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ASPH aspartate beta-hydroxylase [ Homo sapiens (human) ]

Gene ID: 444, updated on 23-Sep-2014
Official Symbol
ASPHprovided by HGNC
Official Full Name
aspartate beta-hydroxylaseprovided by HGNC
Primary source
HGNC:HGNC:757
See related
Ensembl:ENSG00000198363; HPRD:08996; MIM:600582; Vega:OTTHUMG00000164375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAH; BAH; HAAH; JCTN; FDLAB; junctin; CASQ2BP1
Summary
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
See ASPH in Epigenomics, MapViewer
Location:
8q12.1
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (61500556..61714640, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (62413115..62627199, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 6 Neighboring gene uncharacterized LOC101929593 Neighboring gene clavesin 1 Neighboring gene keratin 8 pseudogene 3 Neighboring gene microRNA 4470 Neighboring gene uncharacterized LOC101929610

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
electron carrier activity TAS
Traceable Author Statement
more info
PubMed 
ion channel binding TAS
Traceable Author Statement
more info
PubMed 
peptide-aspartate beta-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of store-operated calcium channel activity IDA
Inferred from Direct Assay
more info
 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
 
detection of calcium ion TAS
Traceable Author Statement
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
palate development IEA
Inferred from Electronic Annotation
more info
 
pattern specification process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-aspartic acid hydroxylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
 
positive regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ryanodine-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
Traceable Author Statement
more info
 
regulation of cell communication by electrical coupling TAS
Traceable Author Statement
more info
 
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
 
regulation of protein depolymerization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
regulation of ryanodine-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
 
response to ATP IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
calcium channel complex TAS
Traceable Author Statement
more info
PubMed 
cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
junctional sarcoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
sarcoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
aspartyl/asparaginyl beta-hydroxylase
Names
aspartyl/asparaginyl beta-hydroxylase
humbug
junctate
A beta H-J-J
cardiac junctin
ASP beta-hydroxylase
peptide-aspartate beta-dioxygenase
aspartyl/asparaginyl-beta-hydroxylase
NP_001158222.1
NP_001158223.1
NP_001158224.1
NP_001158225.1
NP_001158226.1
NP_001158227.1
NP_001158228.1
NP_004309.2
NP_064549.1
NP_115855.1
NP_115856.1
NP_115857.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013210.1 

    Range
    5001..219085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164750.1NP_001158222.1  aspartyl/asparaginyl beta-hydroxylase isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus, compared to isoform a. This isoform includes the beta-hydroxylase domain found in isoform a and is likely to have catalytic activity.
    Source sequence(s)
    AC090094, AF339775, AK304314, BC025236, DN993915, S83325
    Consensus CDS
    CCDS55234.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000437864, ENST00000541428
    Conserved Domains (5) summary
    TIGR02795
    Location:313426
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14281
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:414487
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:560717
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:316355
    TPR_14; Tetratricopeptide repeat
  2. NM_001164751.1NP_001158223.1  aspartyl/asparaginyl beta-hydroxylase isoform g

    See proteins identical to NP_001158223.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, uses a distinct 3' splice pattern that lacks many coding exons, includes an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (g) has a shorter and distinct N-terminus a substantially shorter and distinct C-terminus, and several internal differences, compared to isoform a. This isoform is similar to isoform b, which is also known as junctate.
    Source sequence(s)
    AC067881, BC144362, BU623111, DN993915
    Consensus CDS
    CCDS55236.1
    UniProtKB/Swiss-Prot
    Q12797
    Conserved Domains (1) summary
    pfam05279
    Location:14295
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  3. NM_001164752.1NP_001158224.1  aspartyl/asparaginyl beta-hydroxylase isoform h

    See proteins identical to NP_001158224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, uses a distinct 3' splice pattern that lacks many coding exons, includes an alternate in-frame exon, lacks an alternate in-frame exon, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (h) has a shorter and distinct N-terminus a substantially shorter and distinct C-terminus, and several internal differences, compared to isoform a. This isoform is similar to isoform b, which is also known as junctate.
    Source sequence(s)
    AC067881, BC144363, BU623111, DN993915
    UniProtKB/TrEMBL
    B7ZM96
    Conserved Domains (1) summary
    pfam05279
    Location:14276
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  4. NM_001164753.1NP_001158225.1  aspartyl/asparaginyl beta-hydroxylase isoform i

