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    Pp4-19C Protein phosphatase 19C [ Drosophila melanogaster ]

    Gene ID: 45031, updated on 10-May-2012
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    Summary

    Official Symbol
    Pp4-19Cprovided by Flybase
    Official Full Name
    Protein phosphatase 19Cprovided by Flybase
    Primary source
    FLYBASE:FBgn0023177
    Locus tag
    Dmel_CG32505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1459; CG1596; CG18339; CG32505; Dmel\CG32505; DmPpp4-19C; PP1; pp4; PP4; PP4 19C; PP4C; PPP4c; PpX; PPX
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    Genomic context

    Location :
    19D1-19D1
    Sequence :
    Chromosome: X; NC_004354.3 (20292114..20295045, complement)
    See Pp4-19C in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 19c Neighboring gene Pheromone-binding protein-related protein 2 Neighboring gene CG1676 gene product from transcript CG1676-RA Neighboring gene CG15456 gene product from transcript CG15456-RA Neighboring gene CG11710 gene product from transcript CG11710-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. False negative rates in Drosophila cell-based RNAi screens: a case study. Booker M, et al. BMC Genomics, 2011 Jan 20. PMID 21251254.
    3. Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions. Sousa-Nunes R, et al. Commun Integr Biol, 2010 Jan. PMID 20539782.
    4. Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions. Sousa-Nunes R, et al. Genes Dev, 2009 Feb 1. PMID 19204120.
    5. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Jia H, et al. Development, 2009 Jan. PMID 19088085.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:69445 BioGRID:57795 CG2709    BioGRID  PubMed Two-hybrid 
    BioGRID:69445 BioGRID:58037 CG4666    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:69445 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:69445 BioGRID:62567 Cdk4    BioGRID  PubMed Two-hybrid 
    BioGRID:69445 BioGRID:61365 Cul-2    BioGRID  PubMed Two-hybrid 
    BioGRID:69445 BioGRID:68286 Doa    BioGRID  PubMed Two-hybrid 
    BioGRID:69445 BioGRID:58407 PPP4R2r    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:69445 BioGRID:64739 RhoGAP68F    BioGRID  PubMed Two-hybrid 
    BioGRID:69445 BioGRID:77420 Tap42    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:69445 BioGRID:71315 ttk    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Pp4-19C gene: The Pp4-19C gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    M phase specific microtubule process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG32505 gene product from transcript CG32505-RA
    Names
    CG32505-PA
    CG32505-PE
    Pp4-19C-PA
    Pp4-19C-PE
    protein phosphatase 1
    protein phosphatase 19C
    protein phosphatase X
    NP_524803.1
    NP_728342.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      20292114..20295045, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080064.2 → NP_524803.1  protein phosphatase 19C, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932
      Related
      FBpp0077016, FBtr0077324
      Conserved Domains (2) summary
      cd07415
      Location:6 – 290
      Blast Score: 1600
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      PTZ00239
      Location:6 – 307
      Blast Score: 1179
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional

    2. NM_167703.3 → NP_728342.1  protein phosphatase 19C, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76932
      Related
      FBpp0077017, FBtr0077325
      Conserved Domains (2) summary
      cd07415
      Location:6 – 290
      Blast Score: 1600
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
      PTZ00239
      Location:6 – 307
      Blast Score: 1179
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic Y14213.1 CAA74606.1
    genomic AE014298.4 AAF50905.1
    mRNA AY113503.1 AAM29508.1
    genomic AE014298.4 AAN09547.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF50906.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content