IKKbeta I-kappaB kinase beta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: IKKbetaprovided by FlyBase
Official Full Name: I-kappaB kinase betaprovided by FlyBase
Primary source: FLYBASE:FBgn0024222
Locus tag: Dmel_CG4201
See related: AllianceGenome:FB:FBgn0024222
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-89Bd; CG4201; DIK; dIKK; dIKK-beta; dIKKbeta; dLak; DLAK; Dmel\CG4201; DmIKK; Dmikkb; DmIKKb; dmIKKbeta; Dmikkbeta; DmIkkbeta; DmIKKbeta; DmIKKBeta; Ik; IK; ikk; IKK; IKK-beta; Ikkb; IKKb; IKKB; Ikkbeta; IKKBeta; ird; ird-5; Ird-5; IRD-5; ird5; Ird5; IRD5; ird5/DmIkk[beta]; ird[5]; Lak; LRK
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including defense response to other organism; positive regulation of NIK/NF-kappaB signaling; and regulation of defense response. Located in cytoplasm. Is expressed in several structures, including adult Malpighian tubule; fat body/gonad primordium; germline cell; and gonad. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); fetal encasement syndrome; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex) and IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 89B1-89B1; 3-58 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16046347..16049421, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11872069..11875143, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of kinase IKKbeta suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.
Title: Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGAS/STING signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of antibacterial peptide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: I-kappaB kinase beta

Names: CG4201-PB; IKK-like protein; IKKbeta-PB; LPS-responsive kinase; LPS-responsive-kinase; cactus kinase; immune response deficient 5; immune response-deficient 5; lipopolysaccharide activated kinase; mmune response deficient 5

NP_524751.3

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16046347..16049421 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080012.4 → NP_524751.3 I-kappaB kinase beta [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524751.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GYV6, Q9NJI1, Q9U698, Q9U7F5, Q9VEZ5

Conserved Domains (2) summary

smart00220
Location:7 → 245

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:13 → 316

PKc_like; Protein Kinases, catalytic domain