    See proteins identical to NP_001158225.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter and 5' UTR and uses a distinct start codon, uses a distinct 3' splice pattern that lacks many coding exons, includes an alternate in-frame exon, and lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (i) has a shorter and distinct N-terminus a substantially shorter and distinct C-terminus, and several internal differences, compared to isoform a. This isoform is similar to isoform b, which is also known as junctate.
    Source sequence(s)
    AC067881, AK295528, BU623111, DN993915
    Consensus CDS
    CCDS55235.1
    UniProtKB/Swiss-Prot
    Q12797
    Conserved Domains (1) summary
    pfam05279
    Location:14253
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  5. NM_001164754.1NP_001158226.1  aspartyl/asparaginyl beta-hydroxylase isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The resulting isoform (j) lacks an internal segment and has a substantially shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC067881, AK298577, BU623111, DA136318
    Consensus CDS
    CCDS75746.1
    UniProtKB/TrEMBL
    B4DQ07
    Related
    ENSP00000394013, ENST00000445642
    Conserved Domains (1) summary
    pfam05279
    Location:43291
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  6. NM_001164755.1NP_001158227.1  aspartyl/asparaginyl beta-hydroxylase isoform k

    See proteins identical to NP_001158227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an alternate in-frame exon and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The resulting isoform (k) lacks an internal segment and has a substantially shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC067881, BC025236, BU623111
    Consensus CDS
    CCDS55237.1
    UniProtKB/Swiss-Prot
    Q12797
    Conserved Domains (1) summary
    pfam05279
    Location:43267
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  7. NM_001164756.1NP_001158228.1  aspartyl/asparaginyl beta-hydroxylase isoform l

    See proteins identical to NP_001158228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) includes an alternate in-frame exon and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The resulting isoform (l) includes an alternate segment and has a substantially shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC066929, BU741737, CR996516, DA136318
    Consensus CDS
    CCDS55238.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000368762, OTTHUMP00000226619, ENST00000379449, OTTHUMT00000378583
    Conserved Domains (1) summary
    pfam05279
    Location:43146
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  8. NM_004318.3NP_004309.2  aspartyl/asparaginyl beta-hydroxylase isoform a

    See proteins identical to NP_004309.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. The distinct C-terminus of this isoform has enzymatic activity which hydroxylates the beta carbon of aspartic acid or asparagine residues in certain epidermal growth factor-like domains of proteins such as protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. This variant is widely expressed among heart, placenta, skeletal muscle, kidney, and lung tissues.
    Source sequence(s)
    AC067881, AC090094, S83325, U03109
    Consensus CDS
    CCDS34898.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000368767, OTTHUMP00000226573, ENST00000379454, OTTHUMT00000378510
    Conserved Domains (4) summary
    TIGR02795
    Location:342455
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43310
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:443516
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:589746
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  9. NM_020164.4NP_064549.1  aspartyl/asparaginyl beta-hydroxylase isoform e

    See proteins identical to NP_064549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, includes an alternate in-frame exon, and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (e) has a slightly shorter and distinct N-terminus and some overlap with the N-terminus of isoform a. This isoform lacks the catalytic domain and enzymatic function of isoform a. This isoform has also been referred to as junctin isoform 1 and forms a complex with calsequestrin, triadin, and the ryanodine receptor by direct interaction at the C-terminal part of the molecule. This protein appears to stabilize the complex and plays a crucial role in the regulation of calcium release from the sarcoplasmic reticulum. This variant is expressed in cardiac and skeletal muscle.
    Source sequence(s)
    AC067881, AF224469, BX102882, DN993915
    Consensus CDS
    CCDS34900.1
    UniProtKB/Swiss-Prot
    Q12797
    Conserved Domains (1) summary
    pfam05279
    Location:14205
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  10. NM_032466.3NP_115855.1  aspartyl/asparaginyl beta-hydroxylase isoform c

