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    MYO1B myosin IB [ Homo sapiens ]

    Gene ID: 4430, updated on 11-May-2012
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    Summary

    Official Symbol
    MYO1Bprovided by HGNC
    Official Full Name
    myosin IBprovided by HGNC
    Primary source
    HGNC:7596
    See related
    Ensembl:ENSG00000128641; HPRD:08407; MIM:606537; Vega:OTTHUMG00000132718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    myr1
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    Genomic context

    Location :
    2q12-q34
    Sequence :
    Chromosome: 2; NC_000002.11 (192110107..192290115)
    See MYO1B in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene high mobility group box 1 pseudogene 27 Neighboring gene oligonucleotide/oligosaccharide-binding fold containing 2A Neighboring gene serum deprivation response

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network. Almeida CG, et al. Nat Cell Biol, 2011 Jun 12. PMID 21666684.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Myosin I can act as a molecular force sensor. Laakso JM, et al. Science, 2008 Jul 4. PMID 18599791.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Actin and myosin 1 regulate organelle shape and uncover an important function for myosin 1b in the initiation of post-Golgi carrier formation by regulating actin assembly and remodelling trans-Golgi network membranes.
      Title: Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network.
    2. Sensing molecular tension is crucial for a wide array of cellular processes. Myosin I dramatically alters its motile properties in response to tension.
      Title: Myosin I can act as a molecular force sensor.
    3. At apical surfaces of supporting cells that surround hair cells in auditory epithelia of postnatal rats. In vestibular epithelia, present in ring within apical pole of hair cell. Expression was prominent only immediately after birth.
      Title: Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.
    4. observations suggest that myosin 1b controls the traffic of protein cargo in multivesicular endosomes most probably through its ability to modulate with actin the morphology of these sorting endosomes
      Title: Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:110567 BioGRID:120578 BRF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110567 BioGRID:108290 EIF4A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110567 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110567 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    actin filament-based movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    brush border ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    unconventional myosin-Ib
    Names
    unconventional myosin-Ib
    MMIa
    MYH-1c
    MMI-alpha
    myosin-Ib
    myosin I alpha
    myosin-I alpha
    MYO1B variant protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130158.1 → NP_001123630.1  unconventional myosin-Ib isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same iosform (1).
      Source sequence(s)
      AB290176, AI751497, AJ001381, BC060849, BF061446, CA435949, DB461518
      Consensus CDS
      CCDS46477.1
      UniProtKB/TrEMBL
      B0I1S9
      UniProtKB/Swiss-Prot
      O43795
      Related
      ENSP00000376132, OTTHUMP00000205475, ENST00000392318, OTTHUMT00000334774
      Conserved Domains (3) summary
      cd01378
      Location:16 – 700
      Blast Score: 2463
      MYSc_type_I; Myosin motor domain, type I myosins. Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. This ...
      pfam06017
      Location:940 – 1136
      Blast Score: 405
      Myosin_TH1; Myosin tail
      smart00242
      Location:16 – 701
      Blast Score: 2523
      MYSc; Myosin. Large ATPases.

    2. NM_001161819.1 → NP_001155291.1  unconventional myosin-Ib isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same iosform (1).
      Source sequence(s)
      AB290176, AI751497, AJ001381, BC053558, BF061446, BQ027157, CN295039
      Consensus CDS
      CCDS46477.1
      UniProtKB/TrEMBL
      B0I1S9
      UniProtKB/Swiss-Prot
      O43795
      Related
      ENSP00000306382, OTTHUMP00000163591, ENST00000304164, OTTHUMT00000256057
      Conserved Domains (3) summary
      cd01378
      Location:16 – 700
      Blast Score: 2463
      MYSc_type_I; Myosin motor domain, type I myosins. Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. This ...
      pfam06017
      Location:940 – 1136
      Blast Score: 405
      Myosin_TH1; Myosin tail
      smart00242
      Location:16 – 701
      Blast Score: 2523
      MYSc; Myosin. Large ATPases.

    3. NM_012223.3 → NP_036355.2  unconventional myosin-Ib isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two coding exons in the 3' region, as compared to variant 1. The reading frame is not affected, so the resulting isoform (2) is shorter but has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AB290176, AI751497, AJ001381, BC060849, BF061446, CA435949, DB461518
      Consensus CDS
      CCDS2311.1
      UniProtKB/TrEMBL
      B0I1S9
      UniProtKB/Swiss-Prot
      O43795
      Related
      ENSP00000341903, OTTHUMP00000163592, ENST00000339514, OTTHUMT00000256058
      Conserved Domains (3) summary
      cd01378
      Location:16 – 700
      Blast Score: 2455
      MYSc_type_I; Myosin motor domain, type I myosins. Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. This ...
      pfam06017
      Location:882 – 1078
      Blast Score: 403
      Myosin_TH1; Myosin tail
      smart00242
      Location:16 – 701
      Blast Score: 2514
      MYSc; Myosin. Large ATPases.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      192110107..192290115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      183969542..184149826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC068056.7 (119248..193016) None
    genomic AC092614.2 (39076..106991) None
    genomic AC118061.4 (2000..17359) None
    genomic AC133534.2 None
    genomic CH471058.2 EAX10839.1
      EAX10840.1
      EAX10841.1
      EAX10842.1
      EAX10843.1
      EAX10844.1
      EAX10845.1
    mRNA AB290176.1 BAG06730.1
    mRNA AI751497.1 None
    mRNA AJ001381.1 CAA04712.1
    mRNA AJ001382.1 CAA04713.1
    mRNA AK000160.1 None
    mRNA AK022489.1 None
    mRNA AK074978.1 BAG52044.1
    mRNA BC021665.1 AAH21665.1
    mRNA BC053558.1 AAH53558.1
    mRNA BC060849.1 None
    mRNA BF061446.1 None
    mRNA BG563224.1 None
    mRNA BQ027157.1 None
    mRNA BQ650834.1 None
    mRNA CA435949.1 None
    mRNA CN295039.1 None
    mRNA DB461518.1 None
    mRNA L29138.1 AAA20901.1
    other-genetic EU832107.1 ACE87457.1
    other-genetic EU832201.1 ACE86771.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43795.3 GenPept UniProtKB/Swiss-Prot:O43795
    Q05CR5 GenPept UniProtKB/TrEMBL:Q05CR5
    Q14777 GenPept UniProtKB/TrEMBL:Q14777
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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