trbl tribbles [Drosophila melanogaster] - Gene

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Summary

Official Symbol: trblprovided by Flybase
Official Full Name: tribblesprovided by Flybase
Primary source: FLYBASE:FBgn0028978
Locus tag: Dmel_CG5408
Gene type: protein coding
RNA name: tribbles
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5408; Dmel\CG5408; trb

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Genomic context

Location :: 77C1-77C1

Sequence :: Chromosome: 3L; NT_037436.3 (20389388..20394708, complement)

See trbl in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SKIP3, an ortholog of this protein, is overexpressed in human tumors and is regulated by hypoxia.
Title: SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:68764	BioGRID:67718	CG10164	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:58852	CG12708	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:57972	CG12730	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:65241	CG6333	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:61346	CG8679	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:68764	BioGRID:60798	Hsp60D	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:64110	Myt1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:68764	BioGRID:57823	N	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:68764	BioGRID:67224	WRNexo	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:59332	cactin	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:60000	eIF-4a	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:65288	mus304	BioGRID	PubMed	Two-hybrid
BioGRID:68764	BioGRID:63463	slbo	BioGRID	PubMed	Phenotypic Suppression
BioGRID:68764	BioGRID:68333	stg	BioGRID	PubMed	Phenotypic Suppression
BioGRID:68764	BioGRID:60116	wee	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:68764	BioGRID:61926	whd	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the trbl gene: The trbl gene is conserved in human, chimpanzee, dog, cow, mouse, chicken, and zebrafish.

Pathways from BioSystems

Activation of PKB, organism-specific biosystem (from REACTOME)
Activation of PKB, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CD28 co-stimulation, organism-specific biosystem (from REACTOME)
CD28 co-stimulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
CD28 dependent PI3K/Akt signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events, organism-specific biosystem (from REACTOME)
IRS-related events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI-3K cascade, organism-specific biosystem (from REACTOME)
PI-3K cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K Cascade, organism-specific biosystem (from REACTOME)
PI3K Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
gastrulation	NAS Non-traceable Author Statement more info	PubMed
negative regulation of mitosis	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
ventral furrow formation	IGI Inferred from Genetic Interaction more info	PubMed

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General protein information

Preferred Names: CG5408 gene product from transcript CG5408-RA

Names: CG5408-PA; trbl-PA; tribbles

NP_524672.1

EC 2.7.11.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

20389388..20394708, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079933.3 → NP_524672.1 tribbles [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9V3Z1

Related

FBpp0077893, FBtr0078235

Conserved Domains (2) summary

smart00220
Location:141 – 397
Blast Score: 308

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:226 – 388
Blast Score: 253

PKc_like; Protein Kinases, catalytic domain