8LIU4, A0A6D2W689, H2QCL8
    Related
    ENSPTRP00000015304.5
    Conserved Domains (3) summary
    cd01251
    Location:261368
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:139247
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8132
    ArfGap; Putative GTPase activating protein for Arf
  10. XM_001174772.7XP_001174772.1  arf-GAP with dual PH domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A2J8LIT3, A0A2J8LIT6
    Conserved Domains (3) summary
    cd01251
    Location:255362
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:133241
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    pfam01412
    Location:8126
    ArfGap; Putative GTPase activating protein for Arf
  11. XM_054670088.2XP_054526063.1  arf-GAP with dual PH domain-containing protein 2 isoform X10

  12. XM_009432452.5XP_009430727.1  arf-GAP with dual PH domain-containing protein 2 isoform X10

    Conserved Domains (3) summary
    cd01251
    Location:179286
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:57165
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    cl28907
    Location:141
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)