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MT1F metallothionein 1F [ Homo sapiens (human) ]

Gene ID: 4494, updated on 26-Aug-2014
Official Symbol
MT1Fprovided by HGNC
Official Full Name
metallothionein 1Fprovided by HGNC
Primary source
HGNC:7398
Locus tag
PRO0376
See related
HPRD:01127; MIM:156352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1
See MT1F in Epigenomics, MapViewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (56657943..56659303)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56691855..56693215)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene metallothionein 1C, pseudogene Neighboring gene metallothionein 1B Neighboring gene uncharacterized LOC101927536 Neighboring gene metallothionein 1G

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC32732

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to zinc ion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
metallothionein-1F
Names
metallothionein-1F
MT-1F
MT-IF
metallothionein-IF
metallothionein 1F (functional)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301272.1NP_001288201.1  metallothionein-1F isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a shorter isoform (2) with a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    BC029453, BM919862, W78077
    Conserved Domains (1) summary
    pfam00131
    Location:535
    Blast Score: 77
    Metallothio; Metallothionein
  2. NM_005949.3NP_005940.1  metallothionein-1F isoform 1

    See proteins identical to NP_005940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BC029453, BQ939879
    Consensus CDS
    CCDS32456.1
    UniProtKB/Swiss-Prot
    P04733
    Conserved Domains (1) summary
    pfam00131
    Location:559
    Blast Score: 95
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    56657943..56659303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    42561295..42562655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    58098782..58100142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)