MSN moesin [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: MSNprovided by HGNC
Official Full Name: moesinprovided by HGNC
Primary source: HGNC:7373
See related: Ensembl:ENSG00000147065; HPRD:02399; MIM:309845; Vega:OTTHUMG00000021723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: Xq11.1

Sequence :: Chromosome: X; NC_000023.10 (64887511..64961793)

See MSN in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The up-regulation of Ezrin and Moesin and the down-regulation of E-Cadherin were associated with the invasion and metastasis of papillary thyroid carcinoma.
Title: [Study of the correlation of papillary thyroid carcinoma's invasion with Ezrin, Moesin and E-Cadherin].
MSN was regulated by tumor suppressive miR-133a and contributed to HNSCC oncogenesis.
Title: Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.
The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers.
Title: Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
Knockdown of ERM family member moesin in host cells increases HIV type 1 replication.
Title: Knockdown of ERM family member moesin in host cells increases HIV type 1 replication.
Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.
Title: Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.
the ezrin, radixin and moesin proteins differentially modulate sphingosine 1 phosphate-induced alterations in lung endoethlial cell cytoskeleton and permeability
Title: Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.
This study provides the novel evidence that increased phosphorylation of Ezrin/radixin/moesin proteins may contribute to proliferation of rheumatoid fibroblast-like synoviocytes.
Title: Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes.
Dysregulation of the ezrin/radixin/moesin-RAGE complex might be an important step in rearrangement of the actin cytoskeleton during proinflammatory cytokine-induced epithelial-mesenchymal transition of human alveolar epithelial cells.
Title: Interplay between RAGE, CD44, and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells.
ezrin, radixin and moesin play similar roles in the tumor cell metastatic potential and their roles of upregulating the expression of E-cadherin may be important in tumor progression
Title: ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.
PDZD8 is a novel moesin-interacting protein that suppresses infection by herpes simplex virus type 1.
Title: PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1.