    See proteins identical to NP_115855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (c), also known as humbug, is identical to the N-terminal and central region of isoform a. Because this transcript variant lacks the alternative 3' terminal exon which encodes a catalytic domain for isoform a, isoform c is considered a noncatalytic isoform. This variant is widely expressed among heart, placenta, skeletal muscle, kidney, and lung tissues.
    Source sequence(s)
    AC067881, AF289489, BC025236, BU623111
    Consensus CDS
    CCDS43742.1
    UniProtKB/Swiss-Prot
    Q12797
    Related
    ENSP00000348841, OTTHUMP00000226574, ENST00000356457, OTTHUMT00000378511
    Conserved Domains (1) summary
    pfam05279
    Location:43310
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  11. NM_032467.3NP_115856.1  aspartyl/asparaginyl beta-hydroxylase isoform d

    See proteins identical to NP_115856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (d) has a slightly shorter and distinct N-terminus and some overlap with the N-terminus of isoform a, but lacks the catalytic domain and enzymatic function of isoform a. This isoform has also been referred to as junctin and forms a complex with calsequestrin, triadin, and the ryanodine receptor by direct interaction at the C-terminal part of the molecule. This protein appears to stabilize the complex and plays a crucial role in the regulation of calcium release from the sarcoplasmic reticulum. This variant is expressed in cardiac and skeletal muscle.
    Source sequence(s)
    AC067881, AF224468, BX102882, DN993915
    Consensus CDS
    CCDS34899.1
    UniProtKB/Swiss-Prot
    Q12797
    Conserved Domains (1) summary
    pfam05279
    Location:14190
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  12. NM_032468.4NP_115857.1  aspartyl/asparaginyl beta-hydroxylase isoform b

    See proteins identical to NP_115857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, includes an alternate in-frame exon, and uses a distinct 3' splice pattern that lacks many coding exons, compared to variant 1. The encoded isoform (b) shares residues with the central region of isoform a. This isoform lacks the catalytic domain and enzymatic function of isoform a. Isoform b has also been referred to as junctate and is located in both the endoplasmic and sarcoplasmic reticulum. Calcium binding properties of this isoform suggest an active role in the calcium storage and release process in the endoplasmic reticulum. This variant is expressed in heart, brain, pancreas, placenta, lung, liver, kidney, and skeletal muscle tissues.
    Source sequence(s)
    AC067881, AF306765, BU623111, DN993915
    Consensus CDS
    CCDS47866.1
    UniProtKB/Swiss-Prot
    Q12797
    Conserved Domains (1) summary
    pfam05279
    Location:14296
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    61500556..61714640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251247.1XP_005251304.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:295408
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43263
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:396469
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:542699
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  2. XM_005251243.1XP_005251300.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:314427
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43282
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:415488
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:561718
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  3. XM_005251239.1XP_005251296.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:338451
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43306
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:439512
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:585742
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  4. XM_005251236.1XP_005251293.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:356469
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43324
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:457530
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:603760
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  5. XM_005251238.1XP_005251295.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:342455
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43322
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:443516
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:589746
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  6. XM_005251235.1XP_005251292.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:357470
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43325
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:458531
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:604761
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  7. XM_005251250.1XP_005251307.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:280393
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43248
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:381454
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:527684
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  8. XM_005251246.1XP_005251303.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:299412
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43267
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:400473
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:546703
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  9. XM_005251242.1XP_005251299.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:323436
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:43291
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:424497
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:570727
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  10. XM_006716448.1XP_006716511.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:299412
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:1267
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:400473
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:546703
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  11. XM_005251249.1XP_005251306.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:285398
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14253
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:386459
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:532689
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  12. XM_005251244.1XP_005251301.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:308421
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14276
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:409482
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:555712
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  13. XM_005251241.1XP_005251298.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:327440
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14295
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:428501
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:574731
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  14. XM_005251240.1XP_005251297.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:328441
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14296
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:429502
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:575732
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  15. XM_005251248.1XP_005251305.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:294407
    tol_pal_ybgF; tol-pal system protein YbgF
    pfam05279
    Location:14262
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd00189
    Location:395468
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:541698
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
  16. XM_006716449.1XP_006716512.1  

    Conserved Domains (4) summary
    TIGR02795
    Location:147260
    tol_pal_ybgF; tol-pal system protein YbgF
    cd00189
    Location:248321
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam05118
    Location:394551
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:150189
    TPR_14; Tetratricopeptide repeat

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    57901587..58116117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    62465102..62679146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)