Display Settings:

Format

Send to:

Choose Destination

ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) [ Homo sapiens (human) ]

Gene ID: 439, updated on 7-Dec-2014
Official Symbol
ASNA1provided by HGNC
Official Full Name
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)provided by HGNC
Primary source
HGNC:HGNC:752
See related
Ensembl:ENSG00000198356; HPRD:03555; MIM:601913; Vega:OTTHUMG00000180355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GET3; ARSA1; TRC40; ARSA-I; ASNA-I; hASNA-I
Summary
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
See ASNA1 in Epigenomics, MapViewer
Location:
19q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (12737492..12748323)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12848306..12859137)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene chromosome 19 open reading frame 43 Neighboring gene bestrophin 2 Neighboring gene hook microtubule-tethering protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of arsA arsenite transporter, ATP-binding, homolog 1 (ASNA1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC3821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
arsenite transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ATP catabolic process IEA
Inferred from Electronic Annotation
more info
 
inorganic anion transport TAS
Traceable Author Statement
more info
PubMed 
protein insertion into ER membrane IEA
Inferred from Electronic Annotation
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
ATPase ASNA1
Names
ATPase ASNA1
ASNA1
golgi to ER traffic 3 homolog
transmembrane domain recognition complex, 40kDa
transmembrane domain recognition complex 40 kDa ATPase subunit
NP_004308.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004317.2NP_004308.2  ATPase ASNA1

    See proteins identical to NP_004308.2

    Status: VALIDATED

    Source sequence(s)
    BC002651, BG426136
    Consensus CDS
    CCDS32920.1
    UniProtKB/Swiss-Prot
    O43681
    Related
    ENSP00000349887, ENST00000357332
    Conserved Domains (2) summary
    cd02035
    Location:53318
    ArsA; ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces ...
    pfam02374
    Location:37340
    ArsA_ATPase; Anion-transporting ATPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    12737492..12748323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    12848768..12859600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    12421428..12432073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)