Submit: New GeneRIF Correction See all (45)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation	PubMed
	env	Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV	PubMed
Pr55(Gag)	gag	The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_002435.1	NP_036204.1	CD93	BIND	PubMed	Moesin interacts with CD93.
NP_002435.1	NP_004243.1	SLC9A3R1	BIND	PubMed	moesin interacts with hNHE-RF.
NP_002435.1	NP_003168.2	SYK	BIND	PubMed	Syk interacts with moesin. This interaction was modeled on a demonstrated interaction between Syk and moesin from unspecified species.
NP_002435.1	NP_000359.1	TSC1	BIND	PubMed	Hamartin interacts with moesin. This interaction was modeled on a demonstrated interaction between murine hamartin and human moesin.
P26038	P51572	BCAP31	HPRD	PubMed
P26038	P15529	CD46	HPRD	PubMed
P26038	Q9NPY3	CD93	HPRD	PubMed
P26038	P15311	EZR	HPRD	PubMed
P26038	P05362	ICAM1	HPRD	PubMed
P26038	P13598	ICAM2	HPRD	PubMed
P26038	P32942	ICAM3	HPRD	PubMed
P26038	P32004	L1CAM	HPRD	PubMed
P26038	P26038	MSN	HPRD	PubMed
P26038	P14598	NCF1	HPRD	PubMed
P26038	Q15080	NCF4	HPRD	PubMed
P26038	Q15149	PLEC	HPRD	PubMed
P26038	P35813	PPM1A	HPRD	PubMed
P26038	O75688	PPM1B	HPRD	PubMed
P26038	Q04759	PRKCQ	HPRD	PubMed
P26038	Q13464	ROCK1	HPRD	PubMed
P26038	P14151	SELL	HPRD	PubMed
P26038	Q14242	SELPLG	HPRD	PubMed
P26038	O14745	SLC9A3R1	HPRD	PubMed
P26038	P16150	SPN	HPRD	PubMed
P26038	Q92574	TSC1	HPRD	PubMed
P26038	P19320	VCAM1	HPRD	PubMed
BioGRID:110584	BioGRID:106889	ARHGDIA	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:107106	BID	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:107293	CASP10	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:107291	CASP8	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:107398	CD44	BioGRID	PubMed	Reconstituted Complex
BioGRID:110584	BioGRID:110346	CD46	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110584	BioGRID:113271	EZR	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Reconstituted Complex
BioGRID:110584	BioGRID:114302	FADD	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:106851	FAS	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:106852	FASLG	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110584	BioGRID:109351	HLA-B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110584	BioGRID:109611	ICAM2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110584	BioGRID:109612	ICAM3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110584	BioGRID:111585	MAPK8	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:110584	MSN	BioGRID	PubMed	Co-crystal Structure
BioGRID:110584	BioGRID:575724	NCF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110584	BioGRID:110769	NCF4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110584	BioGRID:106880	RHOA	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:112302	SELL	BioGRID	PubMed	Reconstituted Complex
BioGRID:110584	BioGRID:112304	SELPLG	BioGRID	PubMed	Reconstituted Complex
BioGRID:110584	BioGRID:114769	SLC9A3R1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110584	BioGRID:112571	SPN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110584	BioGRID:112587	SPTAN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110584	BioGRID:114323	TNFRSF10B	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:112986	TNFRSF1A	BioGRID	PubMed	Co-purification
BioGRID:110584	BioGRID:113099	TSC1	BioGRID	PubMed	Two-hybrid
BioGRID:110584	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110584	BioGRID:113255	VCAM1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
actin binding	IEA Inferred from Electronic Annotation more info
cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
receptor binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cellular component movement	TAS Traceable Author Statement more info	PubMed
leukocyte cell-cell adhesion	IEP Inferred from Expression Pattern more info	PubMed
leukocyte migration	IEP Inferred from Expression Pattern more info	PubMed
membrane to membrane docking	IEP Inferred from Expression Pattern more info	PubMed
regulation of lymphocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
apical part of cell	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	IEA Inferred from Electronic Annotation more info
basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
cell surface	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	TAS Traceable Author Statement more info	PubMed
extrinsic to membrane	IEA Inferred from Electronic Annotation more info
filopodium	IDA Inferred from Direct Assay more info	PubMed
filopodium membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info
internal side of plasma membrane	IEA Inferred from Electronic Annotation more info
microvillus	IDA Inferred from Direct Assay more info	PubMed
microvillus membrane	IEA Inferred from Electronic Annotation more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
secretory granule membrane	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info
uropod	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: moesin

Names: moesin; membrane-organizing extension spike protein

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012516.1 RefSeqGene

Range

5001..79283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002444.2 → NP_002435.1 moesin

Status: REVIEWED

Source sequence(s)

BC017293, CN386296, M69066

Consensus CDS

CCDS14382.1

UniProtKB/Swiss-Prot

P26038

Related

ENSP00000353408, OTTHUMP00000023438, ENST00000360270, OTTHUMT00000056981

Conserved Domains (5) summary

pfam00769
Location:353 – 577
Blast Score: 462

ERM; Ezrin/radixin/moesin family

cd00836
Location:200 – 292
Blast Score: 317

FERM_C; FERM_C domain

smart00295
Location:7 – 206
Blast Score: 493

B41; Band 4.1 homologues

pfam00373
Location:93 – 206
Blast Score: 307

FERM_M; FERM central domain

pfam09379
Location:9 – 86
Blast Score: 230

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

64887511..64961793

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

58715854..58790104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	CH471132.2	EAX05398.1
		EAX05399.1
genomic	Z98946.15	CAB46379.1
mRNA	AK297165.1	BAH12513.1
mRNA	AK308486.1	None
mRNA	AK309986.1	None
mRNA	BC001112.2	AAH01112.1
mRNA	BC011827.2	AAH11827.1
mRNA	BC017293.2	AAH17293.1
mRNA	CN386296.1	None
mRNA	M69066.1	AAA36322.1
other-genetic	DQ892653.2	ABM83579.1
other-genetic	DQ895892.2	ABM86818.1