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MYO1B myosin IB [ Homo sapiens (human) ]

Gene ID: 4430, updated on 26-May-2016
Official Symbol
MYO1Bprovided by HGNC
Official Full Name
myosin IBprovided by HGNC
Primary source
HGNC:HGNC:7596
See related
Ensembl:ENSG00000128641 HPRD:08407; MIM:606537; Vega:OTTHUMG00000132718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
myr1
Orthologs
Location:
2q12-q34
Exon count:
34
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (191245185..191425389)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192110107..192290115)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene uncharacterized LOC105373804 Neighboring gene high mobility group box 1 pseudogene 27 Neighboring gene uncharacterized LOC105373803 Neighboring gene uncharacterized LOC105373807 Neighboring gene uncharacterized LOC105373809 Neighboring gene uncharacterized LOC105373808

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin-dependent ATPase activity IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microfilament motor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament-based movement ISS
Inferred from Sequence or Structural Similarity
more info
 
post-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
brush border ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
unconventional myosin-Ib
Names
MMI-alpha
MMIa
MYH-1c
MYO1B variant protein
myosin I alpha
myosin-I alpha
myosin-Ib

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130158.1NP_001123630.1  unconventional myosin-Ib isoform 1

    See identical proteins and their annotated locations for NP_001123630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AB290176, AI751497, AJ001381, BC060849, BF061446, CA435949, DB461518
    Consensus CDS
    CCDS46477.1
    UniProtKB/Swiss-Prot
    O43795
    UniProtKB/TrEMBL
    B0I1S9
    Related
    ENSP00000376132, OTTHUMP00000205475, ENST00000392318, OTTHUMT00000334774
    Conserved Domains (3) summary
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9401136
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
  2. NM_001161819.1NP_001155291.1  unconventional myosin-Ib isoform 1

    See identical proteins and their annotated locations for NP_001155291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AB290176, AI751497, AJ001381, BC053558, BF061446, BQ027157, CN295039
    Consensus CDS
    CCDS46477.1
    UniProtKB/Swiss-Prot
    O43795
    UniProtKB/TrEMBL
    B0I1S9
    Related
    ENSP00000306382, OTTHUMP00000163591, ENST00000304164, OTTHUMT00000256057
    Conserved Domains (3) summary
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9401136
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
  3. NM_012223.3NP_036355.2  unconventional myosin-Ib isoform 2

    See identical proteins and their annotated locations for NP_036355.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two coding exons in the 3' region, as compared to variant 1. The reading frame is not affected, so the resulting isoform (2) is shorter but has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AB290176, AI751497, AJ001381, BC060849, BF061446, CA435949, DB461518
    Consensus CDS
    CCDS2311.1
    UniProtKB/Swiss-Prot
    O43795
    UniProtKB/TrEMBL
    B0I1S9
    Related
    ENSP00000341903, OTTHUMP00000163592, ENST00000339514, OTTHUMT00000256058
    Conserved Domains (4) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:8821078
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    191245185..191425389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511213.1XP_011509515.1  

    See identical proteins and their annotated locations for XP_011509515.1

    UniProtKB/Swiss-Prot
    O43795
    UniProtKB/TrEMBL
    B0I1S9
    Conserved Domains (3) summary
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9401136
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
  2. XM_006712536.1XP_006712599.1  

    See identical proteins and their annotated locations for XP_006712599.1

    UniProtKB/Swiss-Prot
    O43795
    UniProtKB/TrEMBL
    B0I1S9
    Conserved Domains (3) summary
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9401136
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
  3. XM_005246572.1XP_005246629.1  

    See identical proteins and their annotated locations for XP_005246629.1

    UniProtKB/Swiss-Prot
    O43795
    UniProtKB/TrEMBL
    B0I1S9
    Conserved Domains (3) summary
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9401136
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
  4. XM_011511215.1XP_011509517.1  

    See identical proteins and their annotated locations for XP_011509517.1

    Conserved Domains (4) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9111107
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
  5. XM_011511214.1XP_011509516.1  

    See identical proteins and their annotated locations for XP_011509516.1

    UniProtKB/TrEMBL
    E9PDF6
    Related
    ENSP00000376130, OTTHUMP00000165861, ENST00000392316, OTTHUMT00000259028
    Conserved Domains (4) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    pfam06017
    Location:9111107
    Myosin_TH1; Myosin tail
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    192115938..192295960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)