CYTB cytochrome b [Homo sapiens] - Gene

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Summary

Gene symbol: CYTB
Gene description: cytochrome b
Primary source: HGNC:7427
See related: MIM:516020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTCYB

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Genomic context

Location :: tissue type: placenta, isolation source: caucasian, country: United Kingdom: Great Britain

Sequence :: Chromosome: MT; NC_012920.1 (14747..15887)

See CYTB in Epigenomics, MapViewer

Chromosome MT - NC_012920.1 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis.
Title: Enhanced transcription of estrogen receptor α and mitochondrial cytochrome b genes in uterine leiomyomas.
Data show that homoplasmic G6709A (MT-CO1) and G14804A (MT-CYB) alterations cause amino acid changes in the highly conserved residues.
Title: Mitochondrial DNA alterations in colorectal cancer cell lines.
mitocryptide-2 (MCT-2) and its human homolog hMCT-2 are cryptides that activate neutrophils
Title: Mitocryptide-2: purification, identification, and characterization of a novel cryptide that activates neutrophils.
cytochrome B gene mutation induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells.
Title: Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells.
The m.15635T>C transition (S297P) was carried by a newborn who presented with a polyvisceral failure.
Title: A neonatal polyvisceral failure linked to a de novo homoplasmic mutation in the mitochondrially encoded cytochrome b gene.
CytbI7T has a role in longevity related to caloric restriction
Title: Evolutionary pressure on mitochondrial cytochrome b is consistent with a role of CytbI7T affecting longevity during caloric restriction.
Trx2 overexpression modulates the mRNA levels of the COX1 (cytochrome oxidase subunit I) and Cytb (cytochrome b), which are known to be regulated by GR and NF-kappaB.
Title: Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells.
caspase 8-dependent cleavage of mitochondrial Cyt b and translocation of its C-terminal half into the cytoplasm occurred during FAS-induced apoptosis in both chicken and human cells
Title: Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Mitochondrial DNA variant interactions modify breast cancer risk.
Observational study of gene-disease association. (HuGE Navigator)
Title: MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease.

Submit: New GeneRIF Correction See all (14)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

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General gene information

Markers

D1S2076E (e-PCR)
- UniSTS:151706

GDB:451664 (e-PCR)
- UniSTS:157340

PMC55343P10 (e-PCR)
- UniSTS:273323

PMC55343P12 (e-PCR)
- UniSTS:273324

PMC55343P9 (e-PCR)
- UniSTS:273332

D5S1608E (e-PCR)
- UniSTS:151029

Genotypes

Pathways from BioSystems

Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Cardiac muscle contraction, organism-specific biosystem (from KEGG)
Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
Cardiac muscle contraction, conserved biosystem (from KEGG)
Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
Cytochrome bc1 complex, organism-specific biosystem (from KEGG)
Cytochrome bc1 complex, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
Cytochrome bc1 complex, conserved biosystem (from KEGG)
Cytochrome bc1 complex, conserved biosystemStructural complex; Energy metabolism; ATP synthesis
Cytochrome bc1 complex respiratory unit, organism-specific biosystem (from KEGG)
Cytochrome bc1 complex respiratory unit, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
Cytochrome bc1 complex respiratory unit, conserved biosystem (from KEGG)
Cytochrome bc1 complex respiratory unit, conserved biosystemStructural complex; Energy metabolism; ATP synthesis
Electron Transport Chain, organism-specific biosystem (from WikiPathways)
Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Oxidative phosphorylation, organism-specific biosystem (from KEGG)
Oxidative phosphorylation, organism-specific biosystem
Oxidative phosphorylation
Oxidative phosphorylation, conserved biosystem (from KEGG)
Oxidative phosphorylation, conserved biosystem
Oxidative phosphorylation
Parkinson's disease, organism-specific biosystem (from KEGG)
Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL...
Respiratory electron transport, organism-specific biosystem (from REACTOME)
Respiratory electron transport, organism-specific biosystemMitochondria are often described as the "powerhouse" of a cell as it is here that energy is largely released from the oxidation of food. Reducing equivalents generated from beta-oxidation of fatty ac...
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem (from REACTOME)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystemOxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of ...
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...

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General protein information

Names: cytochrome b

YP_003024038.1

TAA stop codon is completed by the addition of 3' A residues to the mRNA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

mRNA and Protein(s)

YP_003024038.1 cytochrome b [Homo sapiens]

UniProtKB/Swiss-Prot

P00156

UniProtKB/TrEMBL

Q0ZFD6

Conserved Domains (3) summary

cd00284
Location:9 – 206
Blast Score: 644

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

cd00290
Location:207 – 354
Blast Score: 264

cytochrome_b_C; Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

MTH00100
Location:1 – 379
Blast Score: 1687

CYTB; cytochrome b; Provisional