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MTCP1 mature T-cell proliferation 1 [ Homo sapiens (human) ]

Gene ID: 4515, updated on 8-May-2016
Official Symbol
MTCP1provided by HGNC
Official Full Name
mature T-cell proliferation 1provided by HGNC
Primary source
HGNC:HGNC:7423
See related
Ensembl:ENSG00000214827 HPRD:02122; MIM:300116; Vega:OTTHUMG00000156241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p8MTCP1; P13MTCP1
Summary
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009]
Annotation information
Note: Prior to build 37.1, geneID:4515 (MTCP1) was annotated as a single locus expressing transcripts with two distinct protein products. The locus was subsequently split into two geneIDs, with geneID:4515 representing the upstream locus (MTCP1, aka isoform p13) and geneID:100272147 representing the downstream locus (MTCP1NB, aka isoform p8). [13 Feb 2013]
Orthologs
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (155064034..155071272, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154292309..154299547, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene zinc finger protein 622 pseudogene Neighboring gene FUN14 domain containing 2 Neighboring gene C-x(9)-C motif containing 4 Neighboring gene BRCA1/BRCA2-containing complex subunit 3 Neighboring gene VHL binding protein 1

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with MTCP1 promoter to upregulate MTCP1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein p13 MTCP-1
Names
MTCP-1 type B1
mature T-cell proliferation 1 isoform p13
mature T-cell proliferation-1 type B1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029506.1 RefSeqGene

    Range
    5001..12239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018025.3NP_001018025.1  protein p13 MTCP-1

    See identical proteins and their annotated locations for NP_001018025.1

    Status: REVIEWED

    Source sequence(s)
    AA744518, AW976554, BX470111
    Consensus CDS
    CCDS44027.1
    UniProtKB/Swiss-Prot
    P56278
    Related
    ENSP00000358488, OTTHUMP00000024241, ENST00000369476, OTTHUMT00000058776
    Conserved Domains (1) summary
    pfam01840
    Location:2106
    TCL1_MTCP1; TCL1/MTCP1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    155064034..155071272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    154203936..154211174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014221.3: Suppressed sequence

    Description
    NM_014221.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.