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    ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [ Homo sapiens ]

    Gene ID: 4363, updated on 20-May-2012
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    Summary

    Official Symbol
    ABCC1provided by HGNC
    Official Full Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 1provided by HGNC
    Primary source
    HGNC:51
    See related
    Ensembl:ENSG00000103222; HPRD:01153; MIM:158343; Vega:OTTHUMG00000048267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRP; ABCC; GS-X; MRP1; ABC29; DKFZp781G125; DKFZp686N04233
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
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    Genomic context

    Location :
    16p13.1
    Sequence :
    Chromosome: 16; NC_000016.9 (16043434..16236931)
    See ABCC1 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene FGFR1OP N-terminal like Neighboring gene ribosomal protein L15 pseudogene 20 Neighboring gene ribosomal protein L17 pseudogene 40 Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Neighboring gene NODAL modulator 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria. Roundhill EA, et al. Br J Cancer, 2012 Mar 13. PMID 22353810.
    2. Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). Iram SH, et al. J Biol Chem, 2012 Mar 2. PMID 22232552.
    3. Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Cho S, et al. Proc Natl Acad Sci U S A, 2011 Dec 20. PMID 22143792.
    4. Lung resistance protein and multidrug resistance protein in non-small cell lung cancer and their clinical significance. Chen ZJ, et al. J Int Med Res, 2011. PMID 22117969.
    5. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. Lok HC, et al. J Biol Chem, 2012 Jan 2. PMID 22084240.

    See all (227) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. For the first time, we have identified MRP-1 with efflux activity in human mitochondria.
      Title: Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
    2. DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity
      Title: Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.
    3. MDR1, MRP1 and BCL-2 have potential clinical relevance in adult patients with acute leukemia in the context of induction chemotherapy.
      Title: Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy.
    4. the critical and complex role of CL5 for stable expression of MRP1 at the plasma membrane
      Title: Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1).
    5. orientation of transmembrane fragments 4 and 10 from hMRP1/ABCC1 in membrane mimics
      Title: Transverse and tangential orientation of predicted transmembrane fragments 4 and 10 from the human multidrug resistance protein (hMRP1/ABCC1) in membrane mimics.
    6. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were associated with lower LVFS (left ventricular fractional shortening) after chemotherapy.
      Title: ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia.
    7. LRP and MRP play a role in multidrug resistance in non-small cell lung cancer (NSCLC) and are related to prognosis in patients with NSCLC
      Title: Lung resistance protein and multidrug resistance protein in non-small cell lung cancer and their clinical significance.
    8. The Arg723Gln (2168G > A) polymorphism of ABCC1 appears to be a potential susceptibility marker for lung cancer in the Chinese population.
      Title: ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population.
    9. Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells
      Title: Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells.
    10. ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP expression correlated with pancreatic cancer tumorigenesis and drug resistance in a mechanism that is independent of promoter methylation
      Title: Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer.
    Submit: New GeneRIF Correction See all (170)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates expression of MRP1 through activation of the mitogen-activated protein kinase signaling cascade PubMed
    tat HIV-1 Tat specifically upregulates MRP1 messenger ribonucleic acid and protein expression both in brain microvascular endothelial cells (BMEC) and astrocytes PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:110503 BioGRID:130988 TMEM173    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110503 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110503 BioGRID:123557 UNC93B1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ABC transporters, organism-specific biosystem (from KEGG)
      ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC transporters, conserved biosystem (from KEGG)
      ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
      ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
    • Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
      Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
    • Leukotriene synthesis, organism-specific biosystem (from REACTOME)
      Leukotriene synthesis, organism-specific biosystemLeukotrienes are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attraction and...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Prostanoid metabolism, organism-specific biosystem (from REACTOME)
      Prostanoid metabolism, organism-specific biosystemProstanoid hormones are formed from the precursor arachidonic acid (AA) in the local environment. This happens in three stages;1. AA is mobilized from precursor lipids by lipases2. AA is converted to...
    • S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P1 pathway, organism-specific biosystem
      S1P1 pathway
    • Sphingosine 1-phosphate (S1P) pathway, organism-specific biosystem (from Pathway Interaction Database)
      Sphingosine 1-phosphate (S1P) pathway, organism-specific biosystem
      Sphingosine 1-phosphate (S1P) pathway
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
      Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    • Vitamin digestion and absorption, conserved biosystem (from KEGG)
      Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ATP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    leukotriene biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    prostanoid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    response to drug TAS
    Traceable Author Statement
    more info
    		 PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    multidrug resistance-associated protein 1
    Names
    multidrug resistance-associated protein 1
    LTC4 transporter
    leukotriene C(4) transporter
    ATP-binding cassette transporter variant ABCC1delta-ex13
    ATP-binding cassette transporter variant ABCC1delta-ex25
    ATP-binding cassette transporter variant ABCC1delta-ex13&14
    ATP-binding cassette transporter variant ABCC1delta-ex25&26
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028268.1 RefSeqGene

