Dr Drop [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Drprovided by FlyBase
Official Full Name: Dropprovided by FlyBase
Primary source: FLYBASE:FBgn0000492
Locus tag: Dmel_CG1897
See related: AllianceGenome:FB:FBgn0000492
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 153515_at; 99B; CG1897; Dmel\CG1897; Dr/msh; Dr/Msh; l(3)FA30; ltt; msh; Msh; msh-1; msh1; Msx
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including imaginal disc development; nervous system development; and regulation of cell fate specification. Located in nucleus. Is expressed in several structures, including ectoderm anlage; extended germ band embryo; germ layer; presumptive embryonic/larval system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including cleft lip; orofacial cleft 5; parietal foramina; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1) and MSX2 (msh homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 99B3-99B3; 3-99 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29556386..29565244)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25382108..25390966)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The phosphorylation of Hbn, Ems, and Msh may provide further insight into the function of Hipk during development of the Drosophila nervous system.
Title: Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
cross-repression between Ind and Msh stabilizes the border between intermediate and dorsal tritocerebrum and deutocerebrum, and that both transcription factors are competent to inhibit vnd expression
Title: Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord.
expression is expanded ventrally in ind mutant embryos and Ind protein directly and specifically bound to the msh regulatory DNA, and this interaction was required to limit the ventral boundary of msh expression.
Title: Ind represses msh expression in the intermediate column of the Drosophila neuroectoderm, through direct interaction with upstream regulatory DNA.
Data show that expression of gene msh is invloved in dorsoventral regionalization within the developing brain and truncal nervous system in Drosophilia.
Title: Dorsoventral patterning of the brain: a comparative approach.
Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.
Title: Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in dorsal/ventral pattern formation	TAS Traceable Author Statement more info	PubMed
involved_in dorsal/ventral pattern formation, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectoderm development	TAS Traceable Author Statement more info	PubMed
involved_in embryonic morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	NAS Non-traceable Author Statement more info	PubMed
involved_in ventral cord development	TAS Traceable Author Statement more info	PubMed
involved_in wing and notum subfield formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: drop

Names: CG1897-PA; Dr-PA; Dr-distal; lottchen; muscle segment homeobox; muscle specific homeobox; muscle-specific homeodomain; muscle-specific homeodomain 1