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atp2a2.S ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 446229, updated on 11-Apr-2024

Summary

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Official Symbol
atp2a2.S
Official Full Name
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 S homeolog
Primary source
Xenbase:XB-GENE-1012936
Locus tag
XELAEV_18010651mg
See related
EnsemblRapid:ENSXLAG00005008432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dar; atp2a; atp2b; atp2a1; atp2a2; serca1; serca2
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Genomic context

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Location:
chromosome: 1S
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (150900976..150932330)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (135122920..135154414)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 S homeolog Neighboring gene uncharacterized LOC121399497 Neighboring gene anaphase promoting complex subunit 7 S homeolog Neighboring gene actin related protein 2/3 complex subunit 3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-specific expression of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (ATP2A/SERCA) 1, 2, 3 during Xenopus laevis development. Pegoraro C, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 21074636
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atp2a1/serca1 is expressed as soon as the end of gastrulation in a subset of the myod-positive cells, and later labels prospective slow muscle cells in the superficial part of the somite.
    Title: Tissue-specific expression of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (ATP2A/SERCA) 1, 2, 3 during Xenopus laevis development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cardiac muscle contraction by calcium ion signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATPase, Ca++ transporting, slow twitch 2
Names
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
NP_001086443.1
XP_041431430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001092974.1 → NP_001086443.1  ATPase, Ca++ transporting, slow twitch 2

    See identical proteins and their annotated locations for NP_001086443.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133185
    UniProtKB/TrEMBL
    A0A974I1Y9, A0A974I4U1, A2RV57
    Related
    ENSXLAP00005024360.1, ENSXLAT00005025067.1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 988
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:783 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:605 → 711
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 527
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    150900976..150932330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041575496.1 → XP_041431430.1  ATPase, Ca++ transporting, slow twitch 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LRS3, A0A974I4U1
    Related
    ENSXLAP00005024390.1, ENSXLAT00005025098.1
    Conserved Domains (1) summary
    cd02083
    Location:5 → 988
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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