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TLR2 toll like receptor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 448807, updated on 5-Mar-2024

Summary

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Official Symbol
TLR2provided by VGNC
Official Full Name
toll like receptor 2provided by VGNC
Primary source
VGNC:VGNC:59443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (52140775..52151566)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (51808717..51811083)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (51821784..51824151)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (51404786..51407152)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (51510608..51512974)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC119869313 Neighboring gene ring finger protein 175 Neighboring gene secreted frizzled related protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histopathological findings and detection of Toll-like receptor 2 in cutaneous lesions of canine leishmaniosis. Esteve LO, et al. Vet Parasitol, 2015 Apr 30. PMID 25825146
  2. The localization of Toll-like receptor 2 (TLR2) in the endometrium and the cervix of dogs at different stages of the oestrous cycle and with pyometra. Chotimanukul S, et al. Reprod Domest Anim, 2012 Dec. PMID 23279536
  3. Expression and function of Toll-like receptor 2 in canine blood phagocytes. Bazzocchi C, et al. Vet Immunol Immunopathol, 2005 Mar 10. PMID 15661327
  4. Expression of Toll-like receptors 2 and 9 in cells of dog jejunum and colon naturally infected with Leishmania infantum. Figueiredo MM, et al. BMC Immunol, 2013 May 14. PMID 23668673, Free PMC Article
  5. Toll receptors type-2 and CR3 expression of canine monocytes and its correlation with immunohistochemistry and xenodiagnosis in visceral leishmaniasis. Amorim IF, et al. PLoS One, 2011. PMID 22140456, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results obtained in this study indicated an association with TLR2 in the pathogenesis of canine cutaneous leishmaniosis.
    Title: Histopathological findings and detection of Toll-like receptor 2 in cutaneous lesions of canine leishmaniosis.
  2. These findings do not support a role for non-synonymous SNPs in the TLR 2, 4 and 9 coding regions in the pathogenesis of canine SNA, but do not exclude a role for innate immunity in the pathogenesis of the disease.
    Title: Assessment of Toll-like receptor 2, 4 and 9 SNP genotypes in canine sino-nasal aspergillosis.
  3. Study investigated the pattern of TLR-2, TLR-4 and TLR-9 gene expression in brain, choroid plexus, spleen and lymph node of dogs naturally infected with Leishmania infantum. In the brain, there was only an upregulation of TLR-2, in the choroid plexus, TLR-2 and TLR-9 were both upregulated and peripheral lymphoid organs showed increased TLR-2 and TLR-4 expression.
    Title: Compartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis.
  4. The aim of this study was to investigate the expression of TLR2 and TLR9 in jejunum and colon in dogs naturally infected with Leishmania infantum.
    Title: Expression of Toll-like receptors 2 and 9 in cells of dog jejunum and colon naturally infected with Leishmania infantum.
  5. This study provides the first report of immunohistochemical localization of TLR2 in the canine reproductive tract.
    Title: The localization of Toll-like receptor 2 (TLR2) in the endometrium and the cervix of dogs at different stages of the oestrous cycle and with pyometra.
  6. The aim of this study was to investigate the expression of TLR2 in peripheral blood monocytes cells of symptomatic dogs naturally infected with Leishmania (L.) infantum (syn: L. chagasi) [12] and its correlation with CR3 expression
    Title: Toll receptors type-2 and CR3 expression of canine monocytes and its correlation with immunohistochemistry and xenodiagnosis in visceral leishmaniasis.
  7. Synovial tissue specimens are obtained from both stifle joints dogs 12 weeks after surgery, and TLR-2 gene expression has been determined via real-time reverse transcription PCR assays.
    Title: Expression of Toll-like receptors 2 and 4 in stifle joint synovial tissues of dogs with or without osteoarthritis.
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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables triacyl lipopeptide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
toll-like receptor 2
NP_001005264.2
XP_038543100.1
XP_038543101.1
XP_038543102.1
XP_038543103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005264.3 → NP_001005264.2  toll-like receptor 2 precursor

    See identical proteins and their annotated locations for NP_001005264.2

    Status: PROVISIONAL

    Source sequence(s)
    EU487534
    UniProtKB/TrEMBL
    A0A8F0MPZ8, C0IRA0
    Conserved Domains (6) summary
    PRK15370
    Location:320 → 559
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:641 → 785
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:55 → 78
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:177 → 200
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:78 → 136
    LRR_8; Leucine rich repeat
    pfam13306
    Location:57 → 178
    LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    52140775..52151566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038687175.1 → XP_038543103.1  toll-like receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A6S4HU21, A0A8C0JM63, A0A8F0MPZ8
    Conserved Domains (6) summary
    PRK15370
    Location:335 → 587
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:641 → 785
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:55 → 78
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:177 → 200
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:58 → 279
    internalin_A; class 1 internalin InlA
    pfam13855
    Location:78 → 136
    LRR_8; Leucine rich repeat

  2. XM_038687172.1 → XP_038543100.1  toll-like receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8F0MPZ8
    Conserved Domains (6) summary
    PRK15370
    Location:352 → 604
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:658 → 802
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:72 → 95
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:194 → 217
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:75 → 296
    internalin_A; class 1 internalin InlA
    pfam13855
    Location:95 → 153
    LRR_8; Leucine rich repeat

  3. XM_038687173.1 → XP_038543101.1  toll-like receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A6S4HU21, A0A8C0JM63, A0A8F0MPZ8
    Conserved Domains (6) summary
    PRK15370
    Location:335 → 587
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:641 → 785
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:55 → 78
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:177 → 200
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:58 → 279
    internalin_A; class 1 internalin InlA
    pfam13855
    Location:78 → 136
    LRR_8; Leucine rich repeat

  4. XM_038687174.1 → XP_038543102.1  toll-like receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A6S4HU21, A0A8C0JM63, A0A8F0MPZ8
    Conserved Domains (6) summary
    PRK15370
    Location:335 → 587
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:641 → 785
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:55 → 78
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:177 → 200
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:58 → 279
    internalin_A; class 1 internalin InlA
    pfam13855
    Location:78 → 136
    LRR_8; Leucine rich repeat

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    51404786..51407152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    51510608..51512974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    51821784..51824151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    51808717..51811083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q689D1.1 GenPept UniProtKB/Swiss-Prot:Q689D1

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