MT2A metallothionein 2A [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: MT2Aprovided by HGNC
Official Full Name: metallothionein 2Aprovided by HGNC
Primary source: HGNC:7406
See related: Ensembl:ENSG00000125148; HPRD:08863; MIM:156360; Vega:OTTHUMG00000133281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT2

Help top of page

Genomic context

Location :: 16q13

Sequence :: Chromosome: 16; NC_000016.9 (56642478..56643409)

See MT2A in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Possible role of MT as a marker of cell stress and homeostasis restoration in Graves'disease.
Title: Overexpression of metallothionein I/II: a new feature of thyroid follicular cells in Graves' disease.
these data support that the IL-6 -174 C+ carriers and MT2A -5 G- carriers may be more advantageous for longevity.
Title: Distributions of interleukin-6 (IL-6) promoter and metallothionein 2A (MT2A) core promoter region gene polymorphisms and their associations with aging in Turkish population.
Highly statistically significant associations are detected between the -5 adenine/guanine core promoter region single nucleotide polymorphism in the MT2A gene and cadmium, lead, and zinc (but not copper) blood levels.
Title: The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels.
Data suggest that increase in cell size, intracellular granulation and megakaryocytic specific antigen expression such as CD41 and CD42, and arresting cell proliferation validate the role of metallothioneins in cell differentiation.
Title: Role of metallothionein in differentiation of leukemia cells.
MT-I/II may play a key role in IDC proliferation, but is not a useful prognostic factor of this disease
Title: Correlation of intensity of MT-I/II expression with Ki-67 and MCM-2 proteins in invasive ductal breast carcinoma.
MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts.
Title: Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
MT-2A promotes breast cancer cell invasion by upregulating MMP-9 via AP-1 and NF-kappaB activation.
Title: Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells.
metallothioneins represented by MT-2A capable of protecting against Abeta aggregation and toxicity
Title: The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
MT2 diminishes Transthyretin-Abeta binding, whereas MT3 has the opposite effect
Title: Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin.

Submit: New GeneRIF Correction See all (41)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_005944.1	NP_115955.1	SPINK7	BIND	PubMed	ECRG2 interacts with MT2A.
P02795	O75173	ADAMTS4	HPRD	PubMed
P02795	Q8TE69	CXorf40A	HPRD	PubMed
P02795	Q15139	PRKD1	HPRD	PubMed
P02795	P04278	SHBG	HPRD	PubMed
P02795	P58062	SPINK7	HPRD	PubMed
BioGRID:110608	BioGRID:111573	PRKD1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110608	BioGRID:124174	SPINK7	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110608	BioGRID:118895	USP25	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
drug binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
cellular copper ion homeostasis	TAS Traceable Author Statement more info	PubMed
cellular response to drug	IDA Inferred from Direct Assay more info	PubMed
cellular response to erythropoietin	IEP Inferred from Expression Pattern more info	PubMed
cellular response to interleukin-3	IEP Inferred from Expression Pattern more info	PubMed
cellular response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	TAS Traceable Author Statement more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: metallothionein-2

Names: metallothionein-2; MT-2; MT-II; metallothionein-2A; metallothionein-II

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005953.3 → NP_005944.1 metallothionein-2

Status: VALIDATED

Source sequence(s)

BC007034, BM746626

Consensus CDS

CCDS10763.1

UniProtKB/Swiss-Prot

P02795

Related

ENSP00000245185, OTTHUMP00000164382, ENST00000245185, OTTHUMT00000257061

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

56642478..56643409

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

42512001..42512932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC026461.11 (78289..79173)	None
genomic	CH471092.1	EAW82869.1
		EAW82870.1
genomic	DQ370420.1	ABC79300.1
genomic	HI574296.1	CBX47637.1
genomic	J00271.1	AAA59583.1
genomic	M15244.1	None
genomic	X00504.1	CAA25196.1
mRNA	BC007034.1	AAH07034.1
mRNA	BC070289.1	AAH70289.1
mRNA	BM746626.1	None
mRNA	BT007315.1	AAP35979.1
mRNA	D28442.1	BAA05808.1
mRNA	M26637.1	AAA59584.1
mRNA	S52379.1	AAB24908.1
mRNA	V00594.1	CAA23841.1
mRNA	X97260.1	CAA65915.1
other-genetic	EU831459.1	ACE87146.1
other-genetic	EU831546.1	ACE86465.1