      Range
      5001..198498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004996.3 → NP_004987.2  multidrug resistance-associated protein 1

      Status: REVIEWED

      Source sequence(s)
      AC025778, AC130651, AC136624, X78338
      Consensus CDS
      CCDS42122.1
      UniProtKB/Swiss-Prot
      P33527
      Related
      ENSP00000382342, OTTHUMP00000045904, ENST00000399410, OTTHUMT00000109701
      Conserved Domains (4) summary
      cd03244
      Location:1291 – 1511
      Blast Score: 894
      ABCC_MRP_domain2; Domain 2 of the ABC subfamily C. This family is also known as MRP (mulrtidrug resisitance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional ...
      cd03250
      Location:644 – 845
      Blast Score: 835
      ABCC_MRP_domain1; Domain 1 of the ABC subfamily C. This family is also known as MRP (mulrtidrug resisitance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminas, but the function of these additional ...
      TIGR00957
      Location:7 – 1530
      Blast Score: 7449
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cl00549
      Location:325 – 596
      Blast Score: 390
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      16043434..16236931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      15436705..15630893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019862.2: Suppressed sequence

      Description
      NM_019862.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.

    2. NM_019898.2: Suppressed sequence

      Description
      NM_019898.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.

    3. NM_019899.2: Suppressed sequence

      Description
      NM_019899.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.

    4. NM_019900.2: Suppressed sequence

      Description
      NM_019900.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.

    5. NM_019901.1: Suppressed sequence

      Description
      NM_019901.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

    6. NM_019902.1: Suppressed sequence

      Description
      NM_019902.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC003026.1 AAC05808.1
    genomic AC025778.8 (97100..205747) None
    genomic AC130651.2 (116854..152437) None
    genomic AC136624.3 (160181..209447) None
    genomic AF022853.1 AAB83979.1
      AAB83980.1
      AAB83981.1
      AAB83982.1
      AAB83983.1
    genomic CH471226.1 EAW53936.1
      EAW53937.1
      EAW53938.1
      EAW53939.1
      EAW53940.1
      EAW53941.1
      EAW53942.1
      EAW53943.1
      EAW53944.1
      EAW53945.1
      EAW53946.1
      EAW53947.1
      EAW53948.1
      EAW53949.1
    genomic EF419769.1 ABN79590.1
    genomic U91318.1 AAC15784.1
    mRNA AB209120.1 BAD92357.1
    mRNA AJ003198.1 None
    mRNA AK311015.1 None
    mRNA BC001636.1 AAH01636.1
    mRNA BX648866.1 None
    mRNA CR749835.1 CAH18691.1
    mRNA HQ917064.1 AEK86268.1
    mRNA HQ917065.1 AEK86269.1
    mRNA HQ917066.1 AEK86270.1
    mRNA HQ917067.1 AEK86271.1
    mRNA L05628.1 AAB46616.1
    mRNA X78338.1 None
    other-genetic BC156353.1 AAI56354.1
    other-genetic BC157105.1 AAI57106.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33527.3 GenPept UniProtKB/Swiss-Prot:P33527
    Q68CP7 GenPept UniProtKB/TrEMBL:Q68CP7
    Q9BV39 GenPept UniProtKB/TrEMBL:Q9BV39
    Q9UQ98 GenPept UniProtKB/TrEMBL:Q9UQ98
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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