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    MT1B metallothionein 1B [ Homo sapiens ]

    Gene ID: 4490, updated on 11-May-2012
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    Summary

    Official Symbol
    MT1Bprovided by HGNC
    Official Full Name
    metallothionein 1Bprovided by HGNC
    Primary source
    HGNC:7394
    See related
    Ensembl:ENSG00000169688; HPRD:11826; MIM:156349; Vega:OTTHUMG00000133277
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT1; MTP; MT1Q
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    Genomic context

    Location :
    16q13
    Sequence :
    Chromosome: 16; NC_000016.9 (56685811..56687116)
    See MT1B in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene metallothionein 1D, pseudogene Neighboring gene metallothionein 1C, pseudogene Neighboring gene metallothionein 1F Neighboring gene metallothionein 1G

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. Lederer CW, et al. BMC Genomics, 2007 Jan 23. PMID 17244347.
    2. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. Sun NN, et al. Toxicol Ind Health, 2003 Oct. PMID 15747776.
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    4. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Izmailova E, et al. Nat Med, 2003 Feb. PMID 12539042.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Copper/cadmium/zinc ore binding.
      Title: Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Mineral absorption, organism-specific biosystem (from KEGG)
      Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Mineral absorption, conserved biosystem (from KEGG)
      Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadmium ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    copper ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    cellular response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    negative regulation of growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    metallothionein-1B
    Names
    metallothionein-1B
    MT-1B
    MT-IB
    metallothionein 1Q
    metallothionein-IB
    metallothionein 1B (functional)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005947.2 → NP_005938.1  metallothionein-1B

      Status: PROVISIONAL

      Source sequence(s)
      AY168638
      Consensus CDS
      CCDS10765.1
      UniProtKB/Swiss-Prot
      P07438
      UniProtKB/TrEMBL
      Q86YX0
      Related
      ENSP00000334998, OTTHUMP00000164378, ENST00000334346, OTTHUMT00000257057

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      56685811..56687116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      42555257..42556561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026461.11 (34568..35873) None
    genomic AF350250.1 AAO49186.1
    genomic CH471092.1 EAW82880.1
    genomic M13484.1 AAA36331.1
    genomic M13485.1 AAA36331.1
    mRNA AF349000.2 AAO32960.2
    mRNA AY168638.1 AAN86984.1
    mRNA BC069421.1 AAH69421.1
    mRNA BC137478.1 AAI37479.1
    mRNA BC137479.1 AAI37480.1
    other-genetic EU832155.1 ACE87505.1
    other-genetic EU832249.1 ACE86819.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07438.1 GenPept UniProtKB/Swiss-Prot:P07438
    Q86YX0 GenPept UniProtKB/TrEMBL:Q86YX0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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