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    CycG Cyclin G [ Drosophila melanogaster ]

    Gene ID: 43724, updated on 4-Feb-2012
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    Summary

    Official Symbol
    CycGprovided by Flybase
    Official Full Name
    Cyclin Gprovided by Flybase
    Primary source
    FLYBASE:FBgn0039858
    Locus tag
    Dmel_CG11525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.25; anon-EST:Liang-2.24; CG 11525; CG11525; clone 1.25; clone 2.24; dCycG; Dmel\CG11525; i205; i261
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    Genomic context

    Location :
    100C7-100C7
    Sequence :
    Chromosome: 3R; NT_033777.2 (27424172..27438386, complement)
    See CycG in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG1774 gene product from transcript CG1774-RA Neighboring gene Ribosomal protein L6 Neighboring gene Medea Neighboring gene CG11539 gene product from transcript CG11539-RA Neighboring gene CG1792 gene product from transcript CG1792-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. More about cyclin G from flies. Montagne J. Cell Cycle, 2011 Apr 15. PMID 21441780.
    2. Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation. Faradji F, et al. Cell Cycle, 2011 Mar 1. PMID 21311225.
    3. Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. Rach EA, et al. Genome Biol, 2009. PMID 19589141.
    4. Regulation of Abd-B expression by Cyclin G and Corto in the abdominal epithelium of Drosophila. Salvaing J, et al. Hereditas, 2008 Jun. PMID 18667003.
    5. The enhancer of trithorax and polycomb corto interacts with cyclin G in Drosophila. Salvaing J, et al. PLoS One, 2008 Feb 20. PMID 18286205.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Cyclin G is encoded by an essential gene, since either RNAi-disruption or cDNA overexpression resulted in high lethality.
      Title: More about cyclin G from flies.
    2. Overproduction of Cyclin G produces small cells whereas shortage produces large cells, suggesting that Cyclin G negatively regulates cell growth.
      Title: Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation.
    3. interaction between the Enhancer of Trithorax and Polycomb Corto and Cyclin G is involved in regulating the balance between cell proliferation and cell differentiation during abdominal epithelium development
      Title: Regulation of Abd-B expression by Cyclin G and Corto in the abdominal epithelium of Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:68567 BioGRID:64886 26-29-p    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68627 Asator    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58145 CBP    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62372 CG10139    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62397 CG10209    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66041 CG1104    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63867 CG11486    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58656 CG12723    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63211 CG13510    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:67857 CG13625    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63807 CG13806    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63648 CG13900    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:64811 CG14119    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59406 CG14619    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59148 CG15043    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58684 CG15753    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58330 CG16892    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62248 CG18278    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:72813 CG18745    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:76940 CG31204    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59632 CG31679    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:77327 CG31961    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:61742 CG34350    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63247 CG3499    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:64490 CG3552    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65556 CG4365    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68004 CG4673    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68229 CG4980    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68226 CG5003    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65080 CG5151    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:60452 CG5708    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63695 CG9184    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:60757 CG9426    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66023 Ccp84Aa    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66022 Ccp84Ab    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62567 Cdk4    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66526 Csk    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:61365 Cul-2    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66871 CycC    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:72482 CycK    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66030 Dfd    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:69651 E5    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:61444 EcR    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:61367 Ef2b    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58272 Lim1    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59479 MED15    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59745 Mad    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59275 Mer    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65194 Nc73EF    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63381 PHDP    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68318 Pglym78    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68008 RASSF8    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65211 Rbp6    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65893 RpL13A    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:78249 RpL5    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65629 SAK    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62820 SP2637    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:64904 Sox21b    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:60577 Stam    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:59992 Vm26Ab    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:67081 abd-A    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:66028 bcd    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:60495 cdc2    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:67428 cdc2c    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:60833 cenG1A    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:61832 dap    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58076 dx    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62866 ena    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:64513 fry    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:61396 gus    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:71508 heph    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:63343 l(2)efl    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:58878 mRpS30    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68607 pan    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:69325 plu    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:65883 rev7    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:62080 skpB    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68433 spn-A    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:57663 sta    BioGRID  PubMed Two-hybrid 
    NP_731924.1 stumps    BIND  PubMed Dof interacts with an unspecified isoform of CycG. 
    BioGRID:68567 BioGRID:64244 unc-13-4A    BioGRID  PubMed Two-hybrid 
    BioGRID:68567 BioGRID:68196 wdb    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the CycG gene: The CycG gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    cyclin-dependent protein kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    negative regulation of G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		  
    negative regulation of S phase of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		  
    Component Evidence Code Pubs
    polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG11525 gene product from transcript CG11525-RD
    Names
    CG11525-PA
    CG11525-PB
    CG11525-PC
    CG11525-PD
    CG11525-PE
    CycG-PA
    CycG-PB
    CycG-PC
    CycG-PD
    CycG-PE
    cyclin G
    cyclin G1
    NP_524609.2
    NP_733434.1
    NP_733435.1
    NP_733436.1
    NP_733437.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      27424172..27438386, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170557.1 → NP_733436.1  cyclin G, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TJ9
      Related
      FBpp0085160, FBtr0085799
      Conserved Domains (1) summary
      cl00050
      Location:287 – 365
      Blast Score: 117
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. NM_170558.1 → NP_733437.1  cyclin G, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMG7
      Related
      FBpp0085162, FBtr0085801
      Conserved Domains (1) summary
      cl00050
      Location:3 – 81
      Blast Score: 114
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    3. NM_079870.2 → NP_524609.2  cyclin G, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TJ9
      Related
      FBpp0085161, FBtr0085800
      Conserved Domains (1) summary
      cl00050
      Location:287 – 365
      Blast Score: 117
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    4. NM_170555.1 → NP_733434.1  cyclin G, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TJ9
      Related
      FBpp0085163, FBtr0085802
      Conserved Domains (1) summary
      cl00050
      Location:287 – 365
      Blast Score: 117
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    5. NM_170556.1 → NP_733435.1  cyclin G, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TJ9
      Related
      FBpp0085164, FBtr0085803
      Conserved Domains (1) summary
      cl00050
      Location:287 – 365
      Blast Score: 117
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY058720.1 AAL13949.1
    genomic AE014297.2 AAF57171.2
    genomic AE014297.2 AAF57169.2
    genomic AE014297.2 AAF57170.2
    genomic AE014297.2 AAF57168.2
    genomic AE014297.2 AAN14276.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q9V9W0.1 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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