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    MT1M metallothionein 1M [ Homo sapiens ]

    Gene ID: 4499, updated on 11-May-2012
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    Summary

    Official Symbol
    MT1Mprovided by HGNC
    Official Full Name
    metallothionein 1Mprovided by HGNC
    Primary source
    HGNC:14296
    See related
    Ensembl:ENSG00000205364; HPRD:01129; MIM:156357; Vega:OTTHUMG00000176938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT1; MT1K; MT-1M; MT-IM; MGC40498; MGC118949
    Summary
    This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
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    Genomic context

    Location :
    16q13
    Sequence :
    Chromosome: 16; NC_000016.9 (56666534..56667898)
    See MT1M in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene metallothionein 1L (gene/pseudogene) Neighboring gene metallothionein 1E Neighboring gene metallothionein 1J, pseudogene Neighboring gene metallothionein 1A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. Lederer CW, et al. BMC Genomics, 2007 Jan 23. PMID 17244347.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Izmailova E, et al. Nat Med, 2003 Feb. PMID 12539042.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. Vandeghinste N, et al. Cell Mol Biol (Noisy-le-grand), 2000 Mar. PMID 10774930.

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Mineral absorption, organism-specific biosystem (from KEGG)
      Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Mineral absorption, conserved biosystem (from KEGG)
      Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    metallothionein-1M
    Names
    metallothionein-1M
    metallothionein 1K
    metallothionein 1Y
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030326.1 RefSeqGene

      Range
      5001..6365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176870.2 → NP_789846.1  metallothionein-1M

      Status: REVIEWED

      Source sequence(s)
      AF136177, BM918307
      Consensus CDS
      CCDS42166.1
      UniProtKB/Swiss-Prot
      Q8N339
      Related
      ENSP00000369146, OTTHUMP00000255423, ENST00000379818, OTTHUMT00000434359

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      56666534..56667898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      42535987..42537351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026461.11 (53791..55112) None
    genomic AF348671.1 AAL83902.1
    genomic CH471092.1 EAW82875.1
      EAW82876.1
    mRNA AF136177.1 AAP97267.1
    mRNA AF479613.1 AAL85413.1
    mRNA BC028280.1 AAH28280.1
    mRNA BC103841.1 AAI03842.1
    mRNA BM918307.1 None
    other-genetic DQ894755.2 ABM85681.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N339.2 GenPept UniProtKB/Swiss-Prot:Q8N339
    Q8TDC4 GenPept UniProtKB/TrEMBL:Q8TDC4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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