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CXCL8 C-X-C motif chemokine ligand 8 [ Ovis aries (sheep) ]

Gene ID: 443418, updated on 5-Mar-2024

Summary

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Gene symbol
CXCL8
Gene description
C-X-C motif chemokine ligand 8
See related
EnsemblRapid:ENSOARG00020002886
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
IL8
Orthologs
human all
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Genomic context

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Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 6 NC_056059.1 (89554539..89558016)

Chromosome 6 - NC_056059.1Genomic Context describing neighboring genes Neighboring gene alpha-fetoprotein-like Neighboring gene Ras association domain family member 6 Neighboring gene uncharacterized LOC121819874 Neighboring gene uncharacterized LOC121819876 Neighboring gene uncharacterized LOC121819875 Neighboring gene C-X-C motif chemokine 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056059.1 Chromosome 6 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung. Kallapur SG, et al. Am J Physiol Lung Cell Mol Physiol, 2009 Sep. PMID 19574422, Free PMC Article
  2. Cloning, sequencing, expression and inflammatory activity in skin of ovine interleukin-8. Seow HF, et al. Immunol Cell Biol, 1994 Oct. PMID 7835984
  3. Sequencing of the ovine interleukin-8-encoding cDNA using the polymerase chain reaction. Legastelois I, et al. Gene, 1994 Dec 15. PMID 7821808
  4. Late production of CXCL8 in ruminant oro-nasal turbinate cells in response to Chlamydia abortus infection. Doull L, et al. Vet Immunol Immunopathol, 2015 Nov 15. PMID 26342452

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.
    Title: Late production of CXCL8 in ruminant oro-nasal turbinate cells in response to Chlamydia abortus infection.
  2. IL-8 signaling does not mediate lipopolysaccharide-induced lung inflammation and lung maturation.
    Title: IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chemokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-8
Names
C-X-C motif chemokine 8
IL-8
chemokine (C-X-C motif) ligand 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009401.2 → NP_001009401.1  interleukin-8 precursor

    See identical proteins and their annotated locations for NP_001009401.1

    Status: PROVISIONAL

    Source sequence(s)
    X78306
    UniProtKB/Swiss-Prot
    P36925
    UniProtKB/TrEMBL
    A0A836D4N9, S5TPE2
    Related
    ENSOARP00020003646.1, ENSOART00020004439.2
    Conserved Domains (1) summary
    cd00273
    Location:31 → 94
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056059.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    89554539..89558016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36925.1 GenPept UniProtKB/Swiss-Prot:P36925

Gene LinkOut

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