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    ph-d polyhomeotic distal [ Drosophila melanogaster ]

    Gene ID: 44889, updated on 10-May-2012
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    Summary

    Official Symbol
    ph-dprovided by Flybase
    Official Full Name
    polyhomeotic distalprovided by Flybase
    Primary source
    FLYBASE:FBgn0004860
    Locus tag
    Dmel_CG3895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3895; Dmel\CG3895; DROZFP; EG:BACN25G24.3; ph; Ph; PH; ph-D; PH-d; phd; PhD; PHD; phm; ph[d]; ph[D]
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    Genomic context

    Location :
    2D2-2D2; 1-0.5 cM
    Sequence :
    Chromosome: X; NC_004354.3 (2010899..2017164, complement)
    See ph-d in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene CG3981 gene product from transcript CG3981-RB Neighboring gene ncRNA Neighboring gene corkscrew Neighboring gene polyhomeotic proximal Neighboring gene CG3835 gene product from transcript CG3835-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila. Bantignies F, et al. Cell, 2011 Jan 21. PMID 21241892.
    2. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. Feng S, et al. EMBO Rep, 2011 Feb. PMID 21164514.
    3. Mutations in the polycomb group gene polyhomeotic lead to epithelial instability in both the ovary and wing imaginal disc in Drosophila. Gandille P, et al. PLoS One, 2010 Nov 11. PMID 21085656.
    4. A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. Saj A, et al. Dev Cell, 2010 May 18. PMID 20493818.
    5. Polycombing Drosophila for dynamic developmental footprints. Hill E. PLoS Biol, 2006 Jun. PMID 20076582.

    See all (190) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that cells in an epithelium expressing different levels of polyhomeotic sort out indicating differential adhesive properties between the cell populations.
      Title: Mutations in the polycomb group gene polyhomeotic lead to epithelial instability in both the ovary and wing imaginal disc in Drosophila.
    2. Ph SAM domain forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes
      Title: The SAM domain of polyhomeotic forms a helical polymer.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:69361 BioGRID:72482 CycK    BioGRID  PubMed Two-hybrid 
    BioGRID:69361 BioGRID:65606 Pc    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:69361 BioGRID:65403 ash1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:69361 BioGRID:65830 corto    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:69361 BioGRID:67682 hh    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:69361 BioGRID:62027 inv    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:69361 BioGRID:71800 l(3)73Ah    BioGRID  PubMed Two-hybrid 
    BioGRID:69361 BioGRID:57724 ph-p    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:69361 BioGRID:60626 salm    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:69361 BioGRID:66813 trx    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:69361 BioGRID:57802 w    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Homology

    • Homologs of the ph-d gene: The ph-d gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    chaperone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chromatin silencing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    PRC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PRC1 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG3895 gene product from transcript CG3895-RB
    Names
    CG3895-PA
    CG3895-PB
    ph-d-PA
    ph-d-PB
    polyhomeotic
    polyhomeotic distal
    polyhomeotic proximal
    polyhomeotic-distal
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      2010899..2017164, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103395.1 → NP_001096865.1  polyhomeotic distal, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NF31
      Related
      FBpp0111756, FBtr0112843
      Conserved Domains (2) summary
      cd09577
      Location:1283 – 1351
      Blast Score: 349
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      smart00454
      Location:1286 – 1351
      Blast Score: 165
      SAM; Sterile alpha motif.

    2. NM_080055.2 → NP_524794.2  polyhomeotic distal, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W523
      Related
      FBpp0070417, FBtr0070433
      Conserved Domains (2) summary
      cd09577
      Location:1461 – 1529
      Blast Score: 350
      SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
      smart00454
      Location:1464 – 1529
      Blast Score: 166
      SAM; Sterile alpha motif.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014298.4 ABW09326.1
    genomic AL132797.2 CAB60096.1
    genomic AE014298.4 AAF45726.3
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NF31.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content